Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs
淀粉样蛋白的形成过程(而非淀粉样蛋白前体 (APP))胞内 C 末端结构域的产生需要由跨膜 GXXXG 基序组装的精确定向的 APP 二聚体
期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.M707142200
Pascal Kienlen-Campard, Bernadette Tasiaux, Joanne Van Hees, Mingli Li, Sandra Huysseune, Takeshi Sato, Jeffrey Z Fei, Saburo Aimoto, Pierre J Courtoy, Steven O Smith, Stefan N Constantinescu, Jean-Noël Octave