Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO-1 Signaling Pathway in db/db Mice
运动和二甲双胍干预可通过减轻氧化应激和内质网应激并激活 db/db 小鼠的 AMPK/Nrf2/HO-1 信号通路来预防脂毒性诱导的肝细胞凋亡
期刊:Oxidative Medicine and Cellular Longevity
影响因子:
doi:10.1155/2022/2297268
Zhang, Yuan; Liu, Yuting; Liu, Xiaowei; Yuan, Xinmeng; Xiang, Mengqi; Liu, Jingjing; Zhang, Liumei; Zhu, Shouqian; Lu, Jiao; Tang, Qiang; Cheng, Sulin
凋亡
表观遗传
氧化应激
Apoptosis
信号转导
AMPK
内质网应激
细胞生物学
毒理研究
