日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Optimal Duration of Androgen Deprivation Therapy With Definitive Radiotherapy for Localized Prostate Cancer: A Meta-Analysis

局部前列腺癌根治性放疗联合雄激素剥夺疗法的最佳疗程:一项荟萃分析

Zaorsky, Nicholas G; Sun, Yilun; Nabid, Abdenour; Zapatero, Almudena; Bolla, Michel; Joseph, David; Maingon, Philippe; Guerrero, Araceli; Gonzalez, Ana Alvarez; San-Segundo, Carmen Gonzalez; Cabeza Rodríguez, Maria Ángeles; Sole, Josep Maria; Olivé, Agustí Pedro; Steigler, Allison; Souhami, Luis; Carrier, Nathalie; Armstrong, John G; Gillham, Charles; Pisansky, Thomas M; Schipper, Matthew; Sandler, Howard M; Efstathiou, Jason A; Lawton, Colleen; de Reijke, Theo M; Attard, Gerhardt; Roy, Soumyajit; Morgan, Scott C; Malone, Shawn; Hall, William A; Nguyen, Paul L; Shoag, Jonathan E; Vince, Randy A Jr; Calaway, Adam; Garcia, Jorge A; Barata, Pedro C; Mendiratta, Prateek; Brown, Jason R; Valle, Luca; Rettig, Matthew; Dess, Robert T; Jackson, William C; Martin, Ting; Jia, Angela Y; Steinberg, Michael; Romero, Tahmineh; Kishan, Amar U; Spratt, Daniel E

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models

在SARS-CoV-2和MERS感染模型中发现具有增强脑暴露和强效口服疗效的冠状病毒主要蛋白酶抑制剂

Lizzadro, Luca; Li, Jiapeng; Taha, Taha Y; Degotte, Gilles; Detomasi, Tyler C; Zapatero-Belinchon, Francisco J; Hantz, Eric R; Huang, Sijie; Matsui, Yusuke; Henderson, Will R; McCann, Jack T; Montano, Mauricio; Rosecrans, Julia; Torres Pomares, Daniel F; McGovern, Briana L; Diaz-Tapia, Randy; Benjamin, Jared; Gordon, Mary E; Suazo, Isidora D; Settineri, Nicholas S; Diallo, Amy; Krogan, Nevan J; Shoichet, Brian K; Verba, Kliment A; Albrecht, Randy; García-Sastre, Adolfo; White, Kris M; Ott, Melanie; Craik, Charles S; Renslo, Adam R

NRF2 activators and the inhibitor of nuclear export, selinexor, restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1 through an NRF2-independent mechanism.

NRF2 激活剂和核输出抑制剂 selinexor 通过一种不依赖于 NRF2 的机制,靶向涉及 ACE2、TMPRSS2 和 XPO1 的网络,从而限制冠状病毒。

Waqas Fakhar H, Silva da Costa Leandro, Zapatero-Belinchón Francisco J, Carter-Timofte Madalina E, Lasswitz Lisa, van der Horst Demi, Möller Rebecca, Dahlmann Julia, Olmer Ruth, Geffers Robert, Gerold Gisa, Olagnier David, Pessler Frank

Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell-Mediated Immunomodulation

表型分析揭示多模式γδ T细胞毒性是克服癌细胞介导的免疫调节的一种策略

Callum Baird Nattress ,Rhianna O'Sullivan ,Daniel Fowler ,Colin Hutton ,Petra Vlckova ,Jahangir Sufi ,Magdalena Buschhaus ,Ewa Basiarz ,Maria Ramos Zapatero ,Ferran Cardoso Rodriguez ,Xiao Qin ,Ashley Campbell ,Angeliki Kanouta ,Vivian S W Li ,Kerry Chester ,John Anderson ,Marta Barisa ,Jonathan P H Fisher ,Christopher J Tape

