Yue Lin相关文献与解析，生知库 | 链接生命科学的每一步

Chen, Xuanhan; Zhang, Mingkui; Cao, Lu; Fan, Dinggang; Wang, Long; Chen, Yue; Lin, Hao; Sun, Mingyuan; Tong, Shiyuan; Deng, Yuguo; Xiao, Bing; Li, Weihua; Hu, Bing; Zhang, Shiwu; Tang, Shi-Yang; Sun, Lining; Li, Xiangpeng

发表日期：2026

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TRIM24-mediated K27-linked ubiquitination of ULK1 alleviates energy stress-induced autophagy and promote prostate cancer growth in the context of SPOP mutation

TRIM24介导的ULK1 K27连接的泛素化可减轻能量应激诱导的自噬，并在SPOP突变的情况下促进前列腺癌的生长。

期刊:Cell Death and Differentiation

影响因子:15.4

doi:10.1038/s41418-025-01582-9

Chen, Shimin; Lin, Jichun; Yang, Zhan; Wang, Yuanjing; Wang, Qiang; Wang, Dong; Qu, Yue; Lin, Qian; Liu, Jia; Yan, Shi; Wang, Zixin; Qian, Xueyu; Xiao, Yutian; Li, Xue; Chen, Yinuo; Fang, Wenshuo; Zhao, Jiaojiao; Lu, Zhimin; Ren, He; Zhu, Yasheng; Ma, Leina

Coiled-coil heterodimer-mediated split base editing systems enable flexible and robust nucleotide substitutions

卷曲螺旋异二聚体介导的分裂碱基编辑系统能够实现灵活而稳健的核苷酸替换

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-026-68469-2.

Shuangshuang Mu #,Qianru Li #,Menglong Chen #,Ziqi Li,Yuke Ma,Yuqi Li,Yiran Song,Shuangying Hou,Yuting Ding,Jialu Ju,Yue Lin,Jian Zhang,Yuanxi Yang,Xue Ren,Nan Li,Qin Jin,Liangxue Lai,Kepin Wang,Hui Shi

碱基编辑

发表日期：2026

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An innovative and stable mRNA-LNP microneedle vaccine elicits humoral and multifunctional cellular immune responses.

一种创新且稳定的mRNA-LNP微针疫苗可引发体液免疫和多功能细胞免疫反应。

期刊:Acta Pharmaceutica Sinica B

影响因子:14.6

doi:10.1016/j.apsb.2025.10.006

Hong Xiaoxuan, Li Xianfu, Han Xiaolu, Lou Jinghu, Li Yue, Lin Jintao, Cheng Yi, Xing Haonan, Zhang Hui, Wang Xiwei, Zhang Shuang, Liu Nan, Wang Zengming, Cui Chunying, Zheng Aiping

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4-VCAM1 Signaling

内皮细胞中 Rap2a 的失活通过 MAP4K4-VCAM1 信号通路调节免疫微环境，从而预防肺纤维化

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202519892

Zheng, Xiaolan; Yue, Peng; Zhou, Kaiyu; Gong, Guidong; Zhang, Yue; Lin, Sha; Liu, Xu; Zheng, Yanjiang; Jing, Siyuan; Guo, Junling; Qi, Yan; Ding, Bi-Sen; Hua, Yimin; Li, Yifei

Archeological data with AI- and physics-based modeling explain typhoon-induced disasters in inland China around 3000 yr B.P

结合人工智能和物理建模的考古数据解释了距今约3000年前中国内陆地区台风引发的灾害。

期刊:Science Advances

影响因子:12.5

doi:10.1126/sciadv.aeb1598

Ding, Ke; Li, Siyang; Ding, Aijun; Lu, Houyuan; Zhang, Jianping; Xi, Dazhi; Huang, Xin; Lou, Sijia; Tang, Xiaodong; Qiu, Xin; He, Lejun; Ma, Yue; Lin, Haoxian; Zhang, Shiyan; Zhou, Derong; Zhou, Xiaolu; Tan, Zhe-Min; Fu, Congbin; Ge, Quansheng

发表日期：2026

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Epithelial plasticity shapes intratumoral heterogeneity and cell lineages in early-stage lung cancer.

