日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PIKfyve inhibition in MM disrupts autophagy and lysosome function, increasing MHC expression and cholesterol metabolism.

PIKfyve 在 MM 中受到抑制会破坏自噬和溶酶体功能,增加 MHC 表达和胆固醇代谢。

Bonolo de Campos Cecilia, He Ruijuan, Pelino Tessa, Abelman Dor D, Li Zhihua, Lee Daniel K C, Wang Ding Yan, St Paul Michael, Bruce Jeffrey, Simpson Craig D, Wybeng-Groot Leanne, Moran Michael F, Tiedemann Rodger, Pugh Trevor, Mak Tak W, Issakova Olga, Sepetov Nikolai, Trudel Suzanne, Stewart A Keith

Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancer.

靶向从头嘧啶合成会使 PARP 抑制剂耐药的卵巢癌对铜介导的 ATR 失活变得脆弱。

Nan Yabing, Wang Kunyu, Hu Menghan, Luo Qingyu, Wu Xiaowei, Yu Xiao, Zhou Xuantong, Chen Li, Li Bin, Cui Zhumei, Liu Zhihua

IgG-Bridging-Seeded Synergistic Aggregation of SARS-CoV-2 Spikes Underlies Potent Neutralization by a Low-Affinity Antibody.

SARS-CoV-2 刺突蛋白的 IgG 桥接种子协同聚集是低亲和力抗体有效中和的基础。

Lv Niannian, Chen Peng, Dai Xiaobin, Xu Hu, Li Ziheng, Shan Zelin, Li Jinqian, Guo Fenglin, Chen Yuanfang, Li Jiayi, Huang Yiqian, Dong Guizhi, Jiang Yifan, Chen Liang, Nan Xuanyu, Zhao Hanjun, Zhang Kang, Fan Shilong, Dong Yuanchen, Liu Dongsheng, Wang Xinquan, Huang Deli, Pan Xiaojing, Chen Chunying, Liu Zhihua, Yan Li-Tang, Zhang Qi, Zhang Linqi, Zhao Yuliang, Yang Yuhe Renee

PARP inhibitors restore NK cell function via secretory crosstalk with tumor cells in prostate cancer

PARP抑制剂通过与前列腺癌肿瘤细胞的分泌性串扰恢复NK细胞功能

Chao, Zheng; Li, Le; Hao, Xiaodong; Peng, Hao; Wang, Yanan; Zhang, Chunyu; Guo, Xiangdong; Liu, Peikun; Ma, Sheng; Zhang, Junbiao; Qu, Guanyu; Peng, Yuzheng; Wei, Zhengping; Luo, Jing; Liu, Bo; Lan, Peixiang; Wang, Zhihua

Lactylation-driven NSUN2-mediated RNA m5C modification promotes perineural invasion in pancreatic cancer.

乳酸化驱动的 NSUN2 介导的 RNA m5C 修饰促进胰腺癌的神经周围侵袭。

Huang Tianhao, Hu Chonghui, Chen Huimou, Jiang Honghui, Li Tingting, Tian Qing, He Rihua, Yuan Yuan, Jiang Yong, Zhou Yu, Lin Qing, Li Zhihua, Xiao Mingming, Wei Xuebiao, Chen Rufu, Zheng Shangyou

Fitness Training for γδ T cells in mouse and human atherosclerosis takes place in plaques and artery tertiary lymphoid organs.

小鼠和人类动脉粥样硬化中 α3α T 细胞的适应性训练发生在斑块和动脉三级淋巴器官中。

Wang Zhihua, Sun Ting, Zhang Yixin, Li Yutao, Zhang Chuankai, Dou Xinwen, Deng Xinyi, Li Zhipeng, Zhu Jingpu, Hong Mingyang, Ran Yi, Wang Shu, Li Liping, Zheng Junjie, Wen Cong, Zhang Xi, Lu Shu, Sagar, Mohanta Sarajo K, Habenicht Andreas J R, Yin Changjun

Anti-TIM-3 antibody TQB2618 in combination with penpulimab in relapsed or refractory classic Hodgkin lymphoma previously treated with PD-1/PD-L1 therapy: a multicenter, open-label, single-arm, phase Ib clinical trial

抗TIM-3抗体TQB2618联合penpulimab治疗既往接受过PD-1/PD-L1靶向治疗的复发或难治性经典霍奇金淋巴瘤:一项多中心、开放标签、单臂Ib期临床试验

Hong, Huangming; Chen, Zegeng; Cui, Jie; Zhang, Qingyuan; Li, Ping; Tao, Rong; Huang, He; Wang, Binghua; Li, Wuping; Wu, Hui; Wei, Jin; Su, Liping; Zhang, Zhihua; Zhong, Mingxing; Wang, Huaqing; Wang, Cong; Zhou, Hui; Wang, Jishi; Dong, Min; Lin, Tongyu

Targeting SPP1 (+)TAMs associated with liver metastasis reverses immunosuppression and synergizes with immunotherapy in colorectal cancer.

靶向与肝转移相关的 SPP1 (+)TAMs 可逆转免疫抑制,并与结直肠癌的免疫疗法产生协同作用。

Lin Yilin, Chen Zhihua, Zhao Shidong, Zhao Long, Yang Changjiang, Zhu Mingxuan, Ye Yingjiang, Wang Shan, Shen Zhanlong

OTUD4 deubiquitination stabilizes EGFR and activates the PI3K/AKT pathway to promote the invasiveness of triple-negative breast cancer.

OTUD4 去泛素化可稳定 EGFR 并激活 PI3K/AKT 通路,从而促进三阴性乳腺癌的侵袭性。

Ren Yu, Zhou Fulin, Tan Zhihua, Yang Senguo, Zhang Shaolin, Zhang Yonglin, Fu Yumei, Zhang Mai, Liu Shu

Intranasal Naloxone Reversal of Opioid-induced Respiratory Depression in Opioid-naive Individuals and Self-reported Daily Opioid Users

鼻内纳洛酮逆转阿片类药物引起的呼吸抑制,适用于未使用过阿片类药物的个体和自述每日使用阿片类药物的个体。

van Lemmen, Maarten A; Florian, Jeffry; Li, Zhihua; van Velzen, Monique; Olofsen, Erik; Dahan, Albert; Niesters, Marieke; Sarton, Elise; van der Schrier, Rutger