日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fab-Fc and Fab-Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG(1) antibodies

Fab-Fc 和 Fab-Fab 相互作用的强度和价态各不相同,这导致了 IgG(1) 抗体的高浓度粘度。

Heisler, Joel; Hofmann, Jennifer L; Tan, Zhenyu; Zarzar, Jonathan; Izadi, Saeed; Carter, Paul J

Characterization of free light chain impurity in a bispecific antibody

双特异性抗体中游离轻链杂质的表征

Sadek, Monica; Mantha, Neelima; Lippold, Steffen; Li, Delia; Spitler, Kyle; Li, Ran; Spinosa, Phillip; Liu, Bob; Luu, Steven; Woon, Nicholas; Zhang, Yeying; Guo, Jia; Yang, Renee; Zarzar, Jonathan; Yang, Yi

Modulation of the high concentration viscosity of IgG(1) antibodies using clinically validated Fc mutations

利用临床验证的Fc突变调节IgG(1)抗体的高浓度粘度

Heisler, Joel; Kovner, Daniel; Izadi, Saeed; Zarzar, Jonathan; Carter, Paul J

High concentration formulation developability approaches and considerations

高浓度制剂的开发方法和注意事项

Zarzar, Jonathan; Khan, Tarik; Bhagawati, Maniraj; Weiche, Benjamin; Sydow-Andersen, Jasmin; Alavattam, Sreedhara

Deciphering deamidation and isomerization in therapeutic proteins: Effect of neighboring residue.

解读治疗性蛋白质中的脱酰胺和异构化:邻近残基的影响

Irudayanathan Flaviyan Jerome, Zarzar Jonathan, Lin Jasper, Izadi Saeed

Targeting lentiviral vector to specific cell types through surface displayed single chain antibody and fusogenic molecule

通过表面展示的单链抗体和融合分子将慢病毒载体靶向特定细胞类型

Lei, Yuning; Joo, Kye-Il; Zarzar, Jonathan; Wong, Clement; Wang, Pin