日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combined treatment with CDK4/6, CDK2, and CXCR1/2 inhibitors effectively halts the growth of BRAF wild-type melanoma tumors.

CDK4/6、CDK2 和 CXCR1/2 抑制剂联合治疗可有效阻止 BRAF 野生型黑色素瘤肿瘤的生长

Yang Jinming, Luo Weifeng, Ward Patricia, Chen Sheau-Chiann, Zebala John, Maeda Dean, Yan Chi, Richmond Ann

Inhibition of the chemokine receptors CXCR1 and CXCR2 synergizes with docetaxel for effective tumor control and remodeling of the immune microenvironment of HPV-negative head and neck cancer models

趋化因子受体 CXCR1 和 CXCR2 的抑制与多西他赛协同作用,可有效控制肿瘤并重塑 HPV 阴性头颈癌模型的免疫微环境

Lucas A Horn #, Hanne Lind #, Kristen Fousek, Haiyan Qin, Nika Rajabian, Shantel Angstadt, Nicole Hsiao-Sanchez, Miriam M Medina-Enriquez, Marcus D Kelly, Clint T Allen, Sarah M Hammoudeh, Roberto Weigert, Dean Y Maeda, John A Zebala, Claudia Palena

CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth

黑色素瘤发生过程中CXCR2的表达控制着促进肿瘤生长的转录程序。

Yang, J; Bergdorf, K; Yan, C; Luo, W; Chen, S C; Ayers, G D; Liu, Q; Liu, X; Boothby, M; Weiss, V L; Groves, S M; Oleskie, A N; Zhang, X; Maeda, D Y; Zebala, J A; Quaranta, V; Richmond, A

Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer

靶向 T 细胞检查点 41BB 和 LAG3 以及髓系细胞 CXCR1/CXCR2 可在胰腺癌中产生抗肿瘤免疫力和持久反应

Pat Gulhati, Aislyn Schalck, Shan Jiang, Xiaoying Shang, Chang-Jiun Wu, Pingping Hou, Sharia Hernandez Ruiz, Luisa Solis Soto, Edwin Parra, Haoqiang Ying, Jincheng Han, Prasenjit Dey, Jun Li, Pingna Deng, Emi Sei, Dean Y Maeda, John A Zebala, Denise J Spring, Michael Kim, Huamin Wang, Anirban Maitra

Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC

SHP2 和 CXCR1/2 的联合抑制可促进 NSCLC 中的抗肿瘤 T 细胞反应

Kwan Ho Tang #, Shuai Li #, Alireza Khodadadi-Jamayran, Jayu Jen, Han Han, Kayla Guidry, Ting Chen, Yuan Hao, Carmine Fedele, John A Zebala, Dean Y Maeda, James G Christensen, Peter Olson, Argus Athanas, Cynthia A Loomis, Aristotelis Tsirigos, Kwok-Kin Wong #, Benjamin G Neel #

Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast

单细胞评估揭示了肿瘤免疫微环境的变化,这些变化塑造并维持了乳腺中的侵袭性病变。

Vidya C Sinha ,Amanda L Rinkenbaugh ,Mingchu Xu ,Xinhui Zhou ,Xiaomei Zhang ,Sabrina Jeter-Jones ,Jiansu Shao ,Yuan Qi ,John A Zebala ,Dean Y Maeda ,Florencia McAllister ,Helen Piwnica-Worms

Integrin-mediated interactions with a laminin-presenting substrate modulate biosynthesis and phenotypic expression for cells of the human nucleus pulposus

整合素介导的与层粘连蛋白呈递底物的相互作用调节人髓核细胞的生物合成和表型表达

J Speer, M Barcellona, L Jing, B Liu, M Lu, M Kelly, J Buchowski, L Zebala, S Luhmann, M Gupta, L Setton

Simultaneous inhibition of CXCR1/2, TGF-β, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity

同时抑制 CXCR1/2、TGF-β 和 PD-L1 可重塑肿瘤及其微环境,从而驱动抗肿瘤免疫

Lucas A Horn, Jeffrey Riskin, Heidi A Hempel, Kristen Fousek, Hanne Lind, Duane H Hamilton, Kristen K McCampbell, Dean Y Maeda, John A Zebala, Zhen Su, Jeffrey Schlom, Claudia Palena

Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

使用 CXCR1/2 抑制剂 SX-682 抑制 MDSC 运输可增强头颈癌模型中的 NK 细胞免疫疗法

Sarah Greene, Yvette Robbins, Wojciech K Mydlarz, Angel P Huynh, Nicole C Schmitt, Jay Friedman, Lucas A Horn, Claudia Palena, Jeffrey Schlom, Dean Y Maeda, John A Zebala, Paul E Clavijo, Clint Allen

Verteporfin treatment controls morphology, phenotype, and global gene expression for cells of the human nucleus pulposus

维替泊芬治疗可控制人髓核细胞的形态、表型和整体基因表达

Fearing, Bailey V; Speer, Julie E; Jing, Liufang; Kalathil, Aravind; P Kelly, Michael; M Buchowski, Jacob; P Zebala, Lukas; Luhmann, Scott; C Gupta, Munish; A Setton, Lori