日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity.

发现并表征了具有强大髓系激活和抗肿瘤活性的首创 LIV1-TLR7/8 免疫调节偶联物

Yamazoe Sayumi, Poudel Yam, Sega Emanuela, Mukhopadhyay Anandaroop, Ramakrishnan Radha, Ukairo Okechukwu, Liu Scot, Akter Rahima, Sadanala Keerthi, Que Kathryn, Cheng Qinqin, Kotapati Srikanth, Deshpande Madhura, Cox Matthew, Chourey Shishir, Gupta Anuradha, Kempson James, Pabbisetty Kumar, Kaspady Mahammed, Bhattasali Debabrata, Yip Shiuhang, Wu Dauh-Rurng, Pookot Deepa, Li Yvonne, Kozhich Alexander, Drexler Dieter, Carl Stephen, Deyanova Ekaterina, Smith Michael, Chan Henry, West Sean, Diong S J, Chang Aram, Florin Lore, Mathur Arvind, Strop Pavel, Zapf Christoph W, Law Deborah, Wilson Nicholas, Broz Miranda, Chekler Eugene P

Development of a Buchwald-Hartwig Amination for an Accelerated Library Synthesis of Cereblon Binders

开发一种用于加速合成 Cereblon 结合剂库的 Buchwald-Hartwig 胺化反应

Lejava, Anastasia; Miseo, Giulianna A; Phan, Thomas; Zhu, Jinyi; Powers, Hannah L; Li, Jianqing; Mortensen, Deborah S; Zapf, Christoph W; Khambatta, Gody; Buenviaje, Jennifer; Holmberg-Douglas, Natalie

Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach

基于结构的新型TLR7/8激动剂有效载荷设计,可实现免疫调节偶联物策略

Poudel, Yam B; Lo, Julian C; Norris, Derek J; Cox, Matthew; He, Liqi; Johnson, Walter L; A M Subbaiah, Murugaiah; Mondal, Santigopal; Thangavel, Soodamani; Subramani, Lakshumanan; Reddy, Maheswara; Jain, Suraksha; Weiss, Dahlia R; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Dhar, Payal; Li, Yvonne; Sega, Emanuela; Yamazoe, Sayumi; Gavai, Ashvinikumar V; Mathur, Arvind; Zapf, Christoph W; Chekler, Eugene P

Leveraging efficiency metrics for the optimization of CELMoDs™ as cereblon-based molecular glue degraders

利用效率指标优化 CELMoDs™ 作为基于 cereblon 的分子胶降解剂

Jia, Lei; Riggs, Jennifer R; Weiss, Dahlia R; Claus, Brian L; Shanmugasundaram, Veerabahu; Johnson, Stephen R; Zapf, Christoph W

Chemoselective Electrosynthesis Using Rapid Alternating Polarity

利用快速交替极性进行化学选择性电合成

Kawamata, Yu; Hayashi, Kyohei; Carlson, Ethan; Shaji, Shobin; Waldmann, Dirk; Simmons, Bryan J; Edwards, Jacob T; Zapf, Christoph W; Saito, Masato; Baran, Phil S

Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning

氨基吡唑羧酰胺类布鲁顿酪氨酸激酶抑制剂。不可逆到可逆共价反应基团调控

Schnute, Mark E; Benoit, Stephen E; Buchler, Ingrid P; Caspers, Nicole; Grapperhaus, Margaret L; Han, Seungil; Hotchandani, Rajeev; Huang, Nelson; Hughes, Robert O; Juba, Brian M; Kim, Kyung-Hee; Liu, Erica; McCarthy, Erin; Messing, Dean; Miyashiro, Joy S; Mohan, Shashi; O'Connell, Thomas N; Ohren, Jeffrey F; Parikh, Mihir D; Schmidt, Michelle; Selness, Shaun R; Springer, John R; Thanabal, Venkataraman; Trujillo, John I; Walker, Daniel P; Wan, Zhao-Kui; Withka, Jane M; Wittwer, Arthur J; Wood, Nancy L; Xing, Li; Zapf, Christoph W; Douhan, John 3rd