日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Regulated induced proximity targeting chimeras-RIPTACs-A heterobifunctional small molecule strategy for cancer selective therapies.

调控诱导邻近靶向嵌合体-RIPTACs-一种用于癌症选择性治疗的异双功能小分子策略

Raina Kanak, Forbes Chris D, Stronk Rebecca, Rappi Jonathan P Jr, Eastman Kyle J, Zaware Nilesh, Yu Xinheng, Li Hao, Bhardwaj Amit, Gerritz Samuel W, Forgione Mia, Hundt Abigail, King Madeline P, Posner Zoe M, Correia Allison D, McGovern Andrew, Puleo David E, Chenard Rebekka, Mousseau James J, Vergara J Ignacio, Garvin Ethan, Macaluso Jennifer, Martin Michael, Bassoli Kyle, Jones Kelli, Garcia Marco, Howard Katia, Yaggi Madeleine, Smith Levi M, Chen Jinshan M, Mayfield Andrew B, De Leon Cesar A, Hines John, Kayser-Bricker Katherine J, Crews Craig M

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

调节诱导邻近靶向嵌合体 (RIPTAC):一种选择性杀死癌细胞的新型异双功能小分子治疗策略

Kanak Raina, Chris D Forbes, Rebecca Stronk, Jonathan P Rappi Jr, Kyle J Eastman, Samuel W Gerritz, Xinheng Yu, Hao Li, Amit Bhardwaj, Mia Forgione, Abigail Hundt, Madeline P King, Zoe M Posner, Allison Denny, Andrew McGovern, David E Puleo, Ethan Garvin, Rebekka Chenard, Nilesh Zaware, James J Mous

Selective PP2A Enhancement through Biased Heterotrimer Stabilization

通过偏向异源三聚体稳定实现选择性 PP2A 增强

Daniel Leonard, Wei Huang, Sudeh Izadmehr, Caitlin M O'Connor, Danica D Wiredja, Zhizhi Wang, Nilesh Zaware, Yinghua Chen, Daniela M Schlatzer, Janna Kiselar, Nikhil Vasireddi, Stefan Schüchner, Abbey L Perl, Matthew D Galsky, Wenqing Xu, David L Brautigan, Egon Ogris, Derek J Taylor, Goutham Narla

Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma

血脑屏障通透性小分子蛋白磷酸酶 2A 激活剂在胶质母细胞瘤中的单一疗法疗效

Joni Merisaari, Oxana V Denisova, Milena Doroszko, Vadim Le Joncour, Patrik Johansson, William P J Leenders, David B Kastrinsky, Nilesh Zaware, Goutham Narla, Pirjo Laakkonen, Sven Nelander, Michael Ohlmeyer, Jukka Westermarck

Bromodomain biology and drug discovery

溴结构域生物学和药物发现

Zaware, Nilesh; Zhou, Ming-Ming

Na(+) and Cl(-) induce differential physiological, biochemical responses and metabolite modulations in vitro in contrasting salt-tolerant soybean genotypes

Na(+) 和 Cl(-) 在体外对不同耐盐大豆基因型产生不同的生理、生化反应和代谢物调节作用。

Shelke, Deepak B; Nikalje, Ganesh C; Chambhare, Mahadev R; Zaware, Balkrishna N; Penna, Suprasanna; Nikam, Tukaram D

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

蛋白磷酸酶 2A 的小分子激活剂用于治疗去势抵抗性前列腺癌

Kimberly McClinch #, Rita A Avelar #, David Callejas #, Sudeh Izadmehr #, Danica Wiredja, Abbey Perl, Jaya Sangodkar, David B Kastrinsky, Daniela Schlatzer, Maxwell Cooper, Janna Kiselar, Agnes Stachnik, Shen Yao, Divya Hoon, Daniel McQuaid, Nilesh Zaware, Yixuan Gong, David L Brautigan, Stephen R P

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

肿瘤抑制蛋白PP2A的激活抑制KRAS驱动的肿瘤生长

Jaya Sangodkar ,Abbey Perl ,Rita Tohme ,Janna Kiselar ,David B Kastrinsky ,Nilesh Zaware ,Sudeh Izadmehr ,Sahar Mazhar ,Danica D Wiredja ,Caitlin M O'Connor ,Divya Hoon ,Neil S Dhawan ,Daniela Schlatzer ,Shen Yao ,Daniel Leonard ,Alain C Borczuk ,Giridharan Gokulrangan ,Lifu Wang ,Elena Svenson ,Caroline C Farrington ,Eric Yuan ,Rita A Avelar ,Agnes Stachnik ,Blake Smith ,Vickram Gidwani ,Heather M Giannini ,Daniel McQuaid ,Kimberly McClinch ,Zhizhi Wang ,Alice C Levine ,Rosalie C Sears ,Edward Y Chen ,Qiaonan Duan ,Manish Datt ,Shozeb Haider ,Avi Ma'ayan ,Analisa DiFeo ,Neelesh Sharma ,Matthew D Galsky ,David L Brautigan ,Yiannis A Ioannou ,Wenqing Xu ,Mark R Chance ,Michael Ohlmeyer ,Goutham Narla

AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization

AG311,一种复合物 I 的小分子抑制剂和缺氧诱导的 HIF-1α 稳定剂

Anja Bastian, Satoshi Matsuzaki, Kenneth M Humphries, Gavin A Pharaoh, Arpit Doshi, Nilesh Zaware, Aleem Gangjee, Michael A Ihnat

Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents

5-(芳基硫代)-9H-嘧啶并[4,5-b]吲哚-2,4-二胺的合成及作为受体酪氨酸激酶和胸苷酸合成酶抑制剂以及抗肿瘤药物的评价

Zaware, Nilesh; Kisliuk, Roy; Bastian, Anja; Ihnat, Michael A; Gangjee, Aleem