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy

基于结构的、具有高效体内疗效的高生物利用度、共价、广谱冠状病毒MPro抑制剂的发现

Tyler C Detomasi ,Gilles Degotte ,Sijie Huang ,Rahul K Suryawanshi ,Amy Diallo ,Luca Lizzadro ,Francisco J Zapatero-Belinchón ,Taha Y Taha ,Jiapeng Li ,Alicia L Richards ,Eric R Hantz ,Zain Alam ,Mauricio Montano ,Maria McCavitt-Malvido ,Rajesh Gumpena ,James R Partridge ,Galen J Correy ,Yusuke Matsui ,Annemarie F Charvat ,Isabella S Glenn ,Julia Rosecrans ,Jezrael L Revalde ,Dashiell Anderson ,Judd F Hultquist ,Michelle R Arkin ,R Jeffrey Neitz ,Danielle L Swaney ,Nevan J Krogan ,Brian K Shoichet ,Kliment A Verba ,Melanie Ott ,Adam R Renslo ,Charles S Craik

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

Mac1 ADP-核糖水解酶是SARS-CoV-2的治疗靶点。

Suryawanshi, Rahul K; Jaishankar, Priyadarshini; Correy, Galen J; Rachman, Moira M; O'Leary, Patrick C; Taha, Taha Y; Matsui, Yusuke; Zapatero-Belinchón, Francisco J; McCavitt-Malvido, Maria; Doruk, Yagmur U; Stevens, Maisie G V; Diolaiti, Morgan E; Jogalekar, Manasi P; Chen, Huadong; Richards, Alicia L; Kongpracha, Pornparn; Bali, Sofia; Montano, Mauricio; Rosecrans, Julia; Matthay, Michael; Togo, Takaya; Gonciarz, Ryan L; Gopalkrishnan, Saumya; Neitz, R Jeffrey; Krogan, Nevan J; Swaney, Danielle L; Shoichet, Brian K; Ott, Melanie; Renslo, Adam R; Ashworth, Alan; Fraser, James S

Low-Dose Hydrocortisone in Cirrhotic Patients With Septic Shock: A Double-Blind Randomised Placebo-Controlled Trial

低剂量氢化可的松治疗肝硬化合并脓毒性休克患者:一项双盲随机安慰剂对照试验

Meersseman, Philippe; Hernández-Tejero, María; Diaz, Juan Manuel; Wauters, Joost; Hermans, Greet; Aziz, Fátima; Ceunen, Helga; Prado, Veronica; Langouche, Lies; Arteaga, Mireya; Acevedo, Juan; Lleixa, Marc; Zapatero, Juliana; Toapanta, David; Arroyo, Vicente; Wilmer, Alexander; Fernandez, Javier

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.

携带 NSP6 中 L260F 突变的近期 SARS-CoV-2 变种增强了 RNA 复制和致病性

Taha Taha Y, Ezzatpour Shahrzad, Hayashi Jennifer M, Ye Chengjin, Zapatero-Belinchón Francisco J, Rosecrans Julia A, Kimmerly Gabriella R, Chen Irene P, Walcott Keith, Kurianowicz Anna, Jorgens Danielle M, Chaplin Natalie R, Choi Annette, Buchholz David W, Sahler Julie, Hilt Zachary T, Imbiakha Brian, Vagi-Szmola Cecilia, Montano Mauricio, Stevenson Erica, Gordon Martin, Swaney Danielle L, Krogan Nevan J, Whittaker Gary R, Martinez-Sobrido Luis, Aguilar Hector C, Ott Melanie

Models of Early Resistance to CDK4/6 Inhibitors Unveil Potential Therapeutic Treatment Sequencing.

CDK4/6抑制剂早期耐药模型揭示潜在的治疗顺序

Zapatero-Solana Elisabet, Ding Yan, Pulliam Nicholas, de Dios Alfonso, Ortiz-Ruiz Maria Jesus, Lallena María José

Visual Attention toward Patients with Hemifacial Microsomia Reconstruction: A Prospective Eye-Tracking Study

对接受半侧颜面短小症重建手术患者的视觉关注:一项前瞻性眼动追踪研究

Villavisanis, Dillan F; Workman, Clifford I; Zapatero, Zachary D; Vu, Giap H; Humphries, Stacey A; Cho, Daniel Y; Swanson, Jordan W; Bartlett, Scott P; Chatterjee, Anjan; Taylor, Jesse A