日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation

尽管受体定位存在差异,但在β细胞中,具有相反偏向性的GLP-1受体激动剂可引起空间弥散的cAMP信号传导。

Chen, Shiqian; Lobato, Carolina B; Wong, Carissa; Manchanda, Yusman; Viloria, Katrina; Davies, Iona; Andersen, Daniel B; Ast, Julia; Sloop, Kyle W; Hodson, David J; Broichhagen, Johannes; Bloom, Steve; Holst, Jens J; Tan, Tricia; Tomas, Alejandra; Jones, Ben

Human class B1 GPCR modulation by plasma membrane lipids

人B1类GPCR受质膜脂质调控

Chao, Kin W; Wong, Linda; Oqua, Affiong I; Kalayan, Jas; Manchanda, Yusman; Gebbie-Rayet, James; Hedger, George; Tomas, Alejandra; Rouse, Sarah L

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function.

GLP-1R 与 ERMCSs 处的 VAPB 和 SPHKAP 结合,调节 β 细胞线粒体重塑和功能。

Austin Gregory, Oqua Affiong I, El Eid Liliane, Zhu Mingli, Manchanda Yusman, Peres Priyanka, Coyle Helena, Poliakova Yelyzaveta, Balkhiyarova Zhanna, Bouzakri Karim, Montoya Alex, Withers Dominic J, Solimena Michele, Jones Ben, Millership Steven J, Burgold Steffen, Gaboriau David C A, Majorovits Endre, Garlick Evelyn, do R B F Lima Maria Augusta, Prokopenko Inga, Nixon-Abell Jonathon, Müller Andreas, Tomas Alejandra

The physiological impact of an N-terminal Halo-tag on glucose-dependent insulinotropic polypeptide receptor function in mice

N端Halo标签对小鼠葡萄糖依赖性促胰岛素多肽受体功能的生理影响

Davies, Iona; Manchanda, Yusman; Sloop, Kyle W; Bloom, Stephen R; Tan, Tricia M-M; Tomas, Alejandra; Jones, Ben

Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001

新型 GLP-1R/GIPR 双重激动剂 HISHS-2001 的结合动力学、偏向性、受体内化及其对体外和体内胰岛素分泌的影响

Yusman Manchanda ,Ben Jones ,Gaelle Carrat ,Zenouska Ramchunder ,Piero Marchetti ,Isabelle Leclerc ,Rajamannar Thennati ,Vinod Burade ,Muthukumaran Natarajan ,Pradeep Shahi ,Alejandra Tomas ,Guy A Rutter

Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001

新型 GLP-1R/GIPR 双重激动剂的结合动力学、偏差、受体内化以及对体内和体外胰岛素分泌的影响,HISHS-2001

Yusman Manchanda, Ben Jones, Gaelle Carrat, Zenouska Ramchunder, Piero Marchetti, Isabelle Leclerc, Rajamannar Thennati, Vinod Burade, Muthukumaran Natarajan, Pradeep Shahi, Alejandra Tomas, Guy A Rutter

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function.

GLP-1R 与 ERMCSs 处的 VAPB 和 SPHKAP 结合,调节 β 细胞线粒体重塑和功能

Austin Gregory, Oqua Affiong I, El Eid Liliane, Zhu Mingli, Manchanda Yusman, Peres Priyanka, Coyle Helena, Poliakova Yelyzaveta, Bouzakri Karim, Montoya Alex, Withers Dominic J, Solimena Michele, Jones Ben, Millership Steven J, Burgold Steffen, Gaboriau David C A, Majorovits Endre, Garlick Evelyn, Lima Maria, Prokopenko Inga, Nixon-Abell Jonathon, Müller Andreas, Tomas Alejandra

Lipid regulation of the glucagon receptor family

脂质对胰高血糖素受体家族的调节

Oqua, Affiong Ika; Manchanda, Yusman; McGlone, Emma Rose; Jones, Ben; Rouse, Sarah; Tomas, Alejandra

Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice

成年 β 细胞特异性 β-arrestin 2 基因敲除小鼠中 GLP-1R 药理学反应存在不同的急性和长期反应

Stavroula Bitsi, Liliane El Eid, Yusman Manchanda, Affiong I Oqua, Nimco Mohamed, Ben Hansen, Kinga Suba, Guy A Rutter, Victoria Salem, Ben Jones, Alejandra Tomas

Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells

胰腺β细胞中GLP-1R与GIPR的内体信号增强和脱敏

Yusman Manchanda, Stavroula Bitsi, Shiqian Chen, Johannes Broichhagen, Jorge Bernardino de la Serna, Ben Jones, Alejandra Tomas