上皮可塑性塑造早期肺癌的肿瘤内异质性和细胞谱系。

期刊:Science Advances

影响因子:12.5

doi:10.1126/sciadv.ady8546

Xiong Yangjie, Wang Xiaofang, Yan Kai, Xin Ning, Li Weiqing, Zhang Zhengwei, Cheng Yumei, Zeng Chunling, Luo Yuxiang, Liu Xiaoxiao, Lu Xiaojing, Yan Xinhui, Lan Haoqi, Wu Tanwen, Dong Yue, Lin Xu, Li Ying, Jia Xiaona, Wang Simin, Tang Hua, Wang Yuexiang

Dual-functional hydrogel platform suppresses M1 activation and stabilizes M2 macrophages in intervertebral disc degeneration

双功能水凝胶平台抑制椎间盘退变中M1型巨噬细胞活化并稳定M2型巨噬细胞。

期刊:Materials Today Bio

影响因子:10.2

doi:10.1016/j.mtbio.2026.103087

Xu, Yiwen; Zhang, Zijun; Chen, Zhenzhong; Xi, Miao; Liu, Hong; Wang, Kelei; Xue, Yucheng; Li, Zilong; Fang, Miaojie; Lin, Yue; Lin, Feng; Zhang, Ning

Organoid models: Regulations and prospects for the development of investigational new drugs

类器官模型：新药研发的监管与前景

期刊:Chinese Medical Journal

影响因子:7.3

doi:10.1097/CM9.0000000000004067

Li, Huachao; Pan, Yin; Zheng, Zhibao; Lin, Renzhi; Pan, Yue; Lin, Lizhong; Quan, Mingming; Lu, Hongsheng; Hu, Zhe; Zheng, Mingbin; Chen, Yihua; Zhang, Yuzhu

3D/类器官

发表日期：2026

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Cancer-derived fucosylated exosomal miR-6842-3p as a novel marker promotes ESCC angiogenesis and metastasis via the PTEN/AKT/mTOR/IRF1/CXCL10 axis

癌细胞来源的岩藻糖基化外泌体 miR-6842-3p 作为一种新型标志物，通过 PTEN/AKT/mTOR/IRF1/CXCL10 轴促进食管鳞状细胞癌的血管生成和转移。

期刊:Oncogene

影响因子:7.3

doi:10.1038/s41388-025-03643-2

Chen, Jianlin; Chen, Jing; Lv, Xiang; Chen, Xiongfeng; Ming, Liu; Huang, Xinghua; Wen, Fuli; Tang, Haijun; Gao, Qi; Liu, Chengxiu; Weng, Jiamiao; Huang, Zhixin; Zheng, Yue; Lin, Fan; Chen, Wenshu; Shang, Xiuling; Yu, Chundong; Huang, Yi

Liquid metal universal grippers for gentle, adaptable, multiscale manipulation

用于轻柔、灵活、多尺度操作的液态金属通用夹具

TRIM24-mediated K27-linked ubiquitination of ULK1 alleviates energy stress-induced autophagy and promote prostate cancer growth in the context of SPOP mutation

TRIM24介导的ULK1 K27连接的泛素化可减轻能量应激诱导的自噬，并在SPOP突变的情况下促进前列腺癌的生长。

Coiled-coil heterodimer-mediated split base editing systems enable flexible and robust nucleotide substitutions

卷曲螺旋异二聚体介导的分裂碱基编辑系统能够实现灵活而稳健的核苷酸替换

An innovative and stable mRNA-LNP microneedle vaccine elicits humoral and multifunctional cellular immune responses.

一种创新且稳定的mRNA-LNP微针疫苗可引发体液免疫和多功能细胞免疫反应。

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4-VCAM1 Signaling

内皮细胞中 Rap2a 的失活通过 MAP4K4-VCAM1 信号通路调节免疫微环境，从而预防肺纤维化

Archeological data with AI- and physics-based modeling explain typhoon-induced disasters in inland China around 3000 yr B.P

结合人工智能和物理建模的考古数据解释了距今约3000年前中国内陆地区台风引发的灾害。

Epithelial plasticity shapes intratumoral heterogeneity and cell lineages in early-stage lung cancer.

上皮可塑性塑造早期肺癌的肿瘤内异质性和细胞谱系。

Dual-functional hydrogel platform suppresses M1 activation and stabilizes M2 macrophages in intervertebral disc degeneration

双功能水凝胶平台抑制椎间盘退变中M1型巨噬细胞活化并稳定M2型巨噬细胞。

Organoid models: Regulations and prospects for the development of investigational new drugs

类器官模型：新药研发的监管与前景

Cancer-derived fucosylated exosomal miR-6842-3p as a novel marker promotes ESCC angiogenesis and metastasis via the PTEN/AKT/mTOR/IRF1/CXCL10 axis

癌细胞来源的岩藻糖基化外泌体 miR-6842-3p 作为一种新型标志物，通过 PTEN/AKT/mTOR/IRF1/CXCL10 轴促进食管鳞状细胞癌的血管生成和转移。