日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement function

RAY121 是一种经过基因工程改造的抗 C1s 抗体,具有 C1q 置换功能,可实现持久的补体中和作用。

Adrian W S Ho ,Taku Fukuzawa ,Hikaru Koga ,Ken Ohmine ,Hiroki Kawauchi ,Masaru Muraoka ,Yuri Ikuta ,Garvita Gupta ,Momoko Okuda ,Ichio Onami ,Miho Ayabe ,Akira Takeiri ,Hideyuki Konishi ,Yui Sugawara ,Shoko Usami ,Eriko Ito ,Norihito Shibahara ,Kazuhisa Ozeki ,Yukiko Wada ,Ayano Hirako ,Noriyuki Takahashi ,Zenjiro Sampei ,Kenta Haraya ,Naoaki Murao ,Takashi Fujii ,Takuya Torizawa ,Hideaki Shimada ,Tomoyuki Igawa

Monte Carlo Thompson sampling-guided design for antibody engineering

蒙特卡洛汤普森抽样指导抗体工程设计

Taro Kakuzaki, Hikaru Koga, Shuuki Takizawa, Shoichi Metsugi, Hirotake Shiraiwa, Zenjiro Sampei, Kenji Yoshida, Hiroyuki Tsunoda, Reiji Teramoto

Efficient production of bispecific antibody by FAST-IgTM and its application to NXT007 for the treatment of hemophilia A

FAST-IgTM高效生产双特异性抗体及其在NXT007治疗A型血友病中的应用

Hikaru Koga, Takashi Yamano, Juan Betancur, Satoko Nagatomo, Yousuke Ikeda, Kazuki Yamaguchi, Yoshiaki Nabuchi, Kazuki Sato, Yuri Teranishi-Ikawa, Motohiko Sato, Hiroyuki Hirayama, Akira Hayasaka, Takuya Torizawa, Kenta Haraya, Zenjiro Sampei, Hirotake Shiraiwa, Takehisa Kitazawa, Tomoyuki Igawa, Ta

Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+ T cell interleukin-2 secretion

通过检测 CD4+ T 细胞白细胞介素-2 的分泌,快速体外评估工程抗体疗法的免疫原性潜力

Yoshiyuki Arata, Shigeki Motoyama, Mariko Yano, Tatsuya Ikuno, Shunsuke Ito, Tomochika Matsushita, Akira Takeiri, Yukari Nishito, Nami Yabuki, Hideaki Mizuno, Zenjiro Sampei, Masayuki Mishima, Masaki Honda, Jumpei Kiyokawa, Hiromi Suzuki, Shuichi Chiba, Mitsuyasu Tabo, Chiyomi Kubo

Complement Activation by an Anti-Dengue/Zika Antibody with Impaired Fcγ Receptor Binding Provides Strong Efficacy and Abrogates Risk of Antibody-Dependent Enhancement

抗登革热/寨卡病毒抗体与 Fcγ 受体结合受损时,其补体激活具有很强的疗效,并消除了抗体依赖性增强的风险

Zenjiro Sampei, Christine Xing'er Koo, Frannie Jiuyi Teo, Ying Xiu Toh, Taku Fukuzawa, Siok Wan Gan, Takeru Nambu, Adrian Ho, Kiyofumi Honda, Tomoyuki Igawa, Fariyal Ahmed, Cheng-I Wang, Katja Fink, Junichi Nezu

Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

结合 pH 依赖性抗原结合和新型 Fc 工程消除食蟹猴血浆可溶性抗原

Yuji Hori, Ken Ohmine, Hitoshi Katada, Yuki Noguchi, Kazuki Sato, Takeru Nambu, Lam Runyi Adeline, Gan Siok Wan, Kenta Haraya, Kazuhisa Ozeki, Masahiko Nanami, Tatsuhiko Tachibana, Zenjiro Sampei, Taichi Kuramochi, Junichi Nezu, Kunihiro Hattori, Tomoyuki Igawa

Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody

抗体工程生成长效抗 C5 循环抗体 SKY59

Zenjiro Sampei, Kenta Haraya, Tatsuhiko Tachibana, Taku Fukuzawa, Meiri Shida-Kawazoe, Siok Wan Gan, Yuichiro Shimizu, Yoshinao Ruike, Shu Feng, Taichi Kuramochi, Masaru Muraoka, Takehisa Kitazawa, Yoshiki Kawabe, Tomoyuki Igawa, Kunihiro Hattori, Junichi Nezu

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases

SKY59是一种新型循环抗体,它能持久中和C5,这为补体介导疾病提供了一种潜在的治疗方法。

Taku Fukuzawa ,Zenjiro Sampei ,Kenta Haraya ,Yoshinao Ruike ,Meiri Shida-Kawazoe ,Yuichiro Shimizu ,Siok Wan Gan ,Machiko Irie ,Yoshinori Tsuboi ,Hitoshi Tai ,Tetsushi Sakiyama ,Akihisa Sakamoto ,Shinya Ishii ,Atsuhiko Maeda ,Yuki Iwayanagi ,Norihito Shibahara ,Mitsuko Shibuya ,Genki Nakamura ,Takeru Nambu ,Akira Hayasaka ,Futa Mimoto ,Yuu Okura ,Yuji Hori ,Kiyoshi Habu ,Manabu Wada ,Takaaki Miura ,Tatsuhiko Tachibana ,Kiyofumi Honda ,Hiroyuki Tsunoda ,Takehisa Kitazawa ,Yoshiki Kawabe ,Tomoyuki Igawa ,Kunihiro Hattori ,Junichi Nezu

Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity

模拟因子 VIII 辅因子活性的非对称双特异性 IgG 抗体的鉴定和多维优化

Zenjiro Sampei, Tomoyuki Igawa, Tetsuhiro Soeda, Yukiko Okuyama-Nishida, Chifumi Moriyama, Tetsuya Wakabayashi, Eriko Tanaka, Atsushi Muto, Tetsuo Kojima, Takehisa Kitazawa, Kazutaka Yoshihashi, Aya Harada, Miho Funaki, Kenta Haraya, Tatsuhiko Tachibana, Sachiyo Suzuki, Keiko Esaki, Yoshiaki Nabuchi