日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

HDAC6 Inhibition Reduces Seeded Tau and α-Synuclein Pathologies in Primary Neuron Cultures and Wild-Type Mice

HDAC6抑制剂可减少原代神经元培养物和野生型小鼠中播散的tau蛋白和α-突触核蛋白病理

期刊:Journal of Neuroscience
影响因子:4
doi:10.1523/JNEUROSCI.1092-25.2025
Crowe, Alex; Yao, Yuemang; Newman, Mira; Hoxha, Kevt'her; Baffic, Thallyah; Brunden, Kurt R
HDAC6
神经科学
发表日期：2026
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A small-molecule microtubule-stabilizing agent safely reduces Aβ plaque and tau pathology in transgenic mouse models of Alzheimer's disease

小分子微管稳定剂可安全地减少阿尔茨海默病转基因小鼠模型中的 Aβ 斑块和 tau 病理

期刊:Alzheimers & Dementia
影响因子:13
doi:10.1002/alz.13875
Yuemang Yao, Megan Muench, Thibault Alle, Bin Zhang, Bobby Lucero, Roxanne Perez-Tremble, Dominic McGrosso, Mira Newman, David J Gonzalez, Virginia M-Y Lee, Carlo Ballatore, Kurt R Brunden
神经
阿尔茨海默症
Mouse
发表日期：2024
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Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies.

设计、合成和评价抗锥虫[1,2,4]三唑并[1,5-a]嘧啶探针用于光亲和标记研究

期刊:ChemMedChem
影响因子:3.4
doi:10.1002/cmdc.202300656
Lucero Bobby, Francisco Karol R, Varricchio Carmine, Liu Lawrence J, Yao Yuemang, Brancale Andrea, Brunden Kurt R, Caffrey Conor R, Ballatore Carlo
发表日期：2024
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Microtubule-Stabilizing 1,2,4-Triazolo[1,5- a]pyrimidines as Candidate Therapeutics for Neurodegenerative Disease: Matched Molecular Pair Analyses and Computational Studies Reveal New Structure-Activity Insights

微管稳定 1,2,4-三唑并[1,5- a]嘧啶作为神经退行性疾病的候选治疗药物：匹配分子对分析和计算研究揭示新的结构-活性见解

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.2c01411
Thibault Alle, Carmine Varricchio, Yuemang Yao, Bobby Lucero, Goodwell Nzou, Stefania Demuro, Megan Muench, Khoa D Vuong, Killian Oukoloff, Anne-Sophie Cornec, Karol R Francisco, Conor R Caffrey, Virginia M-Y Lee, Amos B Smith 3rd, Andrea Brancale, Kurt R Brunden, Carlo Ballatore
神经
发表日期：2023
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A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

脑渗透性三唑并嘧啶可增强微管稳定性、减少轴突功能障碍并降低小鼠 tau 蛋白病模型中的 tau 病理

期刊:Molecular Neurodegeneration
影响因子:14.9
doi:10.1186/s13024-018-0291-3
Bin Zhang, Yuemang Yao, Anne-Sophie Cornec, Killian Oukoloff, Michael J James, Pyry Koivula, John Q Trojanowski, Amos B Smith 3rd, Virginia M-Y Lee, Carlo Ballatore, Kurt R Brunden
神经科学
发表日期：2018
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Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines

微管（MT）活性[1,2,4]三唑并[1,5-a]嘧啶的光活化衍生物的设计、合成和评价

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2018.05.010
Oukoloff, Killian; Kovalevich, Jane; Cornec, Anne-Sophie; Yao, Yuemang; Owyang, Zachary A; James, Michael; Trojanowski, John Q; Lee, Virginia M-Y; Smith, Amos B 3rd; Brunden, Kurt R; Ballatore, Carlo
发表日期：2018
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Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases

多靶点咪唑：阿尔茨海默病和其他神经退行性疾病的潜在治疗线索

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.7b00475
Anne-Sophie Cornec, Ludovica Monti, Jane Kovalevich, Vishruti Makani, Michael J James, Krishna G Vijayendran, Killian Oukoloff, Yuemang Yao, Virginia M-Y Lee, John Q Trojanowski, Amos B Smith 3rd, Kurt R Brunden, Carlo Ballatore
神经
发表日期：2017
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Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group

对氧杂环丁烷-3-醇、噻丁烷-3-醇及其衍生物作为羧酸官能团生物等排体的评价

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.7b00212
Lassalas, Pierrik; Oukoloff, Killian; Makani, Vishruti; James, Michael; Tran, Van; Yao, Yuemang; Huang, Longchuan; Vijayendran, Krishna; Monti, Ludovica; Trojanowski, John Q; Lee, Virginia M-Y; Kozlowski, Marisa C; Smith, Amos B 3rd; Brunden, Kurt R; Ballatore, Carlo
发表日期：2017
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Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy

在PS19 tau转基因小鼠tau蛋白病模型中评估脑穿透性微管稳定剂dictyostatin的作用

期刊:Acta Neuropathologica Communications
影响因子:5.7
doi:10.1186/s40478-016-0378-4
Makani, Vishruti; Zhang, Bin; Han, Heeoon; Yao, Yuemang; Lassalas, Pierrik; Lou, Kevin; Paterson, Ian; Lee, Virginia M Y; Trojanowski, John Q; Ballatore, Carlo; Smith, Amos B 3rd; Brunden, Kurt R
神经科学
发表日期：2016
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Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors

炎性二十烷酸通过激活多种神经元受体增加淀粉样蛋白前体的表达

期刊:Scientific Reports
影响因子:3.8
doi:10.1038/srep18286
Katie J Herbst-Robinson, Li Liu, Michael James, Yuemang Yao, Sharon X Xie, Kurt R Brunden
神经
发表日期：2015
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