日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A dual diffusion model enables 3D molecule generation and lead optimization based on target pockets

双扩散模型能够基于靶点口袋进行三维分子生成和先导化合物优化。

Huang, Lei; Xu, Tingyang; Yu, Yang; Zhao, Peilin; Chen, Xingjian; Han, Jing; Xie, Zhi; Li, Hailong; Zhong, Wenge; Wong, Ka-Chun; Zhang, Hengtong

Genome-wide analyses reveal the contribution of somatic variants to the immune landscape of multiple cancer types

全基因组分析揭示了体细胞变异对多种癌症类型免疫图谱的贡献

Bi, Wenjian; Xu, Zhiyu; Liu, Feng; Xie, Zhi; Liu, Hao; Zhu, Xiaotian; Zhong, Wenge; Zhang, Peipei; Tang, Xing

Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design

利用生成模型和基于结构的药物设计加速发现大环 CDK2 抑制剂 QR-6401

Yu, Yang; Huang, Junhong; He, Hu; Han, Jing; Ye, Geyan; Xu, Tingyang; Sun, Xianqiang; Chen, Xiumei; Ren, Xiaoming; Li, Chunlai; Li, Huijuan; Huang, Wei; Liu, Yangyang; Wang, Xinjuan; Gao, Yongzhi; Cheng, Nianhe; Guo, Na; Chen, Xibo; Feng, Jianxia; Hua, Yuxia; Liu, Chong; Zhu, Guoyun; Xie, Zhi; Yao, Lili; Zhong, Wenge; Chen, Xinde; Liu, Wei; Li, Hailong

Structural insights into ligand recognition and selectivity of somatostatin receptors.

生长抑素受体配体识别和选择性的结构见解

Zhao Wenli, Han Shuo, Qiu Na, Feng Wenbo, Lu Mengjie, Zhang Wenru, Wang Mu, Zhou Qingtong, Chen Shutian, Xu Wei, Du Juan, Chu Xiaojing, Yi Cuiying, Dai Antao, Hu Liaoyuan, Shen Michelle Y, Sun Yaping, Zhang Qing, Ma Yingli, Zhong Wenge, Yang Dehua, Wang Ming-Wei, Wu Beili, Zhao Qiang

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

人胰高血糖素样肽-1受体激动剂变构调节的分子机制研究

Cong, Zhaotong; Chen, Li-Nan; Ma, Honglei; Zhou, Qingtong; Zou, Xinyu; Ye, Chenyu; Dai, Antao; Liu, Qing; Huang, Wei; Sun, Xianqiang; Wang, Xi; Xu, Peiyu; Zhao, Lihua; Xia, Tian; Zhong, Wenge; Yang, Dehua; Eric Xu, H; Zhang, Yan; Wang, Ming-Wei

Structural insights into the activation of GLP-1R by a small molecule agonist

小分子激动剂激活GLP-1R的结构解析

Ma, Honglei; Huang, Wei; Wang, Xiaoxi; Zhao, Lihua; Jiang, Yi; Liu, Feng; Guo, Wei; Sun, Xianqiang; Zhong, Wenge; Yuan, Daopeng; Xu, H Eric

Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

PAC1受体的冷冻电镜结构揭示了配体结合机制

Wang, Jia; Song, Xianqiang; Zhang, Dandan; Chen, Xiaoqing; Li, Xun; Sun, Yaping; Li, Cui; Song, Yunpeng; Ding, Yao; Ren, Ruobing; Harrington, Essa Hu; Hu, Liaoyuan A; Zhong, Wenge; Xu, Cen; Huang, Xin; Wang, Hong-Wei; Ma, Yingli