文献库，生知库 | 链接生命科学的每一步

RNA inosine sensor-guided TadA mutational scanning for toxicity minimization of adenine base editors.

RNA肌苷传感器引导的TadA突变扫描用于最大限度地降低腺嘌呤碱基编辑器的毒性。

doi:10.1016/j.ymthe.2025.10.011

Zhang Cheng, Chen Ziliang, Cao Jixin, Zhang Zui, Li Wei-Ke, Zhang Xinyi, Chen Junying, Liu Jun, Yuan Zhou, Gao Feng, Shi Zehao, Zhao Xing-Ming, Chen Jingqi, Zhan Changyou, Cheng Tian-Lin

Identification of plasma biomarkers in lipid metabolism for accurate prediction of Alzheimer's disease

鉴定血浆脂质代谢生物标志物以准确预测阿尔茨海默病

期刊:Translational Psychiatry

影响因子:6.2

doi:10.1038/s41398-026-03933-7

Luo, Xiaohui; Jia, Longhao; Cao, Jixin; Guo, Qihao; Chen, Jingqi; Zhao, Xing-Ming

18 Impact of nutritional management strategies on the gastrointestinal development, barrier function and metabolism of the calf and cow

18 营养管理策略对犊牛和母牛胃肠道发育、屏障功能和代谢的影响

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202305818

Chen, Jingchao; Sun, Chuqing; Dong, Yanqi; Jin, Menglu; Lai, Senying; Jia, Longhao; Zhao, Xueyang; Wang, Huarui; Gao, Na L; Bork, Peer; Liu, Zhi; Chen, Wei-Hua; Zhao, Xing-Ming; Steele, Michael A

Integrating rare pathogenic variant prioritization with gene-based association analysis to identify novel genes and relevant multimodal traits for Alzheimer's disease

将罕见致病变异优先排序与基于基因的关联分析相结合，以识别阿尔茨海默病的新基因和相关多模态特征。

期刊:Alzheimers & Dementia

影响因子:11.1

doi:10.1002/alz.14444

Cao, Jixin; Zhang, Cheng; Lo, Chun-Yi Zac; Guo, Qihao; Ding, Jing; Luo, Xiaohui; Zhang, Zi-Chao; Chen, Feng; Cheng, Tian-Lin; Chen, Jingqi; Zhao, Xing-Ming

阿尔茨海默症

发表日期：2025

文献求助收藏

HGMT: a database of human gut microbiota for tumors and immunotherapy response

HGMT：一个用于研究肿瘤和免疫疗法反应的人类肠道菌群数据库

期刊:Genome Biology

影响因子:9.4

doi:10.1186/s13059-025-03865-3

Liu, Jinxin; Wang, Mingyu; Xu, Chentao; Jia, Longhao; Lai, Senying; Zhang, Zi-Chao; Zhang, Jinglong; Chen, Wei-Hua; Yang, Yucheng T; Zhao, Xing-Ming

Regulatory Genomic Circuitry of Brain Age by Integrative Functional Genomic Analyses

通过整合功能基因组分析揭示大脑年龄的调控基因组回路

期刊:Genomics Proteomics & Bioinformatics

影响因子:7.9

doi:10.1093/gpbjnl/qzaf064

Zhao, Xingzhong; Yang, Anyi; Ding, Jing; Yang, Yucheng T; Zhao, Xing-Ming

Biases and complementarity in gut viromes obtained from bulk and virus-like particle-enriched metagenomic sequencing

从大量和病毒样颗粒富集的宏基因组测序中获得的肠道病毒组的偏倚和互补性

期刊:Microbiology Spectrum

影响因子:3.8

doi:10.1128/spectrum.00013-25

Li, Yun; Sun, Chuqing; Zhu, Jiaying; Geng, Mingyan; Li, Min; Zhao, Xing-Ming; Chen, Wei-Hua

微生物学

发表日期：2025

文献求助收藏

Discovery of antimicrobial peptides in the global microbiome with machine learning.

利用机器学习技术在全球微生物组中发现抗菌肽

期刊:Cell

影响因子:42.5

doi:10.1016/j.cell.2024.05.013

Santos-JÃºnior CÃ©lio Dias, Torres Marcelo D T, Duan Yiqian, RodrÃguez Del RÃo Ãlvaro, Schmidt Thomas S B, Chong Hui, Fullam Anthony, Kuhn Michael, Zhu Chengkai, Houseman Amy, Somborski Jelena, Vines Anna, Zhao Xing-Ming, Bork Peer, Huerta-Cepas Jaime, de la Fuente-Nunez Cesar, Coelho Luis Pedro

Compared to histamine-2 receptor antagonist, proton pump inhibitor induces stronger oral-to-gut microbial transmission and gut microbiome alterations: a randomised controlled trial

与组胺-2受体拮抗剂相比，质子泵抑制剂能诱导更强的口腔到肠道微生物传播和肠道微生物群改变：一项随机对照试验

期刊:Gut

影响因子:25.8

doi:10.1136/gutjnl-2023-330168

Zhu, Jiaying; Sun, Chuqing; Li, Min; Hu, Guoru; Zhao, Xing-Ming; Chen, Wei-Hua

Impacts of host genetics on gut microbiome composition in Alzheimer's disease

宿主遗传因素对阿尔茨海默病患者肠道微生物群组成的影响

RNA inosine sensor-guided TadA mutational scanning for toxicity minimization of adenine base editors.

RNA肌苷传感器引导的TadA突变扫描用于最大限度地降低腺嘌呤碱基编辑器的毒性。

Identification of plasma biomarkers in lipid metabolism for accurate prediction of Alzheimer's disease

鉴定血浆脂质代谢生物标志物以准确预测阿尔茨海默病

18 Impact of nutritional management strategies on the gastrointestinal development, barrier function and metabolism of the calf and cow

18 营养管理策略对犊牛和母牛胃肠道发育、屏障功能和代谢的影响

Integrating rare pathogenic variant prioritization with gene-based association analysis to identify novel genes and relevant multimodal traits for Alzheimer's disease

将罕见致病变异优先排序与基于基因的关联分析相结合，以识别阿尔茨海默病的新基因和相关多模态特征。

HGMT: a database of human gut microbiota for tumors and immunotherapy response

HGMT：一个用于研究肿瘤和免疫疗法反应的人类肠道菌群数据库

Regulatory Genomic Circuitry of Brain Age by Integrative Functional Genomic Analyses

通过整合功能基因组分析揭示大脑年龄的调控基因组回路

Biases and complementarity in gut viromes obtained from bulk and virus-like particle-enriched metagenomic sequencing

从大量和病毒样颗粒富集的宏基因组测序中获得的肠道病毒组的偏倚和互补性

Discovery of antimicrobial peptides in the global microbiome with machine learning.

利用机器学习技术在全球微生物组中发现抗菌肽

Compared to histamine-2 receptor antagonist, proton pump inhibitor induces stronger oral-to-gut microbial transmission and gut microbiome alterations: a randomised controlled trial

与组胺-2受体拮抗剂相比，质子泵抑制剂能诱导更强的口腔到肠道微生物传播和肠道微生物群改变：一项随机对照试验