日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PCSK9-mediated degradation of cell-surface LDL receptors impairs human CD8+ T cell effector functions.

PCSK9介导的细胞表面LDL受体降解会损害人类CD8+ T细胞效应功能。

Markovska Angela, Lommers Lara F, Bodelón Alejandra, Greve Patrick, van Vark-van der Zee Leonie C, Mulder Monique T, Roeters van Lennep Jeanine E, Zelcer Noam, Schipper Henk S, Boes Marianne

Open-source sub-nanometer stabilization system for super-resolution fluorescence microscopy

用于超分辨率荧光显微镜的开源亚纳米级稳定系统

Edorna, Florencia; Choque, Florencia D; Ferrari, Giovanni; Masullo, Luciano A; Zdańkowski, Piotr; Acuna, Guillermo P; Tinnefeld, Philip; Szalai, Alan M; Lopez, Lucía F; Zelcer, Andrés; Stefani, Fernando D

Cholesterol homeostasis and lipid raft dynamics at the basis of tumor-induced immune dysfunction in chronic lymphocytic leukemia.

胆固醇稳态和脂筏动力学是慢性淋巴细胞白血病肿瘤诱导免疫功能障碍的基础

Jacobs Chaja F, Peters Fleur S, Camerini Elena, Cretenet Gaspard, Rietveld Joanne, Schomakers Bauke V, van Weeghel Michel, Hahn Nico, Verberk Sanne G S, Van den Bossche Jan, Langeveld Mirjam, Kleijwegt Fleur, Eldering Eric, Zelcer Noam, Kater Arnon P, Simon-Molas Helga

UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation.

UBE3A 通过靶向 ABCA1 进行蛋白酶体降解,促进泡沫细胞形成并抑制髓鞘再生

Loix Melanie, Vanherle Sam, Bolkaerts Laura, Verberk Sanne G S, Punt Mattijs, Wouters Flore, Moonen Brecht, Verhagen Rob, Van Wouw Suzanne A E, Jongejan Aldo, Distel Ben, Elgersma Ype, Haidar Mansour, Zelcer Noam, Hendriks Jerome J A, Bogie Jeroen F J

The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice

人工设计的细胞因子IC7Fc通过靶向小鼠高脂血症来减缓动脉粥样硬化的发展。

Wietse In Het Panhuis ,Ellen Thiemann ,Daisy M A H van Dijk ,Bibian Been ,Kelsey E Jarrett ,Amber Meurs ,Sander Kooijman ,Milaine V Hovingh ,Melanie Modder ,Bram W van Os ,Thijs J Sluiter ,Niek Blomberg ,Amanda C M Pronk ,Salwa Afkir ,Trea C M Streefland ,Reshma A Lalai ,Maria O Taveras ,Sen Zhang ,Timothy E Adams ,Lauren V Terry ,Sarah M Turpin-Nolan ,Margreet R de Vries ,Martin Giera ,Stefan Rose-John ,Noam Zelcer ,Jan Freark de Boer ,Thomas Q de Aguiar Vallim ,Mark A Febbraio ,Patrick C N Rensen ,Milena Schönke

Structural basis for substrate selectivity by site-one protease revealed by studies with a small-molecule inhibitor

利用小分子抑制剂的研究揭示了位点一蛋白酶底物选择性的结构基础

Bullington, Ashley V; Micallo, Ilaria; Bajaj, Bilkish; Kumar, Pankaj; Schlamowitz, Netanya; Silva, Aurora; Hendrix, Sebastian; Zelcer, Noam; Kober, Daniel L

NPC1 trafficking via VPS41-dependent LAMP carriers regulates endosomal cholesterol homeostasis

NPC1通过VPS41依赖的LAMP载体进行运输,从而调节内体胆固醇稳态。

Ndoj, Klevis; Tantucci, Matteo; Sanza, Paolo; Zubak, Kristian; Marodin, Giorgia; Kingma, Jenina; Snijder, Felix; Veenendaal, Tineke; Kober, Daniel L; Zelcer, Noam; Klumperman, Judith

Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET.

PROTAC介导的整合膜蛋白EGFR和c-MET降解的正交验证

Ruffilli Camilla, Röth Sascha, Zelcer Noam, Moreau Kevin

SPRINGing off the lock: the role of SPRING in S1P activity and SREBP-regulated lipid metabolism

挣脱束缚:SPRING 在 S1P 活性和 SREBP 调控的脂质代谢中的作用

Micallo, Ilaria; Bullington, Ashley V; Kober, Daniel L; Zelcer, Noam

SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain

SPRING 通过取代抑制性前结构域,允许 S1P 介导 SREBP2 裂解

Sebastian Hendrix, Vincent Dartigue, Hailee Hall, Shrankhla Bawaria, Jenina Kingma, Bilkish Bajaj, Noam Zelcer, Daniel L Kober