日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transient acute neuronal activation response caused by high concentrations of oligonucleotides in the cerebral spinal fluid

脑脊液中高浓度寡核苷酸引起的短暂急性神经元激活反应

Bravo-Hernandez, Mariana; Mazur, Curt; Chen, Hao; Fradkin, Linda; Searcy, Justin; Burel, Sebastien; Kelly, Mackenzie; Bruening, Dona; O'Rourke, Jacqueline G; Cai, Yuhang; Nguyen, Jonathon; Berman-Booty, Lisa; Cummins, Lendell; Gaus, Hans; Powers, Berit; Zhao, Hien T; Jafar-Nejad, Paymaan; Henry, Scott; Swayze, Eric E; Kordasiewicz, Holly B

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

脊髓中的翻译调控机制调节神经性疼痛慢性期的基因表达和疼痛过敏。

Lister, Kevin C; Wong, Calvin; Uttam, Sonali; Parisien, Marc; Stecum, Patricia; Brown, Nicole; Cai, Weihua; Ho-Tieng, David; Hooshmandi, Mehdi; Gu, Ning; Amiri, Mehdi; Beaudry, Francis; Jafarnejad, Seyed Mehdi; Tavares-Ferreira, Diana; Inturi, Nikhil Nageshwar; Mazhar, Khadijah; Zhao, Hien T; Fitzsimmons, Bethany; Gkogkas, Christos G; Sonenberg, Nahum; Price, Theodore J; Diatchenko, Luda; Atlasi, Yaser; Mogil, Jeffrey S; Khoutorsky, Arkady

Atrophin-1 antisense oligonucleotide provides robust protection from pathology in a fully humanized DRPLA model.

Atrophin-1 反义寡核苷酸在完全人源化的 DRPLA 模型中提供了强大的病理保护作用。

Smith Velvet L, Gidi Bereket Z, Bragg Robert M, Cantle Jeffrey P, Ben-Varon Aliza, Noble Briana, Prades Silvia, Compton Andrea, Greenfield Julie, Korecka Joanna A, Gemos Anya, Yu Timothy, Khurana Vikram, Kordasiewicz Holly B, Zhao Hien T, Barker-Haliski Melissa, Child Daniel D, Carroll Jeffrey B

Peripherally administered androgen receptor-targeted antisense oligonucleotide rescues spinal pathology in a murine SBMA model.

外周给药的靶向雄激素受体的反义寡核苷酸可挽救小鼠脊髓延髓肌萎缩症模型中的脊髓病理。

Lee Changwoo, Yu Zhigang, Kuo Curtis J, Tejwani Leon, Grijalva Rosalie M, Bae Eunwoo, Zhao Hien T, Lim Janghoo, Lieberman Andrew P

Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome.

针对 App 和 Rab5Â 的反义寡核苷酸可使内体 Rab 活性正常化,并逆转唐氏综合征 Dp16 小鼠模型中与 DS-AD 相关的退行性表型

Chen Xu-Qiao, Zuo Xinxin, Becker Ann, Mante Michael, Florio Jazmin B, Jadhav Satish G, Albay Ricardo, Johnstone Aaron, Karachentsev Dmitry, Rissman Robert, Zhao Hien, Dowdy Steven F, Mobley William C

SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides.

SARM1 激活可导致可逆性线粒体功能障碍,而反义寡核苷酸可以预防人类神经元中的这种功能障碍

Loreto Andrea, Cramb Kaitlyn M L, McDermott Lucy A, Antoniou Christina, Cirilli Ilenia, Caiazza Maria Claudia, Merlini Elisa, Arthur-Farraj Peter, du Preez W Daniel, Mock Elliot D, Zhao Hien T, Bennett David L, Orsomando Giuseppe, Coleman Michael P, Wade-Martins Richard

A single-cell map of antisense oligonucleotide activity in the brain

大脑中反义寡核苷酸活性的单细胞图谱

Mortberg, Meredith A; Gentile, Juliana E; Nadaf, Naeem; Vanderburg, Charles; Simmons, Sean; Dubinsky, Dan; Slamin, Adam; Maldonado, Salome; Petersen, Caroline L; Jones, Nichole; Kordasiewicz, Holly B; Zhao, Hien T; Vallabh, Sonia M; Minikel, Eric Vallabh

Intratumoral γδ T-Cell Infiltrates, Chemokine (C-C Motif) Ligand 4/Chemokine (C-C Motif) Ligand 5 Protein Expression and Survival in Patients With Hepatocellular Carcinoma

肝细胞癌患者肿瘤内 γδ T 细胞浸润、趋化因子(CC 基序)配体 4/趋化因子(CC 基序)配体 5 蛋白表达和生存率

Na Zhao, Hien Dang, Lichun Ma, Sean P Martin, Marshonna Forgues, Kris Ylaya, Stephen M Hewitt, Xin Wei Wang

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

降低朊病毒蛋白水平是一种能够改善朊病毒疾病各个阶段、毒株和终点的疾病治疗手段。

Minikel, Eric Vallabh; Zhao, Hien T; Le, Jason; O'Moore, Jill; Pitstick, Rose; Graffam, Samantha; Carlson, George A; Kavanaugh, Michael P; Kriz, Jasna; Kim, Jae Beom; Ma, Jiyan; Wille, Holger; Aiken, Judd; McKenzie, Deborah; Doh-Ura, Katsumi; Beck, Matthew; O'Keefe, Rhonda; Stathopoulos, Jacquelyn; Caron, Tyler; Schreiber, Stuart L; Carroll, Jeffrey B; Kordasiewicz, Holly B; Cabin, Deborah E; Vallabh, Sonia M

PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent models

PMP22 反义寡核苷酸可逆转啮齿动物模型中 Charcot-Marie-Tooth 病 1A 型的特征

Zhao, Hien Tran; Damle, Sagar; Ikeda-Lee, Karli; Kuntz, Steven; Li, Jian; Mohan, Apoorva; Kim, Aneeza; Hung, Gene; Scheideler, Mark A; Scherer, Steven S; Svaren, John; Swayze, Eric E; Kordasiewicz, Holly B