Zenitsky相关文献与解析，生知库 | 链接生命科学的每一步

Bargues-Carot, Alejandra; Kondru, Naveen; Haller, Maddlyn; Zenitsky, Gary; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Arthi; Kanthasamy, Anumantha G

毒理研究

帕金森

神经科学

发表日期：2026

文献求助收藏

Preclinical Evaluation of Synthetic Biology-Driven Engineered Escherichia coli Nissle 1917 as a Living Therapeutic for Sustained L-DOPA Delivery

利用合成生物学方法改造的大肠杆菌 Nissle 1917 作为持续递送左旋多巴的活体疗法的临床前评估

期刊:ACS Synthetic Biology

影响因子:3.9

doi:10.1021/acssynbio.5c00786

Abdalla, Ahmed; Padhi, Piyush; Bakes, Nicholas; Thyer, Ross; Zenitsky, Gary; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Arthi; Ellington, Andrew D; Phillips, Gregory J; Kanthasamy, Anumantha G

发表日期：2026

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Bioengineered gut bacterium synthesizing levodopa alleviates motor deficits in models of Parkinson's disease

生物工程改造的肠道细菌合成左旋多巴可缓解帕金森病模型中的运动障碍

期刊:Cell Host & Microbe

影响因子:18.7

doi:10.1016/j.chom.2025.10.005

Padhi, Piyush; Abdalla, Ahmed; Schneider, Benjamin; Backes, Nick; Otto, Alyssa A; Scheibe, Ileia J; Thomas, Jacob P; Khadse, Gargi; Samidurai, Manikandan; Jochmans, Alexander K; George, Amanda; Zenitsky, Gary; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Arthi; Mishra, Aditya; Allenspach, Karin; Mochel, Jonathan; Phillips, Gregory J; Kanthasamy, Anumantha G

Pathological Î±-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.

病理性α-突触核蛋白失调表观转录组写入蛋白METTL3，从而驱动小胶质细胞中的神经炎症

期刊:Cell Reports

影响因子:6.9

doi:10.1016/j.celrep.2025.115618

Miller Cameron, Ealy Alyssa, Gregory Amanda, Janarthanam Chelva, Albers William, Richardson Gabriel, Jin Huajun, Zenitsky Gary, Anantharam Vellareddy, Kanthasamy Arthi, Kanthasamy Anumantha G

Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCÎ´ and Lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-related neurodegenerative diseases.

线粒体应激通过蛋白水解激活 PKCÎ´ 和 Lamin B1 磷酸化神经元细胞中的核结构来破坏：对与年龄相关的神经退行性疾病的发病机制具有重要意义

期刊:Frontiers in Cellular Neuroscience

影响因子:4

doi:10.3389/fncel.2025.1549265

Charli Adhithiya, Chang Yuan-Teng, Luo Jie, Palanisamy Bharathi, Malovic Emir, Riaz Zainab, Miller Cameron, Samidurai Manikandan, Zenitsky Gary, Jin Huajun, Anantharam Vellareddy, Kanthasamy Arthi, Kanthasamy Anumantha G

KCa3.1 Contributes to Neuroinflammation and Nigral Dopaminergic Neurodegeneration in Experimental models of Parkinson's Disease

KCa3.1在帕金森病实验模型中促进神经炎症和黑质多巴胺能神经退行性变。

期刊:

影响因子:

doi:10.1101/2025.03.18.643982

Samidurai, Manikandan; Chennakesavan, Karthick; Sarkar, Souvarish; Malovic, Emir; Nguyen, Hai M; Singh, Latika; Kumar, Anil; Ealy, Alyssa; Janarthanam, Chelva; Palanisamy, Bharathi Niveditha; Kondru, Naveen; Zenitsky, Gary; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Anumantha; Zhang, Hui; Wulff, Heike; Kanthasamy, Arthi

MicroRNA Expression in Asymptomatic Welders: Implications for Biomarker Discovery for Environmentally-Linked Neurodegenerative Disorders.

