IDO1 inhibition enhances CLDN18.2-CAR-T cell therapy in gastrointestinal cancers by overcoming kynurenine-mediated metabolic suppression in the tumor microenvironment.
IDO1 抑制剂通过克服肿瘤微环境中犬尿氨酸介导的代谢抑制，增强 CLDN18.2-CAR-T 细胞疗法在胃肠道癌症中的疗效
期刊:Journal of Translational Medicine
影响因子:7.5
doi:10.1186/s12967-025-06276-x
Wu Zhaorong, Wang Hongye, Zheng Zhigang, Lin Yan, Bian Linke, Geng Haigang, Huang Xiaorong, Zhu Jiufei, Jing Hongshu, Zhang Yi, Ji Chen, Zhai Bo
