日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A druggable redox switch on SHP1 controls macrophage inflammation

SHP1 上的可药物调控的氧化还原开关控制巨噬细胞炎症

Ng, Mei Ying; Nix, Meredith N; Du, Guangyan; Davidek, Ivan; Burger, Nils; Shin, Sanghee; Toenjes, Sean; Takeda, Haruna; Cheah Xin Yan, Megan; Zhang, Bingsen; Xiao, Haopeng; Wei, Shelley M; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Wales, Thomas E; Engen, John R; Mills, Evanna L; Che, Jianwei; Zhang, Tinghu; Gray, Nathanael S; Chouchani, Edward T

Genome characterization and comparative genomics of Limosilactobacillus reuteri HDB isolated from the gut of an Indian infant

对从印度婴儿肠道中分离出的罗伊氏乳杆菌HDB进行基因组特征分析和比较基因组学研究

Fu, Sipei; Wang, Lushun; Li, Veronica L; Lyu, Xuchao; Wei, Wei; Shi, Xu; Deng, Shuliang; Barber, Jacob L; Tahir, Usman A; Adams, Charleen; Carson, April; Hidalgo, Bertha; Raffield, Laura M; Wilson, James G; Razumkov, Hlib; Xiao, Shuke; Spaas, Jan; Fernandez, Daniel; Zhang, Tinghu; Gerszten, Robert E; Benson, Mark D; Gray, Nathanael S; Hinshaw, Stephen M; Long, Jonathan Z; Brahmbhatt, Hemang D; Chavda, Priyank; Vadee, Dhruvinkumar; Patel, Amrutlal K; Bagatharia, Snehal

An AKR1C3-activated kinase inhibitor prodrug.

AKR1C3激活激酶抑制剂前药。

Li Zhengnian, Martinez Michael, Byun Woong Sub, Thathireddy Anuradha, Qiu Tian, Wang Yaning, Katzengruber Leon, Chouldjian Ani, Lu Wenchao, Ji Wenzhi, Che Jianwei, Zhang Tinghu, Hinshaw Stephen M, Gray Nathanael S

A small molecule PTER-selective inhibitor reduces food intake and body weight

一种小分子PTER选择性抑制剂可减少食物摄入量和体重。

Fu, Sipei; Wang, Lushun; Li, Veronica L; Lyu, Xuchao; Wei, Wei; Shi, Xu; Deng, Shuliang; Barber, Jacob L; Tahir, Usman A; Adams, Charleen; Carson, April; Hidalgo, Bertha; Raffield, Laura M; Wilson, James G; Razumkov, Hlib; Xiao, Shuke; Spaas, Jan; Fernandez, Daniel; Zhang, Tinghu; Gerszten, Robert E; Benson, Mark D; Gray, Nathanael S; Hinshaw, Stephen M; Long, Jonathan Z

Overcoming EGFR resistance by monovalent and bident inhibitors targeting Cys775

通过靶向Cys775的单价和双齿抑制剂克服EGFR耐药性

Li, Zhengnian; Jiang, Jie; Wang, Yaning; Ficarro, Scott B; Collins, Stephen J; Beyett, Tyler S; Schaeffner, Ilse K; Tavares, Isidoro; Gottlieb, Felix H; Suda, Dhiraj; Gokhale, Prafulla C; Black-Holmes, Leah M; Gazgalis, Dimitris; Eck, Michael J; Jänne, Pasi A; Marto, Jarrod A; Che, Jianwei; Gray, Nathanael S; Zhang, Tinghu

Design and Development of DNA Damage Chemical Inducers of Proximity (DD-CIP) for Targeted Cancer Therapy.

用于靶向癌症治疗的DNA损伤化学诱导剂邻近诱导剂(DD-CIP)的设计与开发。

Qiu Tian, Lee Yeuan Ting, Dwyer Brendan G, Tan Yi Jer, Chen Ting, Romero Bryan A, Wang Yanlan, Deng Jiehui, Zhang Tinghu, Crabtree Gerald R, Hinshaw Stephen M, Wong Kwok-Kin, Gray Nathanael S

A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death.

将赖氨酸乙酰转移酶与癌基因诱导的细胞死亡联系起来的二价分子胶

Nix Meredith N, Gourisankar Sai, Sarott Roman C, Dwyer Brendan G, Nettles Sabin A, Martinez Michael M, Abuzaid Hind, Yang Haopeng, Wang Yanlan, Simanauskaite Juste M, Romero Bryan A, Jones Hannah M, Krokhotin Andrey, Lowensohn Tara N, Chen Lei, Low Cara, Davis Mark M, Fernandez Daniel, Zhang Tinghu, Green Michael R, Hinshaw Stephen M, Gray Nathanael S, Crabtree Gerald R

Relocalizing transcriptional kinases to activate apoptosis.

重新定位转录激酶以激活细胞凋亡

Sarott Roman C, Gourisankar Sai, Karim Basel, Nettles Sabin, Yang Haopeng, Dwyer Brendan G, Simanauskaite Juste M, Tse Jason, Abuzaid Hind, Krokhotin Andrey, Zhang Tinghu, Hinshaw Stephen M, Green Michael R, Crabtree Gerald R, Gray Nathanael S

Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis.

通过抑制 CDK7 来破坏 RNA 聚合酶 II 转录循环,可以缓解炎症性关节炎

Chen Xi, Shibu Gayathri, Sokolsky Baila A, Soussana Tamar Nicole, Fisher Logan, Deochand Dinesh K, Dacic Marija, Mantel Ian, Ramirez Daniel C, Bell Richard D, Zhang Tinghu, Donlin Laura T, Goodman Susan M, Gray Nathanael S, Chinenov Yurii, Fisher Robert P, Rogatsky Inez

Targeted degradation of oncogenic KRASG12V triggers antitumor immunity in lung cancer models

靶向降解致癌基因KRASG12V可诱导肺癌模型中的抗肿瘤免疫反应

Li, Dezhi; Geng, Ke; Hao, Yuan; Gu, Jiajia; Kumar, Saurav; Olson, Annabel T; Kuismi, Christina C; Kim, Hye Mi; Pan, Yuanwang; Sherman, Fiona; Williams, Asia M; Li, Yiting; Li, Fei; Chen, Ting; Thakurdin, Cassandra; Ranieri, Michela; Meynardie, Mary; Levin, Daniel S; Stephens, Janaye; Chafitz, Alison; Chen, Joy; Donald-Paladino, Mia S; Powell, Jaylen M; Zhang, Ze-Yan; Chen, Wei; Ploszaj, Magdalena; Han, Han; Gu, Shengqing Stan; Zhang, Tinghu; Hu, Baoli; Nacev, Benjamin A; Kaiza, Medard Ernest; Berger, Alice H; Wang, Xuerui; Li, Jing; Sun, Xuejiao; Liu, Yang; Zhang, Xiaoyang; Bruno, Tullia C; Gray, Nathanael S; Nabet, Behnam; Wong, Kwok-Kin; Zhang, Hua