Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice
异巴伐查尔酮通过自噬介导清除β-淀粉样蛋白并抑制原代星形胶质细胞和5x-FAD小鼠中的NLRP3炎症小体,从而改善阿尔茨海默病病理。
期刊:Frontiers in Pharmacology
影响因子:4.4
doi:10.3389/fphar.2025.1525364
Dilpreet Kour ,Parul Khajuria ,Kuhu Sharma ,Alpa Sharma ,Ankita Sharma ,Syed Mudassir Ali ,Priya Wazir ,P Ramajayan ,Sanghapal D Sawant ,Utpal Nandi ,Zabeer Ahmed ,Ajay Kumar
胶质细胞
炎性小体
炎症/感染
炎性小体
细胞生物学
阿尔茨海默症
自噬
炎症
NLRP3
免疫/内分泌
LRP3