日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A cytokine receptor-targeting chimera toolbox for expanding extracellular targeted protein degradation.

用于扩展细胞外靶向蛋白降解的细胞因子受体靶向嵌合体工具箱。

Kumru Kaan, Yao Zi, Holmes Brandon B, Zhao Fangzhu, Zhang Yun, Ferrara Emilio, Peters-Clarke Trenton M, Leung Kevin K, Wells James A

Targeted shedding of extracellular membrane proteins by induced protease recruitment

通过诱导蛋白酶募集靶向脱落细胞外膜蛋白

Yao, Zi; Zhao, Fangzhu; Miao, Kun; Peters-Clarke, Trenton M; Zhang, Yun; Ganjave, Snehal D; Vázquez-Maldonado, Angel L; Wu, Yan; Kumru, Kaan; Jumaa, Hammam; Leung, Kevin K; Wells, James A

Directed evolution of a stem-helix-targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity.

通过定向进化,靶向茎螺旋结构的抗体能够增强结合亲和力,从而实现对MERS-CoV的交叉中和。

Zhou Panpan, Yuan Meng, Zhang Yuexiu, Limbo Oliver, Song Ge, Zhao Fangzhu, Liu Hejun, He Wan-Ting, Capozzola Tazio, Callaghan Sean, Avillion Gabriel, Li Xuduo, Beutler Nathan, Yong Peter, Anzanello Fabio, Rogers Thomas F, Burton Dennis R, Jardine Joseph G, Wilson Ian A, Andrabi Raiees

A cytokine receptor-targeting chimera (kineTAC) toolbox for expanding extracellular targeted protein degradation.

用于扩展细胞外靶向蛋白降解的细胞因子受体靶向嵌合体(kineTAC)工具箱

Kumru Kaan, Yao Zi, Holmes Brandon B, Zhao Fangzhu, Zhang Yun, Ferrara Emilio, Peters-Clarke Trenton M, Leung Kevin K, Wells James A

Low-density lipoprotein receptor-targeting chimeras for membrane protein degradation and enhanced drug delivery.

低密度脂蛋白受体靶向嵌合体用于膜蛋白降解和增强药物递送

Zhao Fangzhu, Wu Yan, Schaefer Kaitlin, Zhang Yun, Miao Kun, Yao Zi, Ganjave Snehal D, Kumru Kaan, Peters-Clarke Trenton M, Inague Alex, Olzmann James A, Leung Kevin K, Wells James A

Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins

用于快速生成四价双特异性纳米抗体免疫球蛋白的全合成平台

Misson Mindrebo, Laetitia; Liu, Hejun; Ozorowski, Gabriel; Tran, Quoc; Woehl, Jordan; Khalek, Irene; Smith, Jessica M; Barman, Shawn; Zhao, Fangzhu; Keating, Celina; Limbo, Oliver; Verma, Megan; Liu, Jingjia; Stanfield, Robyn L; Zhu, Xueyong; Turner, Hannah L; Sok, Devin; Huang, Po-Ssu; Burton, Dennis R; Ward, Andrew B; Wilson, Ian A; Jardine, Joseph G

A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection

多种交叉中和抗体联合使用可协同预防SARS-CoV-2和SARS-CoV假病毒感染。

Liu, Hejun; Yuan, Meng; Huang, Deli; Bangaru, Sandhya; Zhao, Fangzhu; Lee, Chang-Chun D; Peng, Linghang; Barman, Shawn; Zhu, Xueyong; Nemazee, David; Burton, Dennis R; van Gils, Marit J; Sanders, Rogier W; Kornau, Hans-Christian; Reincke, S Momsen; Prüss, Harald; Kreye, Jakob; Wu, Nicholas C; Ward, Andrew B; Wilson, Ian A

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

分离出有效的SARS-CoV-2中和抗体,并在小型动物模型中提供疾病保护

Rogers, Thomas F; Zhao, Fangzhu; Huang, Deli; Beutler, Nathan; Burns, Alison; He, Wan-Ting; Limbo, Oliver; Smith, Chloe; Song, Ge; Woehl, Jordan; Yang, Linlin; Abbott, Robert K; Callaghan, Sean; Garcia, Elijah; Hurtado, Jonathan; Parren, Mara; Peng, Linghang; Ramirez, Sydney; Ricketts, James; Ricciardi, Michael J; Rawlings, Stephen A; Wu, Nicholas C; Yuan, Meng; Smith, Davey M; Nemazee, David; Teijaro, John R; Voss, James E; Wilson, Ian A; Andrabi, Raiees; Briney, Bryan; Landais, Elise; Sok, Devin; Jardine, Joseph G; Burton, Dennis R

Structural basis of a shared antibody response to SARS-CoV-2

SARS-CoV-2 共同抗体反应的结构基础

Yuan, Meng; Liu, Hejun; Wu, Nicholas C; Lee, Chang-Chun D; Zhu, Xueyong; Zhao, Fangzhu; Huang, Deli; Yu, Wenli; Hua, Yuanzi; Tien, Henry; Rogers, Thomas F; Landais, Elise; Sok, Devin; Jardine, Joseph G; Burton, Dennis R; Wilson, Ian A

Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

快速分离强效SARS-CoV-2中和抗体并在小型动物模型中提供保护

Rogers, Thomas F; Zhao, Fangzhu; Huang, Deli; Beutler, Nathan; Burns, Alison; He, Wan-Ting; Limbo, Oliver; Smith, Chloe; Song, Ge; Woehl, Jordan; Yang, Linlin; Abbott, Robert K; Callaghan, Sean; Garcia, Elijah; Hurtado, Jonathan; Parren, Mara; Peng, Linghang; Ricketts, James; Ricciardi, Michael J; Rawlings, Stephen A; Smith, Davey M; Nemazee, David; Teijaro, John R; Voss, James E; Andrabi, Raiees; Briney, Bryan; Landais, Elise; Sok, Devin; Jardine, Joseph G; Burton, Dennis R