Zhen Xuechu相关文献与解析，生知库 | 链接生命科学的每一步

Discovery and proof-of-concept study of a novel highly selective sigma-1 receptor agonist for antipsychotic drug development

发现并开展概念验证研究，探索一种新型高选择性σ-1受体激动剂在抗精神病药物开发中的应用

doi:10.1016/j.apsb.2025.04.028

Tang, Wanyu; Ma, Zhixue; Li, Bang; Yu, Zhexiang; Zhao, Xiaobao; Yang, Huicui; Hu, Jian; Tian, Sheng; Gu, Linghan; Chen, Jiaojiao; Zou, Xing; Wang, Qi; Chen, Fan; Li, Guangying; Zheng, Chaonan; Gao, Shuliu; Liu, Wenjing; Li, Yue; Zheng, Wenhua; Wang, Mingmei; Ye, Na; Zhen, Xuechu

信号转导

发表日期：2025

文献求助收藏

Macrophage migration inhibitory factor (MIF) in CNS diseases: Functional regulation and potential therapeutic indication

巨噬细胞迁移抑制因子（MIF）在中枢神经系统疾病中的作用：功能调控及潜在治疗意义

期刊:Fundamental Research

影响因子:6.3

doi:10.1016/j.fmre.2023.05.008

Zhang, Yu; Yu, Zhexiang; Ye, Na; Zhen, Xuechu

'Whole-Body' Perspectives of Schizophrenia and Related Psychotic Illness: miRNA-143 as an Exemplary Molecule Implicated across Multi-System Dysfunctions

精神分裂症及相关精神病性疾病的“全身”视角：miRNA-143作为一种与多系统功能障碍相关的典型分子

期刊:Biomolecules

影响因子:4.8

doi:10.3390/biom14091185

Waddington, John L; Wang, Xiaoyu; Zhen, Xuechu

Development and Evaluation of Novel Metformin Derivative Metformin Threonate for Brain Ischemia Treatment

新型二甲双胍衍生物苏糖酸二甲双胍治疗脑缺血的研发与评价

期刊:Frontiers in Pharmacology

影响因子:4.8

doi:10.3389/fphar.2022.879690

Zhang, Gufang; Chen, Shuangshuang; Jia, Jia; Liu, Chun; Wang, Weipeng; Zhang, Hongjian; Zhen, Xuechu

神经科学

发表日期：2022

文献求助收藏

Developmental Genes and Regulatory Proteins, Domains of Cognitive Impairment in Schizophrenia Spectrum Psychosis and Implications for Antipsychotic Drug Discovery: The Example of Dysbindin-1 Isoforms and Beyond

发育基因和调控蛋白、精神分裂症谱系精神病认知障碍的领域及其对抗精神病药物研发的启示：以Dysbindin-1亚型为例及其他

期刊:Frontiers in Pharmacology

影响因子:4.8

doi:10.3389/fphar.2019.01638

Waddington, John L; Zhen, Xuechu; O'Tuathaigh, Colm M P

miRNA-3473b contributes to neuroinflammation following cerebral ischemia

miRNA-3473b 促进脑缺血后的神经炎症

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-017-0014-7

Wang, Xiaoyu; Chen, Shuangshuang; Ni, Jingshu; Cheng, Jian; Jia, Jia; Zhen, Xuechu

Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases

Sigma-1受体调控的神经系统疾病中的神经炎症

期刊:Frontiers in Cellular Neuroscience

影响因子:4

doi:10.3389/fncel.2018.00314

Jia, Jia; Cheng, Jian; Wang, Cheng; Zhen, Xuechu

Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies

将精神分裂症分子基础研究的最新进展转化为新的认知治疗策略

期刊:British Journal of Pharmacology

影响因子:7.7

doi:10.1111/bph.13938

O'Tuathaigh, Colm M P; Moran, Paula M; Zhen, Xuechu C; Waddington, John L

Allosteric modulation of sigma-1 receptors elicits anti-seizure activities

σ-1受体的变构调节可产生抗癫痫活性

期刊:British Journal of Pharmacology

影响因子:7.7

doi:10.1111/bph.13195

Guo, Lin; Chen, Yanke; Zhao, Rui; Wang, Guanghui; Friedman, Eitan; Zhang, Ao; Zhen, Xuechu

Endosome-phagophore linking assemblies for the degradation of membrane/extracellular proteins

内体-吞噬泡连接组装体用于降解膜蛋白/细胞外蛋白

Discovery and proof-of-concept study of a novel highly selective sigma-1 receptor agonist for antipsychotic drug development

发现并开展概念验证研究，探索一种新型高选择性σ-1受体激动剂在抗精神病药物开发中的应用

Macrophage migration inhibitory factor (MIF) in CNS diseases: Functional regulation and potential therapeutic indication

巨噬细胞迁移抑制因子（MIF）在中枢神经系统疾病中的作用：功能调控及潜在治疗意义

'Whole-Body' Perspectives of Schizophrenia and Related Psychotic Illness: miRNA-143 as an Exemplary Molecule Implicated across Multi-System Dysfunctions

精神分裂症及相关精神病性疾病的“全身”视角：miRNA-143作为一种与多系统功能障碍相关的典型分子

Development and Evaluation of Novel Metformin Derivative Metformin Threonate for Brain Ischemia Treatment

新型二甲双胍衍生物苏糖酸二甲双胍治疗脑缺血的研发与评价

Developmental Genes and Regulatory Proteins, Domains of Cognitive Impairment in Schizophrenia Spectrum Psychosis and Implications for Antipsychotic Drug Discovery: The Example of Dysbindin-1 Isoforms and Beyond

发育基因和调控蛋白、精神分裂症谱系精神病认知障碍的领域及其对抗精神病药物研发的启示：以Dysbindin-1亚型为例及其他

miRNA-3473b contributes to neuroinflammation following cerebral ischemia

miRNA-3473b 促进脑缺血后的神经炎症

Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases

Sigma-1受体调控的神经系统疾病中的神经炎症

Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies

将精神分裂症分子基础研究的最新进展转化为新的认知治疗策略

Allosteric modulation of sigma-1 receptors elicits anti-seizure activities

σ-1受体的变构调节可产生抗癫痫活性