STING synergizes with TOX suppressing HO-1 expression to trigger ferroptosis in tumor-infiltrating CD8+ T cell and immunotherapy resistance
STING 与 TOX 协同抑制 HO-1 表达，从而诱导肿瘤浸润 CD8+ T 细胞发生铁死亡，并导致免疫治疗耐药。
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-69350-y
Zhu, Qian; Zhang, Jun-Bao; Nie, Cai-Ping; Liu, Xiu-Feng; Zhan, Liang-Ping; Li, Ming; Zeng, Xi-Liang; He, Jia; Huang, He; Xia, Xiao-Jun; Gao, Song; Zhang, Xiao-Shi; Li, Jiang
肿瘤
T细胞
肿瘤免疫
STING
治疗耐药
CD8
铁死亡
TOX
细胞生物学
免疫/内分泌
