日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration

SerpinE2 对丝氨酸蛋白酶 HtrA1 的抑制表明,存在一条控制神经嵴迁移的细胞外蛋白水解途径

Edgar M Pera, Josefine Nilsson-De Moura, Yuriy Pomeshchik, Laurent Roybon, Ivana Milas

Generation of an induced pluripotent stem cell line (CSC-32) from a patient with Parkinson's disease carrying a heterozygous variation p.A53T in the SNCA gene

从携带 SNCA 基因杂合变异 p.A53T 的帕金森病患者体内生成诱导性多能干细胞系 (CSC-32)

Carla Azevedo, Margarita Chumarina, Evgenija Serafimova, Stefano Goldwurm, Anna Collin, Laurent Roybon, Ekaterina Savchenko, Yuriy Pomeshchik

Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer's disease pathogenesis

对基于患者 iPSC 的模型和人类死后海马组织进行蛋白质组学分析,揭示了早期细胞功能障碍和阿尔茨海默病发病机制的进展

Yuriy Pomeshchik, Erika Velasquez, Jeovanis Gil, Oxana Klementieva, Ritha Gidlöf, Marie Sydoff, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Gunilla Westergren-Thorsson, Gunnar K Gouras, Melinda Rezeli, Laurent Roybon8

Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties

帕金森病和多系统萎缩症患者 iPSC 衍生的少突胶质细胞表现出 α-突触核蛋白诱导的成熟和免疫反应特性变化

Carla Azevedo, Gabriel Teku, Yuriy Pomeshchik, Juan F Reyes, Margarita Chumarina, Kaspar Russ, Ekaterina Savchenko, Anna Hammarberg, Nuno Jorge Lamas, Anna Collin, Gunnar K Gouras, Oxana Klementieva, Martin Hallbeck, Ricardo Taipa, Mauno Vihinen, Laurent Roybon

TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

TNF-α 和 α-突触核蛋白原纤维以不同的方式调节人类星形胶质细胞的免疫反应并损害线粒体呼吸

Kaspar Russ, Gabriel Teku, Luc Bousset, Virginie Redeker, Sara Piel, Ekaterina Savchenko, Yuriy Pomeshchik, Jimmy Savistchenko, Tina C Stummann, Carla Azevedo, Anna Collin, Stefano Goldwurm, Karina Fog, Eskil Elmer, Mauno Vihinen, Ronald Melki, Laurent Roybon

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

芳基噻嗪衍生物是脂质过氧化和铁死亡的有效抑制剂,可在体外和体内提供神经保护

Meike Hedwig Keuters, Velta Keksa-Goldsteine, Hiramani Dhungana, Mikko T Huuskonen, Yuriy Pomeshchik, Ekaterina Savchenko, Paula K Korhonen, Yajuvinder Singh, Sara Wojciechowski, Šárka Lehtonen, Katja M Kanninen, Tarja Malm, Jouni Sirviö, Anu Muona, Milla Koistinaho, Gundars Goldsteins, Jari Koistin

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

人类 iPSC 衍生的海马细胞球体:一种用于对阿尔茨海默病患者特异性细胞表型进行分层和开发疗法的创新工具

Yuriy Pomeshchik, Oxana Klementieva, Jeovanis Gil, Isak Martinsson, Marita Grønning Hansen, Tessa de Vries, Anna Sancho-Balsells, Kaspar Russ, Ekaterina Savchenko, Anna Collin, Ana Rita Vaz, Silvia Bagnoli, Benedetta Nacmias, Claire Rampon, Sandro Sorbi, Dora Brites, György Marko-Varga, Zaal Kokaia,

Generation of an induced pluripotent stem cell line (CSC-46) from a patient with Parkinson's disease carrying a novel p.R301C mutation in the GBA gene

从携带 GBA 基因新型 p.R301C 突变的帕金森病患者体内生成诱导性多能干细胞系 (CSC-46)

Nadja Gustavsson, Ana Marote, Yuriy Pomeshchik, Kaspar Russ, Carla Azevedo, Margarita Chumarina, Stefano Goldwurm, Anna Collin, Luisa Pinto, António J Salgado, Oxana Klementieva, Laurent Roybon, Ekaterina Savchenko

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

长期白细胞介素 33 治疗可延缓肌萎缩侧索硬化症转基因小鼠模型的疾病发作并减轻星形胶质细胞活化

Paula Korhonen, Eveliina Pollari, Katja M Kanninen, Ekaterina Savchenko, Šárka Lehtonen, Sara Wojciechowski, Yuriy Pomeshchik, Ludo Van Den Bosch, Gundars Goldsteins, Jari Koistinaho, Tarja Malm

Generation of an induced pluripotent stem cell line (CSC-44) from a Parkinson's disease patient carrying a compound heterozygous mutation (c.823C>T and EX6 del) in the PARK2 gene

从携带 PARK2 基因复合杂合突变 (c.823C>T 和 EX6 del) 的帕金森病患者体内生成诱导性多能干细胞系 (CSC-44)

Ana Marote, Yuriy Pomeshchik, Stefano Goldwurm, Anna Collin, Nuno J Lamas, Luísa Pinto, António J Salgado, Laurent Roybon