日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism

抗结合胆汁酸norUDCA可治愈肝纤维化,但会损害全身能量代谢。

Evangelakos, Ioannis; Verkade, Esther; Rohde, Julia K; Zaufel, Alex; Vargek, Martin; Heine, Markus; Worthmann, Anna; Graute, Sebastian; Manka Fuh, Marceline; Gunasekaran, Karthikeyan; Kumari, Manju; Schwinge, Dorothee; von Bergen, Martin; Rolle-Kampczyk, Ulrike; Engelmann, Beatrice; Breinbauer, Rolf; Fuerst, Rita; Saleem, Umber; de Boer, Jan Freark; Schlein, Christian; Hansen, Arne; Scheja, Ludger; Kuipers, Folkert; Moustafa, Tarek; Heeren, Joerg

A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development

转分化和程序性细胞死亡启动之间的一个决定点控制着KRAS依赖性胰腺癌的发展。

Anne T Schneider ,Christiane Koppe ,Emilie Crouchet ,Aristeidis Papargyriou ,Michael T Singer ,Veronika Büttner ,Leonie Keysberg ,Marta Szydlowska ,Frank Jühling ,Julien Moehlin ,Min-Chun Chen ,Valentina Leone ,Sebastian Mueller ,Thorsten Neuß ,Mirco Castoldi ,Marina Lesina ,Frank Bergmann ,Thilo Hackert ,Katja Steiger ,Wolfram T Knoefel ,Alex Zaufel ,Jakob N Kather ,Irene Esposito ,Matthias M Gaida ,Ahmed Ghallab ,Jan G Hengstler ,Henrik Einwächter ,Kristian Unger ,Hana Algül ,Nikolaus Gassler ,Roland M Schmid ,Roland Rad ,Thomas F Baumert ,Maximilian Reichert ,Mathias Heikenwalder ,Vangelis Kondylis # ,Mihael Vucur # ,Tom Luedde #

Intracellular Sphingosine-1-Phosphate Induces Lipolysis Through Direct Activation of Protein Kinase C Zeta.

细胞内鞘氨醇-1-磷酸通过直接激活蛋白激酶C Zeta诱导脂肪分解

Weske Sarah, Nowak Melissa Kim, Zaufel Alex, Esser Lea, Peter Christoph, Walz Lisa, Kühn Helena, Wolde Tsyon, Hoppe Julia, Schröder Nathalie Hannelore, Buschmann Tobias, Wollnitzke Philipp, Levkau Bodo

The role of LSR gene variants in early onset intrahepatic cholestasis: a case series with treatment options

LSR基因变异在早发性肝内胆汁淤积症中的作用:病例系列及治疗方案

Ohlsson, Sinja; Zaufel, Alex; Qvartskhava, Natalia; Stock, Friedrich; Hinreiner, Sophie; Baba, Hideo A; Prusinskas, Benas; Kubitz, Ralf; Görg, Boris; Herebian, Diran; Lainka, Elke; Kathemann, Simone

Rapid Selection of Sotrovimab Escape Variants in Severe Acute Respiratory Syndrome Coronavirus 2 Omicron-Infected Immunocompromised Patients

在感染严重急性呼吸综合征冠状病毒2 Omicron的免疫功能低下患者中快速筛选索特罗维单抗逃逸变异株

Gliga, Smaranda; Lübke, Nadine; Killer, Alexander; Gruell, Henning; Walker, Andreas; Dilthey, Alexander T; Thielen, Alexander; Lohr, Carolin; Flaßhove, Charlotte; Krieg, Sarah; Pereira, Joanna Ventura; Seraphin, Tobias Paul; Zaufel, Alex; Däumer, Martin; Orth, Hans-Martin; Feldt, Torsten; Bode, Johannes G; Klein, Florian; Timm, Jörg; Luedde, Tom; Jensen, Björn-Erik Ole

Ileal bile acid transporter inhibition in Cyp2c70 KO mice ameliorates cholestatic liver injury

抑制 Cyp2c70 KO 小鼠的回肠胆汁酸转运蛋白可改善胆汁淤积性肝损伤

Jennifer K Truong, Ashley L Bennett, Caroline Klindt, Ajay C Donepudi, Sudarshan R Malla, Kimberly J Pachura, Alex Zaufel, Tarek Moustafa, Paul A Dawson, Saul J Karpen

The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice

肠道细菌 Extibacter muris 产生次级胆汁酸并影响无菌小鼠的肝脏生理

Theresa Streidl, Isabel Karkossa, Rafael R Segura Muñoz, Claudia Eberl, Alex Zaufel, Johannes Plagge, Robert Schmaltz, Kristin Schubert, Marijana Basic, Kai Markus Schneider, Mamdouh Afify, Christian Trautwein, René Tolba, Bärbel Stecher, Heidi L Doden, Jason M Ridlon, Josef Ecker, Tarek Moustafa, M

Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions

次级(异构)胆汁酸与内源性配体协同作用,在生理和病理条件下激活FXR。

Zaufel, Alex; van de Wiel, Sandra M W; Yin, Lu; Fauler, Günter; Chien, Daphne; Dong, Xinzhong; Gilmer, John F; Truong, Jennifer K; Dawson, Paul A; van de Graaf, Stan F J; Fickert, Peter; Moustafa, Tarek

Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1

胆汁酸通过 S1PR2、ERK 和 SF-1 增加胆汁血症小鼠的类固醇生成,并诱导肾上腺皮质 H295R 细胞分泌皮质醇

Lei Liu, Katrin Panzitt, Silvia Racedo, Martin Wagner, Wolfgang Platzer, Alex Zaufel, Verena Theiler-Schwetz, Barbara Obermayer-Pietsch, Helmut Müller, Gerald Höfler, Akos Heinemann, Gernot Zollner, Peter Fickert

Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism

肝受体同源物-1是甲基池代谢的关键决定因素

Martin Wagner, Sungwoo Choi, Katrin Panzitt, Jennifer L Mamrosh, Jae Man Lee, Alex Zaufel, Rui Xiao, Ruth Wooton-Kee, Marcus Ståhlman, Christopher B Newgard, Jan Borén, David D Moore