文献库，生知库 | 链接生命科学的每一步

Zhang, Cai; Zhao, Wen-Hui; Zuo, Duo; Zhou, Tianxing; Hou, Wenjing; Wang, Lingwei; Shi, Shangheng; Yang, Yang; Liu, Yuanyuan; Sun, Shao-Kai; Ren, Li; Ye, Zhaoxiang; Liu, Dingbin; Li, Dong; Chen, Xiaoyuan; Hao, Jihui

肿瘤

肿瘤免疫

发表日期：2026

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Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione-Mediated Stemness Maintenance

线粒体钙单向转运蛋白通过谷胱甘肽介导的干性维持驱动胰腺癌的化疗耐药性

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202507346

Li, Zekun; Meng, Chenyang; Shen, Guangcong; Shan, Yueying; Wang, Junjin; Abudukeremu, Diliyaer; Zhao, Rui; Ni, Bo; Xu, Chao; Guo, Xiaofan; Yu, Jun; Wang, Kaiyuan; Yang, Shengyu; Li, YunZhan; Xie, Yongjie; Zhou, Tianxing; Hao, Jihui; Wang, Xiuchao

Rationally and in silico guided APOBEC3F-directed CBE for enhanced PDAC genetic therapy

基于理性分析和计算机模拟指导的APOBEC3F靶向CBE用于增强PDAC基因治疗

期刊:Communications Biology

影响因子:5.1

doi:10.1038/s42003-026-09770-0

Fang, Qingxiao; Zhang, Jin; Wang, Keshan; Wang, Zhe; Lv, Zongjing; Zhang, Xiaoping; Bi, Changhao; Zhang, Xueli; Yu, Jun; Feng, Yukuan; Zhou, Tianxing; Hao, Jihui; Yang, Chao

Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells.

伤害感受器神经元通过与癌症相关成纤维细胞相互作用和抑制自然杀伤细胞来促进 PDAC 进展和癌症疼痛

期刊:Cell Research

影响因子:25.9

doi:10.1038/s41422-025-01098-4

Wang Kaiyuan, Ni Bo, Xie Yongjie, Li Zekun, Yuan Limei, Meng Chenyang, Zhao Tiansuo, Gao Song, Huang Chongbiao, Wang Hongwei, Ma Ying, Zhou Tianxing, Feng Yukuan, Chang Antao, Yang Chao, Yu Jun, Yu Wenwen, Zang Fenglin, Zhang Yanhui, Ji Ru-Rong, Wang Xiuchao, Hao Jihui

Prime editor with rational design and AI-driven optimization for reverse editing window and enhanced fidelity

主编辑器采用合理的设计和人工智能驱动的优化，可实现反向编辑窗口和更高的保真度。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-60495-w

Yang, Chao; Fang, Qingxiao; Li, Mengyu; Zhang, Jin; Li, Rui; Zhou, Tianxing; Wang, Keshan; Deng, Jie; Wang, Xiuchao; Huang, Chongbiao; Feng, Yukuan; Zhang, Xiaoping; Shi, Lei; Bi, Changhao; Zhang, Xueli; Yu, Jun; Hao, Jihui

发表日期：2025

文献求助收藏

β-Hydroxybutyrate promotes cancer metastasis through β-hydroxybutyrylation-dependent stabilization of Snail

β-羟基丁酸酯通过β-羟基丁酰化依赖的Snail稳定作用促进癌症转移。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-61541-3

Jiang, Wenna; Wang, Meng; Wang, Jiayi; Hao, Qianhui; Li, Yuxuan; Liu, Lin; Zhou, Tianxing; Song, Wei; Liu, Jing; Liu, Miao; Xie, Yongjie; Zuo, Duo; Xiao, Jiawei; Zhang, Xiuse; Gao, Shan; Ren, Li; Hao, Jihui

Targeting Mast Cell Activation and MIF-Mediated Remodelling Enhances Chemotherapy Response in Pancreatic Cancer.

