日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.

吞噬受体 MERTK 和 AXL 在前粒蛋白缺乏型 FTD 中的相反作用

Clelland Claire Dudley, Fan Li, Saloner Rowan, Etchegaray Jon Iker, Altobelli Chad Richard, Salomonsson Sally, Maltos Alisha M, Sachdev Aradhana, Zhu Jingjie, Lee Se-In, Li Yaqiao, Zhou Yungui, Le David, Wang Chao, Carling Gillian, Kodama Lay, Sayed Faten, Perez-Bermejo Jaun A, Geier Ethan G, Yokoyama Jennifer S, Rosen Howie, Nana Alissa L, Spina Salvatore, Grinberg Lea T, Seeley William W, Elahi Fanny, Boxer Adam L, Arkin Michelle R, Gan Li

AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

AD相关的R47H-TREM2突变通过AKT过度激活诱导疾病增强的小胶质细胞状态

Sayed, Faten A; Kodama, Lay; Fan, Li; Carling, Gillian K; Udeochu, Joe C; Le, David; Li, Qingyun; Zhou, Lu; Wong, Man Ying; Horowitz, Rose; Ye, Pearly; Mathys, Hansruedi; Wang, Minghui; Niu, Xiang; Mazutis, Linas; Jiang, Xueqiao; Wang, Xueting; Gao, Fuying; Brendel, Matthew; Telpoukhovskaia, Maria; Tracy, Tara E; Frost, Georgia; Zhou, Yungui; Li, Yaqiao; Qiu, Yue; Cheng, Zuolin; Yu, Guoqiang; Hardy, John; Coppola, Giovanni; Wang, Fei; DeTure, Michael A; Zhang, Bin; Xie, Lei; Trajnowski, John Q; Lee, Virginia M Y; Gong, Shiaoching; Sinha, Subhash C; Dickson, Dennis W; Luo, Wenjie; Gan, Li

BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis

BMP受体阻断可克服髓鞘再生的外源性抑制,并恢复神经血管稳态。

Petersen, Mark A; Tognatta, Reshmi; Meyer-Franke, Anke; Bushong, Eric A; Mendiola, Andrew S; Yan, Zhaoqi; Muthusamy, Abinaya; Merlini, Mario; Meza-Acevedo, Rosa; Cabriga, Belinda; Zhou, Yungui; Thomas, Reuben; Ryu, Jae Kyu; Lassmann, Hans; Ellisman, Mark H; Akassoglou, Katerina

Microglial microRNAs mediate sex-specific responses to tau pathology

小胶质细胞微RNA介导对tau蛋白病理的性别特异性反应

Lay Kodama ,Elmer Guzman ,Jon I Etchegaray ,Yaqiao Li ,Faten A Sayed ,Lu Zhou ,Yungui Zhou ,Lihong Zhan ,David Le ,Joe C Udeochu ,Claire D Clelland ,Zuolin Cheng ,Guoqiang Yu ,Qingyun Li ,Kenneth S Kosik ,Li Gan

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

TREM2部分缺失和完全缺失对小胶质细胞损伤反应和tau蛋白病变的不同影响

Sayed, Faten A; Telpoukhovskaia, Maria; Kodama, Lay; Li, Yaqiao; Zhou, Yungui; Le, David; Hauduc, Axel; Ludwig, Connor; Gao, Fuying; Clelland, Claire; Zhan, Lihong; Cooper, Yonatan A; Davalos, Dimitrios; Akassoglou, Katerina; Coppola, Giovanni; Gan, Li

An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations

一项为期 8 周、开放标签、剂量探索性研究,旨在评估尼莫地平治疗 GRN 基因突变引起的粒蛋白前体缺乏症的疗效。

Sha, Sharon J; Miller, Zachary A; Min, Sang-Won; Zhou, Yungui; Brown, Jesse; Mitic, Laura L; Karydas, Anna; Koestler, Mary; Tsai, Richard; Corbetta-Rastelli, Chiara; Lin, Sophie; Hare, Emma; Fields, Scott; Fleischmann, Kirsten E; Powers, Ryan; Fitch, Ryan; Martens, Lauren Herl; Shamloo, Mehrdad; Fagan, Anne M; Farese, Robert V Jr; Pearlman, Rodney; Seeley, William; Miller, Bruce L; Gan, Li; Boxer, Adam L

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

乙酰化Tau蛋白阻碍突触可塑性中KIBRA介导的信号传导,并促进Tau蛋白病相关的记忆丧失

Tracy, Tara E; Sohn, Peter Dongmin; Minami, S Sakura; Wang, Chao; Min, Sang-Won; Li, Yaqiao; Zhou, Yungui; Le, David; Lo, Iris; Ponnusamy, Ravikumar; Cong, Xin; Schilling, Birgit; Ellerby, Lisa M; Huganir, Richard L; Gan, Li

Selective targeting of microglia by quantum dots

利用量子点选择性靶向小胶质细胞

Minami, S Sakura; Sun, Binggui; Popat, Ketul; Kauppinen, Tiina; Pleiss, Mike; Zhou, Yungui; Ward, Michael E; Floreancig, Paul; Mucke, Lennart; Desai, Tejal; Gan, Li

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease

GABA能和谷氨酸能传递失衡会损害阿尔茨海默病动物模型中的成年神经发生

Sun, Binggui; Halabisky, Brian; Zhou, Yungui; Palop, Jorge J; Yu, Guiqiu; Mucke, Lennart; Gan, Li