Prevention of ubiquitination at K6 and K9 in mutant huntingtin exacerbates disease pathology in a knock-in mouse model
在基因敲入小鼠模型中,突变亨廷顿蛋白K6和K9位点泛素化的抑制会加剧疾病病理。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2527258122
Qi, Pengfei; Yu-Taeger, Libo; Han, Hezhou; Zhou, Junbo; Singer-Mikosch, Elisabeth; Casadei, Nicolas; Riess, Olaf; Ziv, Noam E; Ciechanover, Aaron; Phuc Nguyen, Hoa Huu