日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Precision medicine for sodium channelopathy-related autism and epilepsy

针对钠通道病相关自闭症和癫痫的精准医疗

Robinson, Morgan; Wettschurack, Kyle; Halurkar, Manasi S; Chen, Xiaoling; Zhang, Zaiyang; Zhang, Jingliang; Yang, Yang

The mechanism of Ningxin-Tongyu-Zishen formula regulating probdnf/mbdnf balance through PAI-1/tPA signaling pathway in the treatment of premature ovarian insufficiency.

宁心通玉紫肾方通过 PAI-1/tPA 信号通路调节 probdnf/mbdnf 平衡治疗卵巢早衰的机制

Ma Jiawen, Zhu Chaofan, Xie Lifang, An Shuaiqi, Zhang Zaiyang, Wang Keying, Zhang Yizhou

Sleep Quality and Premature Ovarian Insufficiency: Genetic Evidence and Clinical Benefits of NTZF Combined with HRT

睡眠质量与卵巢早衰:NTZF联合激素替代疗法的遗传学证据和临床获益

Zhang, Zaiyang; Wang, Keying; An, Shuaiqi; Ma, Jiawen; Zhang, Yizhou

Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of Scn2a -deficient mice

单核转录组学揭示了Scn2a缺陷小鼠前额叶皮层中受损的通路

Yoo, Ye-Eun; Mandal, Purba; Tang, Zhengkuan; Zhang, Zaiyang; Zhang, Jingliang; Chen, Xiaoling; Robinson, Morgan; Eaton, Muriel; Deming, Brody; Halurkar, Manasi; Kothandaraman, Harish; Dabin, Luke C; Jiang, Boyu; Gao, Hongyu; Yuan, Chongli; Lanman, Nadia; Liu, Yunlong; Kim, Jungsu; Baloni, Priyanka; Yang, Yang

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids

癫痫相关的SCN2A-L1342P突变驱动人类皮质类器官网络过度兴奋和广泛的转录组变化

Olivero-Acosta, Maria I; Robinson, Morgan; Que, Zhefu; Zhang, Zaiyang; Harlow, Hope Elizabeth; Shankar, Vinayak; Hong, Seoyong; Wang, Muhan; Otterbacher, Conrad M; Kadono, Hina; Halurkar, Manasi; Kothandaraman, Harish; Lanman, Nadia; Nguyen, Trang; Wettschurack, Kyle; Zirkle, Benjamin; Yunis, Layan; Cui, Ningren; Chen, Xiaoling; Zhang, Jingliang; Wu, Jiaxiang; Skarnes, William C; Yuan, Chongli; Guo, Feng; Yang, Yang

The Pathological Role and Therapeutic potential of ALDH2 in acrolein detoxification Following Spinal Cord Injury in Mice.

ALDH2 在小鼠脊髓损伤后丙烯醛解毒中的病理作用和治疗潜力

Sun Siyuan, Herr Seth, Alford Anna, Stingle Rachel, Zhang Zaiyang, Dong Timothy, Shi Riyi

Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice.

基因疗法可缓解 DBA/2J 小鼠中与 Scn2a 缺陷相关的失神性癫痫

Zhang Zaiyang, Zhang Jingliang, Chen Xiaoling, Deming Brody A, Kant Shivam, Mandal Purba, Kothandaraman Harish, SanMiguel Phillip J, Halurkar Manasi S, Abeyaratna Akila D, Robinson Morgan J, Zhao Yuanrui, Vitko Yuliia, Gaykema Ronald P, Yuan Chongli, Lanman Nadia A, Tegtmeyer Matthew T, Wang Dan, Gao Guangping, Shi Riyi, Perez-Reyes Edward, Yang Yang

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a-deficiency.

恢复兴奋/抑制平衡可提高神经元信噪比,并挽救自闭症相关 Scn2a 缺陷引起的社交缺陷

Zhang Jingliang, Eaton Muriel, Chen Xiaoling, Zhao Yuanrui, Kant Shivam, Deming Brody A, Harish Kothandaraman, Nguyen Huynhvi P, Shu Yue, Lai Shirong, Wu Jiaxiang, Que Zhefu, Wettschurack Kyle W, Zhang Zaiyang, Xiao Tiange, Halurkar Manasi S, Olivero-Acosta Maria I, Yoo Ye-Eun, Lanman Nadia A, Koss Wendy A, Skarnes William C, Yang Yang

Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids.

与自闭症相关的 SCN2A 缺陷会破坏人类大脑组装体中的皮质纹状体回路

Chen Xiaoling, Zhang Jingliang, Wu Jiaxiang, Robinson Morgan J, Kothandaraman Harish, Yoo Ye-Eun, Dopeso-Reyes Iria M Gonzalez, Buffenoir Thomas D, Halurkar Manasi S, Zhang Zaiyang, Wang Muhan, Creager Erin N, Zhao Yuanrui, Olivero-Acosta Maria I, Wettschurack Kyle W, Que Zhefu, Yuan Chongli, Schaser Allison J, Lanman Nadia A, Rochet Jean-Christophe, Skarnes William C, Kremer Eric J, Yang Yang

Temporal differential effects of post-injury alcohol consumption in a mouse model of blast-induced traumatic brain injury

爆炸诱发创伤性脑损伤小鼠模型中,损伤后饮酒的时间差异性影响

Zhang, Zaiyang; Xiao, Tiange; Hall, Mekyna R; Crodian, Jennifer S; Alford, Anna K; Kimbrough, Adam; Shi, Riyi