无症状焊工体内microRNA表达：对环境相关神经退行性疾病生物标志物发现的启示

期刊:

影响因子:

doi:10.1101/2025.02.10.25322027

Bargues-Carot Alejandra, Prado-Rico Janina, Kawasawa Yuka Imamura, Cai Jiazhang, Yanosky Jeff D, Zenitsky Gary, Jin Huajun, Lewis Mechelle, Ma Ping, Anantharam Vellareddy, Kanthasamy Arthi, Rico Andre Luis Garao, Hall Molly A, Mailman Richard B, Kanthasamy Anumantha G, Huang Xuemei

神经科学

发表日期：2025

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Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson's and other related neurodegenerative diseases

氧化应激诱导的神经退行性变中核孔和核质转运障碍：与帕金森病及其他相关神经退行性疾病发病机制的分子机制的相关性

期刊:Molecular Neurodegeneration

影响因子:17.5

doi:10.1186/s13024-024-00774-0

Riaz, Zainab; Richardson, Gabriel S; Jin, Huajun; Zenitsky, Gary; Anantharam, Vellareddy; Kanthasamy, Arthi; Kanthasamy, Anumantha G

Epitranscriptomic reader YTHDF2 regulates SEK1(MAP2K4)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress

表观转录组读取器 YTHDF2 在神经毒性应激期间调节星形胶质细胞中的 SEK1（MAP2K4）-JNK-cJUN 炎症信号

期刊:iScience

影响因子:4.6

doi:10.1016/j.isci.2024.110619

Emir Malovic, Alyssa Ealy, Cameron Miller, Ahyoung Jang, Phillip J Hsu, Souvarish Sarkar, Dharmin Rokad, Cody Goeser, Aleah Kristen Hartman, Allen Zhu, Bharathi Palanisamy, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Chuan He, Anumantha G Kanthasamy

Immunology/Inflammation

Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by Impairing Endosomal Trafficking and Protein Degradation Mechanisms

锰暴露通过损害内体运输和蛋白质降解机制增强外泌体中错误折叠的 α-突触核蛋白的释放

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms252212207

Dharmin Rokad, Dilshan S Harischandra, Manikandan Samidurai, Yuan-Teng Chang, Jie Luo, Vivek Lawana, Souvarish Sarkar, Bharathi N Palanisamy, Sireesha Manne, Dongsuk Kim, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Auriel Willette, Arthi Kanthasamy, Anumantha G Kanthasamy

细胞生物学

发表日期：2024

文献求助收藏

Neurotoxic Effect of Manganese and Vanadium Co-Exposure in Animal Models of Parkinson's Disease

锰和钒共同暴露对帕金森病动物模型的神经毒性作用

Preclinical Evaluation of Synthetic Biology-Driven Engineered Escherichia coli Nissle 1917 as a Living Therapeutic for Sustained L-DOPA Delivery

利用合成生物学方法改造的大肠杆菌 Nissle 1917 作为持续递送左旋多巴的活体疗法的临床前评估

Bioengineered gut bacterium synthesizing levodopa alleviates motor deficits in models of Parkinson's disease

生物工程改造的肠道细菌合成左旋多巴可缓解帕金森病模型中的运动障碍

Pathological Î±-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.

病理性α-突触核蛋白失调表观转录组写入蛋白METTL3，从而驱动小胶质细胞中的神经炎症

Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCÎ´ and Lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-related neurodegenerative diseases.

线粒体应激通过蛋白水解激活 PKCÎ´ 和 Lamin B1 磷酸化神经元细胞中的核结构来破坏：对与年龄相关的神经退行性疾病的发病机制具有重要意义

KCa3.1 Contributes to Neuroinflammation and Nigral Dopaminergic Neurodegeneration in Experimental models of Parkinson's Disease

KCa3.1在帕金森病实验模型中促进神经炎症和黑质多巴胺能神经退行性变。

MicroRNA Expression in Asymptomatic Welders: Implications for Biomarker Discovery for Environmentally-Linked Neurodegenerative Disorders.

无症状焊工体内microRNA表达：对环境相关神经退行性疾病生物标志物发现的启示

Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson's and other related neurodegenerative diseases

氧化应激诱导的神经退行性变中核孔和核质转运障碍：与帕金森病及其他相关神经退行性疾病发病机制的分子机制的相关性

Epitranscriptomic reader YTHDF2 regulates SEK1(MAP2K4)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress

表观转录组读取器 YTHDF2 在神经毒性应激期间调节星形胶质细胞中的 SEK1（MAP2K4）-JNK-cJUN 炎症信号

Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by Impairing Endosomal Trafficking and Protein Degradation Mechanisms

锰暴露通过损害内体运输和蛋白质降解机制增强外泌体中错误折叠的 α-突触核蛋白的释放