Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)
利用结构引导设计直接作用的抗病毒药物，利用二甲基效应有效抑制严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 和中东呼吸综合征冠状病毒 (MERS-CoV) 的 3CL 蛋白酶
期刊:European Journal of Medicinal Chemistry
影响因子:6
doi:10.1016/j.ejmech.2023.115376
Chamandi S Dampalla, Matthew J Miller, Yunjeong Kim, Alexandria Zabiegala, Harry Nhat Nguyen, Trent K Madden, Hayden A Thurman, Alexandra J Machen, Anne Cooper, Lijun Liu, Kevin P Battaile, Scott Lovell, Kyeong-Ok Chang, William C Groutas
