日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Chiglitazar in MASLD with hypertriglyceridemia and insulin resistance: A phase II, randomized, double-blind, placebo-controlled study

奇格列他扎治疗伴有高甘油三酯血症和胰岛素抵抗的MASLD：一项II期随机、双盲、安慰剂对照研究

期刊:Hepatology
影响因子:15.8
doi:10.1097/HEP.0000000000001475
Sun, Yameng; Wu, Cuisong; Xin, Guijie; Zhong, Bihui; Wu, Xiaofeng; Liu, Yali; Shi, Junping; Zhang, Qin; Zhao, Yingren; Gao, Yufeng; Xin, Yongning; Zhu, Yueyong; Wu, Lixian; Mao, Xiaorong; Du, Jian; Shang, Jia; Sun, Weiwei; Xu, Jie; Yu, Zujiang; Nan, Yuemin; Sheng, Huiping; Li, Yue; Rao, Huiying; Yu, Chaohui; Cao, Haixiang; Chen, Bo; Li, Zhibin; Wu, Xiaoning; Tong, Xiaofei; You, Hong
代谢
免疫/内分泌
发表日期：2026
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Glutaredoxin 1 promotes intestinal epithelial cell copper toxicity in inflammatory bowel disease

谷胱甘肽还原酶1促进炎症性肠病中肠上皮细胞的铜毒性

期刊:Redox Biology
影响因子:11.9
doi:10.1016/j.redox.2026.104164
Zhang, Tiantian; Zhang, Xiaofen; Cai, Huimei; Yu, Mengli; Liu, Qichen; Song, Xin; Lin, Bingru; Xu, Linjie; Li, Lan; Shen, Zhe; Yu, Chaohui; Zhang, Jie
炎症
炎症/感染
上皮细胞
细胞生物学
毒理研究
发表日期：2026
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NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress

二十二碳六烯酸上调NRF1，通过抑制内质网应激来改善MASH。

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-08139-1
Lin, Mengchi; Zhang, Hongtao; Chen, Shuai; Zhang, Jie; Tang, Chenxi; Song, Xin; Zhou, Jiaming; Xu, Zixin; Mu, Yali; Zeng, Hang; Yang, Changqing; Yu, Chaohui; Xu, Chengfu
内质网应激
发表日期：2026
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A new inject-embed 3D culture method enables the spheroid and aggregate formation from single or dual liver cancer cell types.

一种新的注射-包埋 3D 培养方法能够从单一或两种肝癌细胞类型中形成球状体和聚集体。

期刊:Cancer Cell International
影响因子:6
doi:10.1186/s12935-026-04250-1
Zhang Hanyuan, Xue Shuting, Pan Jinchang, Zhang Jianjuan, Wei Danduo, Xia Peng, Li Guangming, Roessler Stephanie, Yu Chaohui, Ji Junfang
肿瘤
肿瘤免疫
肝癌
3D/类器官
细胞生物学
发表日期：2026
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Aspartate treatment ameliorates metabolic dysfunction-associated fatty liver disease through upregulation of CBS and suppression of ferroptosis

天冬氨酸治疗可通过上调CBS和抑制铁死亡来改善代谢功能障碍相关的脂肪肝疾病。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2026.111318
Zhang, Jie; Lin, Shihua; Zhang, Tiantian; Son, Xing; Yu, Chaohui
CBS
脂肪肝
铁死亡
代谢
发表日期：2026
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Integrated Metabolic and Inflammatory Clustering Reveals Distinct Risk Profiles for Digestive Diseases

代谢和炎症综合聚类分析揭示消化系统疾病的不同风险特征

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202511000
Jin, Zhenhe; Chen, Qichen; Zhou, Liangfeng; Ye, Kexin; Liu, Zhaoxue; Jiang, Wenxi; Luo, Linwen; Wang, Yize; Ye, Xiaohua; Yu, Chaohui; Shen, Zhe
炎症/感染
炎症
代谢
发表日期：2025
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Bone marrow-derived CD169(+) macrophages promote autoimmune hepatitis by recruiting CCR2(+) monocytes via secreting CCL12

骨髓来源的CD169(+)巨噬细胞通过分泌CCL12募集CCR2(+)单核细胞，从而促进自身免疫性肝炎。

期刊:Experimental and Molecular Medicine
影响因子:12.9
doi:10.1038/s12276-025-01607-w
Lin, Bingru; Zhang, Huayang; Zhu, Pengwei; Chen, Jianing; Li, Dingwu; Zhou, Jiaming; Zhang, Tiantian; Chen, Qingxia; Tang, Chenxi; Song, Xin; Zeng, Hang; Wang, Jinghua; Zhang, Jie; You, Zhengrui; Ma, Xiong; Yu, Chaohui
巨噬细胞
CR2
CD16
巨噬细胞
CCL1
CCL12
单核细胞
自身免疫性肝炎
细胞生物学
肝炎
免疫/内分泌
发表日期：2025
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Endoscopic ultrasound-guided endoscopic submucosal dissection to remove a fishbone embedded adjacent to the thoracic aorta

内镜超声引导下内镜黏膜下剥离术取出嵌顿于胸主动脉旁的鱼刺

期刊:Endoscopy
影响因子:12.8
doi:10.1055/a-2667-7534
Xiong, Yangyang; Yu, Mosang; Yu, Chaohui; Shen, Zhe
发表日期：2025
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The deubiquitinase USP28 maintains the expression of PPARγ and its inactivation protects mice from diet-induced MASH and hepatocarcinoma

去泛素化酶USP28维持PPARγ的表达，其失活可保护小鼠免受饮食诱导的MASH和肝癌的侵害。

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2025.01.046
Cai, Changzhou; Luo, Hangqi; Peng, Jin; Zhen, Xinghua; Shen, Xiang; Xi, Xiaomei; Zhu, Jianrong; Fang, Yanfei; Chen, Xiaoli; Wang, Jiewei; Yu, Chaohui; Zhang, Pumin; Xu, Chengfu
肿瘤
表观遗传
肿瘤免疫
泛素化
肝癌
USP28
发表日期：2025
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DJ-1 counteracts Caveolin-1-mediated necroptosis to inhibit epithelial barrier dysfunction in colitis

DJ-1通过拮抗Caveolin-1介导的坏死性凋亡来抑制结肠炎中的上皮屏障功能障碍。

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-07989-z
Yu, Mengli; Zhang, Jie; Lin, Bingru; Zhu, Wei; Song, Xin; Pan, Jiaqi; Li, Dingwu; He, Xinjue; Sun, Jing; Shen, Zhe; Yu, Chaohui
凋亡
肠炎
表观遗传
Caveolin-1
结肠炎
DJ-1
发表日期：2025
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