靶向肥大细胞活化和MIF介导的重塑可增强胰腺癌的化疗反应。

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202509930

Wang Libo, Shen Guangcong, Xie Guanpeng, Li Zekun, Ma Xiaoqing, Li Mengyu, Liu Ziyun, Wang Yadi, Lv Zongjing, Fang Qingxiao, Sun Huihui, Zhao Ningning, Yang Chao, Zhou Tianxing, Xie Yongjie, Yu Jun, Hao Jihui

Identifying occult high-risk features and stratified management strategies following curative resection for ampullary adenocarcinoma

识别壶腹腺癌根治性切除术后的隐匿性高危特征和分层管理策略

期刊:Cancer Biology & Medicine

影响因子:8.4

doi:10.20892/j.issn.2095-3941.2025.0181

Ma, Xiaoqing; Meng, Chenyang; Shi, Xuejing; Zhang, Zhaoyu; Li, Qiuli; Wang, Hongwei; Liang, Yuexiang; Gao, Song; Wang, Xiuchao; Gao, Chuntao; Wang, Jian; Ma, Weidong; Feng, Yukuan; Li, Shuo; Chen, Xingyun; Li, Wei; Shi, Shangheng; Zhou, Tianxing; Yu, Jun; Hao, Jihui

CLT-003 exerts anti-tumor activity in pancreatic cancer by blocking the PI3K/AKT/HIF-1Î± pathway.

CLT-003 通过阻断 PI3K/AKT/HIF-1α 通路发挥抗胰腺癌的活性。

期刊:Cancer Biology & Medicine

影响因子:8.4

doi:10.20892/j.issn.2095-3941.2025.0058

Xu Chao, Li Zekun, Shan Yueying, She Chunhua, Yang Yanfang, Zhou Tianxing, Xie Yongjie, Ni Bo, Meng Chenyang, Shen Guangcong, Fu Boyang, Sheng Guannan, Wu Liangliang, Pei Jinlong, Zhao Tiansuo, Gao Song, Wang Hongwei, Deng Chengqi, Wang Kaiyuan, Chang Antao, Huang Chongbiao, Shi Lei, Yang Shengyu, Yu Jun, Hao Jihui, Wang Xiuchao

HCAR2 Orchestrates an Immunosuppressive Niche and Determines Checkpoint Inhibitor Responsiveness in Esophageal Squamous Cell Carcinoma

HCAR2 调控免疫抑制微环境并决定食管鳞状细胞癌对检查点抑制剂的反应性

期刊:Biological Procedures Online

影响因子:4.3

doi:10.1186/s12575-025-00305-1

Li, Zekun; Shen, Guangcong; Ma, Xiaoqing; Meng, Chenyang; Abudukeremu, Diliyaer; Zhao, Rui; Chen, Zuoyu; Song, Qiang; Guo, Xiaofan; Zhou, Tianxing; Xu, Chao; Ni, Bo; Shan, Yueying; Fu, Boyang; Chen, Yiheng; Jiang, Zhansheng; Xie, Yongjie; Wang, Kaiyuan; Wu, Liangliang; Wang, Xiuchao

AI-Guided SERS Defines a Pan-Cancer Diagnostic Biomarker

AI引导的SERS技术定义了一种泛癌诊断生物标志物

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione-Mediated Stemness Maintenance

线粒体钙单向转运蛋白通过谷胱甘肽介导的干性维持驱动胰腺癌的化疗耐药性

Rationally and in silico guided APOBEC3F-directed CBE for enhanced PDAC genetic therapy

基于理性分析和计算机模拟指导的APOBEC3F靶向CBE用于增强PDAC基因治疗

Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells.

伤害感受器神经元通过与癌症相关成纤维细胞相互作用和抑制自然杀伤细胞来促进 PDAC 进展和癌症疼痛

Prime editor with rational design and AI-driven optimization for reverse editing window and enhanced fidelity

主编辑器采用合理的设计和人工智能驱动的优化，可实现反向编辑窗口和更高的保真度。

β-Hydroxybutyrate promotes cancer metastasis through β-hydroxybutyrylation-dependent stabilization of Snail

β-羟基丁酸酯通过β-羟基丁酰化依赖的Snail稳定作用促进癌症转移。

Targeting Mast Cell Activation and MIF-Mediated Remodelling Enhances Chemotherapy Response in Pancreatic Cancer.

靶向肥大细胞活化和MIF介导的重塑可增强胰腺癌的化疗反应。

Identifying occult high-risk features and stratified management strategies following curative resection for ampullary adenocarcinoma

识别壶腹腺癌根治性切除术后的隐匿性高危特征和分层管理策略

CLT-003 exerts anti-tumor activity in pancreatic cancer by blocking the PI3K/AKT/HIF-1Î± pathway.

CLT-003 通过阻断 PI3K/AKT/HIF-1α 通路发挥抗胰腺癌的活性。

HCAR2 Orchestrates an Immunosuppressive Niche and Determines Checkpoint Inhibitor Responsiveness in Esophageal Squamous Cell Carcinoma

HCAR2 调控免疫抑制微环境并决定食管鳞状细胞癌对检查点抑制剂的反应性