Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC
严重急性呼吸综合征冠状病毒ORF3a蛋白通过促进TRAF3依赖的ASC泛素化来激活NLRP3炎症小体。
期刊:FASEB Journal
影响因子:4.2
doi:10.1096/fj.201802418R
Siu, Kam-Leung; Yuen, Kit-San; Castaño-Rodriguez, Carlos; Ye, Zi-Wei; Yeung, Man-Lung; Fung, Sin-Yee; Yuan, Shuofeng; Chan, Chi-Ping; Yuen, Kwok-Yung; Enjuanes, Luis; Jin, Dong-Yan
炎症
表观遗传
炎性小体
炎症/感染
泛素化
TRAF3
ASC
微生物学
LRP3
NLRP3
炎性小体
免疫/内分泌