日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Surface-Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF-β Signaling in a Contact-Dependent Manner

细胞外囊泡表面相关蛋白通过接触依赖性方式增强TGF-β信号传导，从而重塑肿瘤微环境

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202513286
Li, Chao; Enciso-Martinez, Agustin; Zhu, Lizhe; Rotman, Sarah A; van Veelen, Peter A; Koning, Roman I; Mei, Hailiang; Ten Dijke, Peter
肿瘤
肿瘤免疫
TGF-β
信号转导
囊泡
细胞生物学
肿瘤微环境
发表日期：2026
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Structural insights into subtype-specific agonist recognition by sphingosine-1-phosphate receptors

鞘氨醇-1-磷酸受体亚型特异性激动剂识别的结构解析

期刊:PLoS Biology
影响因子:7.2
doi:10.1371/journal.pbio.3003381
Yu, Leiye; Jiao, Haizhan; Pang, Bin; Ti, Rujuan; Gan, Bing; Qin, Zhaoyang; Wang, Jinxin; Zhu, Lizhe; Hu, Hongli; Ren, Ruobing
信号转导
发表日期：2026
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A Computational Model for Nme1Cas9 HNH Activation Driven by Dynamic Interface Engineering at Residues S593 and W596

基于S593和W596残基动态界面工程驱动的Nme1Cas9 HNH活化的计算模型

期刊:Biomolecules
影响因子:4.8
doi:10.3390/biom16030358
Zhou, Zhenyu; Zhu, Lizhe
发表日期：2026
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St. Gallen International Breast Cancer Consensus-Based Clinical Decision Validation: Concordance Assessment Between Deep Large Language Model Outputs and Global Expert Panel Recommendations

圣加仑国际乳腺癌共识临床决策验证：深度大型语言模型输出与全球专家组建议的一致性评估

期刊:Annals of Surgical Oncology
影响因子:3.5
doi:10.1245/s10434-026-19176-1
Pan, Yi; Duan, Chenglong; Du, Jinsui; Zhang, Jianing; Du, Keyuan; Zhang, Chenrong; Liu, Zhihao; Zhang, Wei; Wang, Bin; Ren, Yu; Sun, Zhao; Zhu, Lizhe
肿瘤
肿瘤免疫
乳腺癌
发表日期：2026
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Structural basis of cytokinin transport by the Arabidopsis AZG2.

拟南芥 AZG2 细胞分裂素运输的结构基础

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-58802-6
Wei Hong, Yang Zhisen, Liu Huihui, Ying Wei, Gao Yongxiang, Zhu Lizhe, Liu Xin, Sun Linfeng
细胞生物学
发表日期：2025
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CXC Chemokine Ligand 12 Facilitates Gi Protein Binding to CXC Chemokine Receptor 4 by Stabilizing Packing of the Proline-Isoleucine-Phenylalanine Motif: Insights from Automated Path Searching

CXC趋化因子配体12通过稳定脯氨酸-异亮氨酸-苯丙氨酸基序的堆积来促进Gi蛋白与CXC趋化因子受体4的结合：来自自动路径搜索的启示

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.4c14293
Li, Xinyu; Liu, Yezhou; Liu, Jinchu; Ma, Wenzhuo; Ti, Rujuan; Warshel, Arieh; Ye, Richard D; Zhu, Lizhe
免疫/内分泌
信号转导
发表日期：2025
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Multicellular force coordination constructs microchannel networks for barrier-free metastasis across extracellular matrix

多细胞力协调构建微通道网络，实现跨越细胞外基质的无屏障转移

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.adz4291
Gao, Huan; Cheng, Bo; Jin, Guorui; Han, Yulong; Tian, Qi; Zhou, Yan; Zhao, Xiwen; Liu, Yan; Cao, Chunyu; Zhu, Lizhe; Zhang, Juan; Wang, Lin; Xu, Binghe; Guo, Hui; Lin, Min; Yang, Jin; Xu, Feng
细胞生物学
发表日期：2025
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RICH1 enhances pro-inflammatory TAM infiltration in breast cancer via promoting TRIM21-mediated ubiquitination of RhoA and inhibiting STAT3 phosphorylation.

RICH1 通过促进 TRIM21 介导的 RhoA 泛素化和抑制 STAT3 磷酸化来增强乳腺癌中促炎性 TAM 的浸润。

期刊:npj Precision Oncology
影响因子:8
doi:10.1038/s41698-025-01252-6
Zhou Yan, Gao Huan, Shan Liyu, Zhu Lizhe, Yang Jiao, Wang Bo, Zhang Juan, Ran Ran, Tian Qi, Liu Peijun, Yang Jin
肿瘤
表观遗传
肿瘤免疫
JAK/STAT
信号转导
泛素化
乳腺癌
STAT3
磷酸化
发表日期：2025
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Structures of G-protein coupled receptor HCAR3 in complex with selective agonists reveal the basis for ligand recognition and selectivity

G蛋白偶联受体HCAR3与选择性激动剂复合物的结构揭示了配体识别和选择性的基础

期刊:PLoS Biology
影响因子:7.2
doi:10.1371/journal.pbio.3003480
Ye, Fang; Zhang, Zhiyi; Zhang, Binghao; Li, Xinyu; Deng, Jiaxi; Miao, Qian; Ning, Peiruo; Chi, Yunlin; Chen, Geng; Wu, Zhangsong; Wang, Qian; Xu, Lezhi; Gong, Ningjie; Cheng, Bangning; Ma, Zhigang; Qian, Chungen; Zhu, Lizhe; Pan, Xin; Du, Yang
信号转导
发表日期：2025
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Structures of G-protein coupled receptor HCAR1 in complex with Gi1 protein reveal the mechanistic basis for ligand recognition and agonist selectivity.

G蛋白偶联受体HCAR1与Gi1蛋白复合物的结构揭示了配体识别和激动剂选择性的机制基础

期刊:PLoS Biology
影响因子:7.2
doi:10.1371/journal.pbio.3003126
Pan Xin, Ye Fang, Ning Peiruo, Yu Yiping, Zhang Zhiyi, Wang Jingxuan, Chen Geng, Wu Zhangsong, Qiu Chen, Li Jiancheng, Chen Bangning, Zhu Lizhe, Qian Chungen, Gong Kaizheng, Du Yang
其它
发表日期：2025
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