日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

EZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of m6A autoregulation pathway.

EZH2 与 RNA 甲基化的相互作用通过调节 m6A 自调节通路促进前列腺癌的进展。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI195840
Yi Yang, Fry Joshua, Yum Chaehyun, Wang Rui, Wu Siqi, Narayan Sharath, Liu Qi, Zhang Xingxing, Oo Htoo Zarni, Xie Ning, Li Yanqiang, Gao Xinlei, Yu Xufen, Hu Xiaoping, Li Qiaqia, Keseroglu Kemal, Özbudak Ertuğrul M, Abdulkadir Sarki A, Chen Kaifu, Jin Jian, Zhao Jonathan C, Dong Xuesen, Arango Daniel, Yang Rendong, Cao Qi
m6A/m5C/m7G
肿瘤
表观遗传
肿瘤免疫
信号转导
EZH2
前列腺癌
发表日期：2026
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Tumor microenvironment-targeted PROTAC nanoparticle self-assembly broadly predicted by structural descriptors.

肿瘤微环境靶向 PROTAC 纳米颗粒自组装可通过结构描述符进行广泛预测。

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.adu2292
Vogt Kristen C, Panagiotakopoulou Magdalini, Manzari Honu Mandana T, Perea Ana Marie, Hu Xiaoping, Yu Xufen, Raziuddin Raashed, LaPlant Quincey, Ruiz Stephen, Raju G Praveen, Jin Jian, Scheinberg David A, Heller Daniel A
肿瘤
肿瘤微环境
发表日期：2025
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Pharmacologic degradation of WDR5 suppresses oncogenic activities of SS18::SSX and provides a therapeutic of synovial sarcoma.

WDR5 的药理降解可抑制 SS18::SSX 的致癌活性，并为滑膜肉瘤的治疗提供可能

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.ads7876
Yu Yao, Yu Xufen, Pan Bo, Chan Ho Man, Kaniskan H Ümit, Jin Jian, Cai Ling, Wang Gang Greg
肿瘤
肿瘤免疫
发表日期：2025
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Ketone drink enhances therapeutic efficacy in prostate cancer by targeting EZH2

酮类饮料通过靶向 EZH2 增强前列腺癌的治疗效果

期刊:Oncogenesis
影响因子:6.4
doi:10.1038/s41389-025-00567-0
Yum, Chaehyun; Schaefer, Richard A; Wang, Rui; Wang, Ting-You; Lu, Xiaotong; Liu, Qi; Ren, Yanan; Meng, Qingshu; Yang, Yongyong; Zhang, Xin; Xiong, Yan; Yu, Xufen; Zhang, Xiaoyu; Jin, Jian; Dong, Xuesen; Yi, Yang; Yang, Rendong; Cao, Qi
肿瘤
前列腺癌
肿瘤免疫
EZH2
发表日期：2025
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A First-in-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of Tumor Protein P53 Gene Activation in Preclinical Models of Gastric Cancer

一种首创的化学诱导邻近系统在胃癌临床前模型中实现了对肿瘤蛋白P53基因激活的剂量依赖性控制

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.5c00402
Nelson, Travis J; Kemper, Ryan M; Chiarella, Anna M; Gonzalez Tineo, Stephany; Carroll, Michell; Tripathi, Surya; Clarke, Brandon J; Yu, Xufen; Hu, Xiaoping; Cooke, Aidan J; Chirumamilla, Bhavika C; Chandler, Alicia; McGilvary, Evan; Pattenden, Samantha G; Jin, Jian; Crona, Daniel J; Hathaway, Nathaniel A
胃癌
肿瘤
肿瘤免疫
P53
发表日期：2025
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USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK.

基于 USP7 的去泛素化酶靶向嵌合体可稳定 AMPK

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.4c02373
Liu Jing, Hu Xiaoping, Luo Kaixiu, Xiong Yan, Chen Li, Wang Zhen, Inuzuka Hiroyuki, Qian Chao, Yu Xufen, Xie Ling, Muneer Adil, Zhang Dingpeng, Paulo Joao A, Chen Xian, Jin Jian, Wei Wenyi
表观遗传
AMPK
泛素化
发表日期：2024
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Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic

发现一种双重WDR5和Ikaros PROTAC降解剂作为抗癌疗法

期刊:Oncogene
影响因子:7.3
doi:10.1038/s41388-022-02340-8
Li, Dongxu; Yu, Xufen; Kottur, Jithesh; Gong, Weida; Zhang, Zhao; Storey, Aaron J; Tsai, Yi-Hsuan; Uryu, Hidetaka; Shen, Yudao; Byrum, Stephanie D; Edmondson, Rick D; Mackintosh, Samuel G; Cai, Ling; Liu, Zhijie; Aggarwal, Aneel K; Tackett, Alan J; Liu, Jing; Jin, Jian; Wang, Gang Greg
WDR5
肿瘤
Ikaros
肿瘤免疫
发表日期：2022
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A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models

一种选择性WDR5降解剂可抑制患者来源小鼠模型中的急性髓系白血病。

期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.abj1578
Yu, Xufen; Li, Dongxu; Kottur, Jithesh; Shen, Yudao; Kim, Huen Suk; Park, Kwang-Su; Tsai, Yi-Hsuan; Gong, Weida; Wang, Jun; Suzuki, Kyogo; Parker, Joel; Herring, Laura; Kaniskan, H Ümit; Cai, Ling; Jain, Rinku; Liu, Jing; Aggarwal, Aneel K; Wang, Gang Greg; Jin, Jian
白血病
WDR5
发表日期：2021
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Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68)

基于 Ogerin 的 G 蛋白偶联受体 68 (GPR68) 正向变构调节剂的设计、合成和表征

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.9b00869
Yu, Xufen; Huang, Xi-Ping; Kenakin, Terry P; Slocum, Samuel T; Chen, Xin; Martini, Michael L; Liu, Jing; Jin, Jian
信号转导
发表日期：2019
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miR-125a-5p inhibits the expression of NLRP3 by targeting CCL4 in human vascular smooth muscle cells treated with ox-LDL

miR-125a-5p 通过靶向 CCL4 抑制 ox-LDL 治疗的人血管平滑肌细胞中 NLRP3 的表达

期刊:Experimental and Therapeutic Medicine
影响因子:2.4
doi:10.3892/etm.2019.7717
Jiawang Wang, Qiong Wu, Jing Yu, Xufen Cao, Zesheng Xu
细胞生物学
其它细胞
WB
Human
G3P
发表日期：2019
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