日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Anti-HSP47 siRNA lipid nanoparticle ND-L02-s0201 reverses interstitial pulmonary fibrosis in preclinical rat models

抗HSP47 siRNA脂质纳米颗粒ND-L02-s0201可逆转临床前大鼠模型中的间质性肺纤维化

Liu, Yun; Liu, Jian; Quimbo, Alistair; Xia, Fengcheng; Yao, Jiping; Clamme, Jean-Pierre; Zabludoff, Sonya; Zhang, Jun; Ying, Wenbin

Anti-miR-17 therapy delays tumorigenesis in MYC-driven hepatocellular carcinoma (HCC)

抗miR-17疗法可延缓MYC驱动的肝细胞癌(HCC)的肿瘤发生

Dhanasekaran, Renumathy; Gabay-Ryan, Meital; Baylot, Virginie; Lai, Ian; Mosley, Adriane; Huang, Xinqiang; Zabludoff, Sonya; Li, Jian; Kaimal, Vivek; Karmali, Priya; Felsher, Dean W

Shift of microRNA profile upon glioma cell migration using patient-derived spheroids and serum-free conditions

使用患者来源的球体和无血清条件观察胶质瘤细胞迁移后 microRNA 谱的变化

Sune Munthe, Bo Halle, Henning B Boldt, Helle Christiansen, Steffen Schmidt, Vivek Kaimal, Jessica Xu, Sonya Zabludoff, Jan Mollenhauer, Frantz R Poulsen, Bjarne W Kristensen

miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells

miR-21抑制通过诱导CD24+祖细胞凋亡来减少肝纤维化并预防肿瘤发展

Zhang, Jing; Jiao, Jingjing; Cermelli, Silvia; Muir, Kyle; Jung, Kwang Hwa; Zou, Ruhai; Rashid, Asif; Gagea, Mihai; Zabludoff, Sonya; Kalluri, Raghu; Beretta, Laura

Anti-miR182 reduces ovarian cancer burden, invasion, and metastasis: an in vivo study in orthotopic xenografts of nude mice

Anti-miR182 降低卵巢癌负担、侵袭和转移:裸鼠原位异种移植体内研究

Xiaofei Xu, Bushra Ayub, Zhaojian Liu, Vanida Ann Serna, Wenan Qiang, Yugang Liu, Eva Hernando, Sonya Zabludoff, Takeshi Kurita, Beihua Kong, Jian-Jun Wei0

Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors

AZD7762(一种检查点激酶抑制剂)联合吉西他滨治疗美国晚期实体瘤患者的I期剂量递增研究

Sausville, Edward; Lorusso, Patricia; Carducci, Michael; Carter, Judith; Quinn, Mary F; Malburg, Lisa; Azad, Nilofer; Cosgrove, David; Knight, Richard; Barker, Peter; Zabludoff, Sonya; Agbo, Felix; Oakes, Patricia; Senderowicz, Adrian

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair

Chk1/2抑制剂AZD7762的放射增敏机制涉及G2检查点的阻断和同源重组DNA修复的抑制。

Morgan, Meredith A; Parsels, Leslie A; Zhao, Lili; Parsels, Joshua D; Davis, Mary A; Hassan, Maria C; Arumugarajah, Sankari; Hylander-Gans, Linda; Morosini, Deborah; Simeone, Diane M; Canman, Christine E; Normolle, Daniel P; Zabludoff, Sonya D; Maybaum, Jonathan; Lawrence, Theodore S

DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy

DNA损伤检测和修复途径——检查点激酶抑制剂在癌症治疗中的最新进展

Susan Ashwell, Sonya Zabludoff

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

AZD7762 是一种新型检查点激酶抑制剂,可促进检查点废除并增强 DNA 靶向疗法

Sonya D Zabludoff, Chun Deng, Michael R Grondine, Adam M Sheehy, Susan Ashwell, Benjamin L Caleb, Stephen Green, Heather R Haye, Candice L Horn, James W Janetka, Dongfang Liu, Elizabeth Mouchet, Shannon Ready, Judith L Rosenthal, Christophe Queva, Gary K Schwartz, Karen J Taylor, Archie N Tse, Graem

Cloning of mid-G1 serum response genes and identification of a subset regulated by conditional myc expression

克隆G1期血清反应基因并鉴定受条件性myc表达调控的子集

Tavtigian, S V; Zabludoff, S D; Wold, B J