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Combination Cancer Treatment: Using Engineered DNAzyme Molecular Machines for Dynamic Inter- and Intracellular Regulation

联合癌症治疗：利用工程化DNA酶分子机器进行动态的细胞间和细胞内调控

期刊:Angewandte Chemie-International Edition

影响因子:16.9

doi:10.1002/anie.202210935

Qian, Ruo-Can; Zhou, Ze-Rui; Wu, Yuting; Yang, Zhenglin; Guo, Weijie; Li, Da-Wei; Lu, Yi

ACT001 inhibits pituitary tumor growth by inducing autophagic cell death via MEK4/MAPK pathway

ACT001 通过 MEK4/MAPK 通路诱导自噬细胞死亡，抑制垂体瘤生长

期刊:Acta Pharmacologica Sinica

影响因子:6.9

doi:10.1038/s41401-021-00856-5

Lin Cai #, Ze-Rui Wu #, Lei Cao #, Jia-Dong Xu, Jiang-Long Lu, Cheng-de Wang, Jing-Hao Jin, Zhe-Bao Wu, Zhi-Peng Su

Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours

lncRNA H19通过破坏垂体肿瘤中4E-BP1/Raptor相互作用来抑制mTORC1

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-018-06853-3

Ze Rui Wu,Lichong Yan,Yan Ting Liu,Lei Cao,Yu Hang Guo,Yong Zhang,Hong Yao,Lin Cai,Han Bing Shang,Wei Wei Rui,Gang Yang,Xiao Biao Zhang,Hao Tang,Yu Wang,Jin Yan Huang,Yong Xu Wei,Wei Guo Zhao,Bing Su,Zhe Bao Wu

Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death

DRD5（多巴胺受体 D5）的激活通过自噬细胞死亡抑制肿瘤生长

期刊:Autophagy

影响因子:14.6

doi:10.1080/15548627.2017.1328347

Zhi Gen Leng, Shao Jian Lin, Ze Rui Wu, Yu Hang Guo, Lin Cai, Han Bing Shang, Hao Tang, Ya Jun Xue, Mei Qing Lou, Wenxiu Zhao, Wei-Dong Le, Wei Guo Zhao, Xun Zhang, Zhe Bao Wu

Synthetic transmembrane DNA receptors enable engineered sensing and actuation

合成跨膜DNA受体可实现工程化传感和驱动

Combination Cancer Treatment: Using Engineered DNAzyme Molecular Machines for Dynamic Inter- and Intracellular Regulation

联合癌症治疗：利用工程化DNA酶分子机器进行动态的细胞间和细胞内调控

ACT001 inhibits pituitary tumor growth by inducing autophagic cell death via MEK4/MAPK pathway

ACT001 通过 MEK4/MAPK 通路诱导自噬细胞死亡，抑制垂体瘤生长

Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours

lncRNA H19通过破坏垂体肿瘤中4E-BP1/Raptor相互作用来抑制mTORC1

Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death

DRD5（多巴胺受体 D5）的激活通过自噬细胞死亡抑制肿瘤生长