文献库，生知库 | 链接生命科学的每一步

日期影响因子

Unveiling BCL-xL-specific PROTAC efficiency and dissociation pathways using native mass spectrometry

利用天然质谱法揭示 BCL-xL 特异性 PROTAC 效率和解离途径

期刊:Chemical Science

影响因子:7.4

doi:10.1039/d5sc07400b

Gadallah, Mohamed I; Nonhof, Kailyn L; Nayak, Digant; Zhang, Peiyi; Dioli, Olivia; Zheng, Guangrong; Olsen, Shaun K; Zhou, Daohong; Brodbelt, Jennifer S

发表日期：2026

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Integrated Microfluidic Chip Enabling Preparation and Immobilization of Cell-Laden Microspheres, and Microsphere-Based Cell Culture and Analysis

集成微流控芯片可实现细胞负载微球的制备和固定，以及基于微球的细胞培养和分析

期刊:Biosensors-Basel

影响因子:5.6

doi:10.3390/bios16020126

Mou, Qiongyao; Zhang, Peiyi; Li, Daijing; Wang, Qiong; Yang, Jun

细胞生物学

发表日期：2026

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The Combination of a BCL-xL PROTAC and an mTOR Inhibitor Sensitizes Pancreatic Ductal Adenocarcinoma to KRAS(G12D) Inhibitor Treatment

BCL-xL PROTAC 与 mTOR 抑制剂联合应用可增强胰腺导管腺癌对 KRAS(G12D) 抑制剂治疗的敏感性

影响因子:4.4

doi:10.3390/cancers18060920

Miyan, Javed; Vudatha, Vignesh; Cao, Lin; Zhang, Peiyi; Zheng, Guangrong; Zheng, Lei; Trevino, Jose; Zhou, Daohong; Khan, Sajid

发表日期：2026

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The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRAS(G12D) inhibitor treatment by enhancing apoptosis induction.

BCL-xL PROTAC 与 mTOR 抑制剂的联合作用可通过增强细胞凋亡诱导，使胰腺导管腺癌对 KRAS(G12D) 抑制剂治疗更加敏感。

doi:10.64898/2026.01.05.697773

Miyan Javed, Vudatha Vignesh, Cao Lin, Zhang Peiyi, Zheng Guangrong, Zheng Lei, Trevino Jose, Zhou Daohong, Khan Sajid

细胞生物学

发表日期：2026

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A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice

BCL-xL/BCL-2 PROTAC 能有效清除肝脏中的衰老细胞，并减少小鼠体内 MASH 驱动的肝细胞癌。

期刊:Nature Aging

影响因子:19.4

doi:10.1038/s43587-025-00811-7

Yang, Yang; Jn-Simon, Natacha; He, Yonghan; Sun, Chunbao; Zhang, Peiyi; Hu, Wanyi; Tian, Tian; Zeng, Huadong; Basha, Sreenivasulu; Huerta, Araceli S; Sun, Lu-Zhe; Yin, Xian-Ming; Hromas, Robert; Zheng, Guangrong; Pi, Liya; Zhou, Daohong

细胞生物学

发表日期：2025

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A novel regimen for pancreatic ductal adenocarcinoma targeting MEK, BCL-xL, and EGFR

一种靶向MEK、BCL-xL和EGFR的新型胰腺导管腺癌治疗方案

期刊:Neoplasia

影响因子:7.7

doi:10.1016/j.neo.2024.101070

Han, Song; Tushoski-Alemán, Gerik W; Zhang, Peiyi; Zheng, Guangrong; Zhou, Daohong; Huo, Zhiguang; Licht, Jonathan; George, Thomas J; Allegra, Carmen; Trevino, Jose G; Hughes, Steven J

发表日期：2025

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Discovery of Dual BCL-xL/BCL-w Degraders by Exploiting the Bis(sulfonyl)benzene Ring of ABT-263 as a Linkage Vector

利用ABT-263的双(磺酰基)苯环作为连接载体，发现双重BCL-xL/BCL-w降解剂

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5c01834

Poddar, Saikat K; Yang, Yang; Pal, Pratik; Jin, Zeng; Pei, Jing; Xiao, Yufeng; Hu, Wanyi; Zhang, Peiyi; Adekunbi, Praise; Thummuri, Dinesh; Yuan, Yaxia; Lv, Dongwen; Pelletier, J Peter R; Zhang, Weizhou; Zhou, Daohong; Zheng, Guangrong

发表日期：2025

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Discovery of XZ338, a highly potent BCL-X(L) degrader

发现高效BCL-X(L)降解剂XZ338

期刊:European Journal of Medicinal Chemistry

影响因子:5.9

doi:10.1016/j.ejmech.2025.117624

Zhang, Xuan; Thummuri, Dinesh; Hu, Wanyi; Liu, Xingui; Zhang, Peiyi; Zhou, Shuo; Zhou, Daohong; Zheng, Guangrong

发表日期：2025

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Ring Finger Protein 2 Promotes Oxidative Stress and Mitochondrial Dysfunction in Doxorubicin-Induced Cardiotoxicity Via the Mercaptopyruvate Sulfurtransferase/Hydrogen Sulfide Pathway.

Ring Finger Protein 2 通过巯基丙酮酸硫转移酶/硫化氢途径促进阿霉素诱导的心脏毒性中的氧化应激和线粒体功能障碍。

期刊:Journal of the American Heart Association

影响因子:5.3

doi:10.1161/JAHA.125.041440

Zhong Yi, Fan Di, Zhang Peiyi, Mao Xiaoxiang, Liu Baoqing, Wang Cheng, Li Qiubai

发表日期：2025

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Conditioned Medium Derived From Human Dental Follicle Mesenchymal Stem Cells Alleviates Macrophage Proinflammatory Responses Through MAPK-ERK-EGR1 Axis

源自人牙囊间充质干细胞的条件培养基通过 MAPK-ERK-EGR1 轴减轻巨噬细胞促炎反应

期刊:Stem Cells International

影响因子:3.8

doi:10.1155/sci/5514771

Chuhan Zhang, Peiyi Lv, Qiuying Liang, Jian Zhou, Buling Wu, Wenan Xu

发育与干细胞

发表日期：2024

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