日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild-Type Ovarian Cancer Cells to Olaparib

转化生长因子β和上皮-间质转化改变同源重组修复基因表达并使BRCA野生型卵巢癌细胞对奥拉帕尼敏感

Cai M Roberts, Mehida Rojas-Alexandre, Ruth E Hanna, Z Ping Lin, Elena S Ratner

In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer

通过计算机筛选确定了一种新型小分子抑制剂,可抵消卵巢癌对 PARP 抑制剂的耐药性

Z Ping Lin, Nour N Al Zouabi #, Mark L Xu #, Nicole E Bowen, Terence L Wu, Ethan S Lavi, Pamela H Huang, Yong-Lian Zhu, Baek Kim, Elena S Ratner

Combination of triapine, olaparib, and cediranib suppresses progression of BRCA-wild type and PARP inhibitor-resistant epithelial ovarian cancer

三联疗法、奥拉帕尼和西地尼布可抑制 BRCA 野生型和 PARP 抑制剂耐药性上皮性卵巢癌的进展

Z Ping Lin, Yong-Lian Zhu, Ying-Chun Lo, Jake Moscarelli, Amy Xiong, Yasmin Korayem, Pamela H Huang, Smith Giri, Patricia LoRusso, Elena S Ratner

Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines

根据抗铂耐药和铂敏感卵巢癌细胞系的有效性对抗肿瘤药物进行分类

Kimiko Ishiguro, Yong-Lian Zhu, Z Ping Lin, Philip G Penketh, Krishnamurthy Shyam, Rui Zhu, Raymond P Baumann, Alan C Sartorelli, Thomas J Rutherford, Elena S Ratner

Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair

三苯氧胺通过破坏同源重组修复增强铂类联合疗法

Elena S Ratner, Yong-Lian Zhu, Philip G Penketh, Julie Berenblum, Margaret E Whicker, Pamela H Huang, Yashang Lee, Kimiko Ishiguro, Rui Zhu, Alan C Sartorelli, Z Ping Lin

MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib

MK-2206 使 BRCA 缺陷型上皮性卵巢腺癌对顺铂和奥拉帕尼敏感

Margaret E Whicker, Z Ping Lin, Ruth Hanna, Alan C Sartorelli, Elena S Ratner

Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes

由于三苯胺及其末端二甲基化衍生物 Dp44mT 的铜 (II) 配合物的活性丧失或增加,导致细胞死亡的机制不同

Kimiko Ishiguro, Z Ping Lin, Philip G Penketh, Krishnamurthy Shyam, Rui Zhu, Raymond P Baumann, Yong-Lian Zhu, Alan C Sartorelli, Thomas J Rutherford, Elena S Ratner

Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors

Triapine 破坏 CtIP 介导的同源重组修复,并使卵巢癌细胞对 PARP 和拓扑异构酶抑制剂敏感

Z Ping Lin #, Elena S Ratner #, Margaret E Whicker, Yashang Lee, Alan C Sartorelli

Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response

多药耐药蛋白 4 缺乏导致 cAMP 和前列腺素 E2 转运中断,从而改变 cAMP 介导的信号传导和伤害感受反应

Z Ping Lin, Yong-Lian Zhu, Dennis R Johnson, Kevin P Rice, Timothy Nottoli, Bryan C Hains, James McGrath, Stephen G Waxman, Alan C Sartorelli