27-Hydroxycholesterol triggers microglial senescence subsequent to iron over-loading contributes to brain aging, suppressed by Deferoxamine.
27-羟基胆固醇会引发小胶质细胞衰老,继而导致铁过载,从而加速大脑衰老,而去铁胺可以抑制这一过程。
期刊:NPJ Aging
影响因子:6
doi:10.1038/s41514-025-00303-3
Yu Chunyang, Wang Wencheng, Shi Lei, Ma Rui, Zhang Yawen, Zhang Chun, Wang Xuewei, Wang Tianqi, Zheng Yan, Tian Jianying
衰老
细胞生物学
胶质细胞
Senescence
细胞衰老