日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Oncolytic virus M1 reinvigorates CD8(+) T-cell immunity against glioblastoma through B-cell-dependent antigen cross-presentation in the spleen.

溶瘤病毒 M1 通过脾脏中 B 细胞依赖性抗原交叉呈递,重新激活 CD8(+) T 细胞对胶质母细胞瘤的免疫力。

Han Yu, Guo Cui, Chen Chaoxin, Yang Wenzhuo, Li Honghui, He Changjia, Deng Jialin, Chen Zhijie, Liu Wenfeng, Chen Jiehong, Zhong Yingqian, Yan Caixin, Xu Cuiying, Liang Xuanming, Zhong Sheng, Chen Furong, Li Depei, Li Cong, Hu Wanming, Chen Zhenghe, Mou Yonggao, Chen Zhongping, Yan Guangmei, Lim Michael, Zhu Wenbo, Sai Ke

MerTK-triggered TGFβ1 autocrine signal regulates microglial response to neurodegeneration.

MerTK触发的TGFβ1自分泌信号调节小胶质细胞对神经退行性疾病的反应。

Huang Yingying, Deng Zhangyuzi, Zhou Zhijie, Fu Koukou, Liu Fuhai, Zhang Haoyue, Chen Jian, Yang Jing, Cao Ying

CRISPR/Cas9 screening with destabilized bicistronic fluorescent protein reporter revealed PABPN1 as a hub of regulators for alternative polyadenylation.

利用不稳定的双顺反子荧光蛋白报告基因进行 CRISPR/Cas9 筛选,发现 PABPN1 是替代多聚腺苷酸化的调节中心。

Hu Zhijie, Liu Yuchi, Han Yuting, Li Mengxia, Deng Ke, Lu Xin, Huang Yingye, Liang Cheng, Wang Yonghua, Fu Yonggui, Xu Anlong

Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheimer's disease via cGAS-STING inhibition

带有锁状结构的六螺旋DNA束介导的siSTING递送通过抑制cGAS-STING改善阿尔茨海默病

Zhang, Manqing; Lan, Yufei; Yue, Qu; He, Jinjun; Li, Lei; Zhang, Huan; Dong, Yaoyuan; Wang, Yuankai; Lu, Jiankun; Lu, Zhijie; Hao, Feiyunduo; Chen, Sui; Jiang, Yixiao; Zhang, Chao; Zhao, Yan; Guo, Hongbo

Telomere-to-telomere genome assembly and comprehensive mutation library facilitate bitter gourd breeding and functional genomics research

端粒到端粒的基因组组装和全面的突变库有助于苦瓜育种和功能基因组学研究。

Zhang, Yilin; Wang, Xiaoyi; Wang, Yan; Niu, Yu; Han, Xu; Tan, Jingsheng; Ma, Xinyu; Zhang, Qingzheng; Liu, Jie; Zhang, Zhijie; Gao, Wenying; Liang, Wenjie; Li, Luyao; Liu, ZhaoHua; Zhang, Xingping; He, Hang; Yang, Yan; Yu, Renbo

Ipriflavone From Aquilaria malaccensis Lam. Exosome-Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia-Inducible Factor-α (HIF-α) Hydroxylation Thereby Alleviating Hypoxia-Induced Gastrointestinal Mucosal Ferroptosis.

来自沉香属植物沉香的异丙黄酮外泌体样纳米颗粒靶向脯氨酰羟化酶结构域蛋白 2 (PHD2) 以增强缺氧诱导因子-α (HIF-α) 羟基化,从而缓解缺氧诱导的胃肠道粘膜铁死亡。

Wang Dezhi, Liao Xingchen, Wang Yilin, Wang Xuexin, Zhang Heng, Zeng Jie, Zhang Mingjie, Wang Xin, Ren Fangli, Wang Yinyin, Li Meng, Wang Wenchen, Lin Qing, Gu Lingyun, Chang Zhijie, Sheng Jianqiu

ROS-responsive, brain- and M1 microglia-targeting modified ginkgetin-loaded smart liposomes ameliorate cerebral ischemia by HIF-1α-mediated negative regulation of microglia pyroptosis.

ROS 响应性、靶向脑和 M1 小胶质细胞的修饰银杏黄素负载智能脂质体通过 HIF-1α 介导的小胶质细胞焦亡的负调控来改善脑缺血。

Li Xueyuan, Ye Zi, Nie Wenyang, Zhou Bao, Qin Haocheng, Zhao Zhijie, Fu Yilong, Liu Dun, Zheng Shaowei, Wang Liangyu, Ma Jun, Guo Jingying, Nie Beibei, Lu Yan, Yan Dongming, Luo Zhiwen, Wang Qingshan, Bian Meng, Jiang Hui, Chen Di

High-altitude hypoxia drives dentate gyrus neuronal vulnerability through an IL1α-astrocyte-SLC1A2 pathway.

高海拔缺氧通过 IL1α-星形胶质细胞-SLC1A2 通路驱动齿状回神经元的脆弱性。

Zhang Yunan, Ni Zhexin, Xia Tiantian, Zhang Nan, Shen Pan, Wang Ningning, Bai Zhijie, Ma Yaolei, Wang Rui, Sun Dezhi, Li Shuman, Huangfu Chaoji, Gao Yue, Zhou Wei

Targeting Macrophage-to-Myofibroblast Transition Mitigates Progression from Inflammation to Fibrosis in Rosacea.

靶向巨噬细胞向肌成纤维细胞的转变可减轻玫瑰痤疮从炎症到纤维化的进展。

Chen Chengqian, Wang Peiru, Cao Yajing, Sung Dongbin, Yang Yutong, Yang Jin, Liu Jia, Yan Yu, Ruan Zhijie, Dong Jie, Yan Jia, Chang Qihang, Li Chunying, Liu Xiaojing, Wang Xiuli, Zeng Qingyu

ZCCHC4 Orchestrates Hepatocellular Carcinoma Metastasis by Regulating Lipid biosynthesis and TMEM97/LCN2/Twist1 Pathway.

ZCCHC4 通过调节脂质生物合成和 TMEM97/LCN2/Twist1 通路来调控肝细胞癌转移。

Ye Juan, Wen Xinyi, Liu Ruiyang, Huang Caini, Xu Zhijie, Zhan Yi, Xu Fuyuan, Huang Hongbin, Qi Chunhui, Tang Yao, Li Peirong, He Jianzhong, Zhao Zhiju, Lu Gang, Xiao Fei