日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Unveiling BCL-xL-specific PROTAC efficiency and dissociation pathways using native mass spectrometry

利用天然质谱法揭示 BCL-xL 特异性 PROTAC 效率和解离途径

Gadallah, Mohamed I; Nonhof, Kailyn L; Nayak, Digant; Zhang, Peiyi; Dioli, Olivia; Zheng, Guangrong; Olsen, Shaun K; Zhou, Daohong; Brodbelt, Jennifer S

Photo Quiz: A fatal infectious case subsequent to pecking by a rooster

图片问答:公鸡啄食后导致的致命传染病病例

Jiang, Yuansu; Zhou, Siru; Zhou, Daohong; Lu, Weiping

The Combination of a BCL-xL PROTAC and an mTOR Inhibitor Sensitizes Pancreatic Ductal Adenocarcinoma to KRAS(G12D) Inhibitor Treatment

BCL-xL PROTAC 与 mTOR 抑制剂联合应用可增强胰腺导管腺癌对 KRAS(G12D) 抑制剂治疗的敏感性

Miyan, Javed; Vudatha, Vignesh; Cao, Lin; Zhang, Peiyi; Zheng, Guangrong; Zheng, Lei; Trevino, Jose; Zhou, Daohong; Khan, Sajid

Necrotizing Fasciitis Caused by Aspergillus flavus in an Immunocompetent Young Patient: A Case Report and Literature Review

黄曲霉引起的免疫功能正常年轻患者坏死性筋膜炎:病例报告及文献综述

Sun, Wenwu; Han, Yuzhuo; Zhou, Daohong; Liu, Huayu; Zhong, Qiu

The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRAS(G12D) inhibitor treatment by enhancing apoptosis induction.

BCL-xL PROTAC 与 mTOR 抑制剂的联合作用可通过增强细胞凋亡诱导,使胰腺导管腺癌对 KRAS(G12D) 抑制剂治疗更加敏感。

Miyan Javed, Vudatha Vignesh, Cao Lin, Zhang Peiyi, Zheng Guangrong, Zheng Lei, Trevino Jose, Zhou Daohong, Khan Sajid

CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade

CTC1-STN1-TEN1 通过阻断 DNA 末端切除来控制 DNA 断裂修复途径的选择

Rogers, Cody M; Kaur, Hardeep; Swift, Michelle L; Raina, Vivek B; Zhou, Shuo; Kawale, Ajinkya S; Syed, Shahrez; Kelly, Korilynn G; Jasper, Angela M; Salunkhe, Sameer; Kwon, Youngho; Wang, Jeffrey; Shabestari, Aida Badamchi; Daley, James M; Sacks, Adam; Gaczynska, Maria E; Osmulski, Pawel A; Rawal, Yashpal; Tomimatsu, Nozomi; Gayther, Simon A; Lawrenson, Kate; Burma, Sandeep; Wasmuth, Elizabeth V; Olsen, Shaun K; Zhao, Weixing; Hromas, Robert; Libich, David S; Mazin, Alexander V; Zhou, Daohong; Greene, Eric C; Chowdhury, Dipanjan; Sung, Patrick

CD36-mediated endocytosis of proteolysis-targeting chimeras.

CD36介导的靶向蛋白水解嵌合体的内吞作用

Wang Zhengyu, Pan Bo-Syong, Manne Rajesh Kumar, Chen Jungang, Lv Dongwen, Wang Minmin, Tran Phuc, Weldemichael Tsigereda, Yan Wei, Zhou Hongfei, Martinez Gloria M, Shao Jingwei, Hsu Che-Chia, Hromas Robert, Zhou Daohong, Qin Zhiqiang, Lin Hui-Kuan, Li Hong-Yu

First in human phase 1 study of DT2216, a selective BCL-xL degrader, in patients with relapsed/refractory solid malignancies

DT2216(一种选择性 BCL-xL 降解剂)在复发/难治性实体恶性肿瘤患者中的首次人体 I 期研究

Mahadevan, Daruka; Barve, Minal; Mahalingam, Devalingam; Parekh, Jay; Kurman, Michael; Strauss, James; Tremaine, Larry; Hromas, Robert; Sills, Joshua; McCulloch, John; Harkey, John; Suberg, Stacy; Zimmerman, Lisa; Zheng, Guangrong; Zhou, Daohong

Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of JAK2-mutated post-MPN AML

新型 BCL-xL 降解剂 DT2216 在 JAK2 突变型 MPN 后 AML 临床前模型中的疗效

Wang, Zhe; Skwarska, Anna; Poigaialwar, Gowri; Chaudhry, Sovira; Rodriguez-Meira, Alba; Sui, Pinpin; Olivier, Emmanuel; Jia, Yannan; Gupta, Varun; Fiskus, Warren; Ramage, Cassandra L; Zheng, Guangrong; Schurer, Alexandra; Gritsman, Kira; Papapetrou, Eirini P; Bhalla, Kapil; Zhou, Daohong; Mead, Adam J; Rampal, Raajit K; Tyner, Jeffrey W; Abbas, Hussein A; Pemmaraju, Naveen; Tatarata, Qi Zhang; Konopleva, Marina

A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice

BCL-xL/BCL-2 PROTAC 能有效清除肝脏中的衰老细胞,并减少小鼠体内 MASH 驱动的肝细胞癌。

Yang, Yang; Jn-Simon, Natacha; He, Yonghan; Sun, Chunbao; Zhang, Peiyi; Hu, Wanyi; Tian, Tian; Zeng, Huadong; Basha, Sreenivasulu; Huerta, Araceli S; Sun, Lu-Zhe; Yin, Xian-Ming; Hromas, Robert; Zheng, Guangrong; Pi, Liya; Zhou, Daohong