MED12 mutation induces RTK inhibitor resistance in NSCLC via MEK/ERK pathway activation by inflammatory cytokines.
MED12 突变通过炎症细胞因子激活 MEK/ERK 通路,诱导 NSCLC 对 RTK 抑制剂产生耐药性
期刊:Cellular and Molecular Life Sciences
影响因子:6.2
doi:10.1007/s00018-025-05791-w
Ryu Hyun-Min, Kim Deokhoon, Choi Jun Young, Yoon Shinkyo, Lee Ho-Su, Park Ji Eun, Lee Eunjin, Sung Yunkyung, Lee Chang Hoon, Lee Eun-Young, Kim Wanlim, Seo Seyoung, Kim Sang-We, Park Kang-Seo, Lee Dae Ho