Zhu Man相关文献与解析，生知库 | 链接生命科学的每一步

Inferring Gene Regulatory Network Architecture Underlying Complex Traits: An Integrative Analysis of Mutant Lifespan and Gene Expression Profiles Identifies Master Regulators and Key Functional Modules for Yeast Aging

推断复杂性状背后的基因调控网络结构：突变体寿命和基因表达谱的整合分析揭示酵母衰老的关键调控因子和关键功能模块

Ma, Meng; Long, Juan; Chen, Yuting; Shao, Yanqiu; Zhu, Man; Zheng, Jiashun; Yang, Lu; Xiao, Yin; Kaeberlein, Matt; Kennedy, Brian K; Zheng, Yi; Li, Hao; Yang, Jing

信号转导

Transcription factor SPI1 drives immunosuppressive CD45+ erythroid progenitor cells to ameliorate rheumatoid arthritis

转录因子SPI1驱动免疫抑制性CD45+红系祖细胞，从而改善类风湿性关节炎

期刊:RMD Open

影响因子:5.1

doi:10.1136/rmdopen-2025-006472.

Wei-Hang Zhu #,Man-Li Wang #,Xia Meng,Shu-Yuan Zhong,Yan Liu,Yun-Feng Pan

miR-194-5p-mediated suppression of protein tyrosine phosphatase non-receptor type 12 (PTPN12) expression in the thymus enhances immunologic functional restoration in aged mice.

miR-194-5p介导的胸腺中蛋白酪氨酸磷酸酶非受体型12（PTPN12）表达抑制增强了老年小鼠的免疫功能恢复。

期刊:European Journal of Medical Research

影响因子:3.4

doi:10.1186/s40001-026-03865-4

Ai Ling-Yun, Zhu Man-Qin, Xu Wei-Man, Zou Yong, Huang Hui, Chen Ka, Shuai Xia, Hu Qing-Hua, Guo Zhi-Bin

免疫/内分泌

发表日期：2026

文献求助收藏

Unexpected perinatal death caused by an occult MTM1 mutation: a case report

一例由隐匿性MTM1基因突变引起的意外围产期死亡病例报告

期刊:Frontiers in Medicine

影响因子:3

doi:10.3389/fmed.2026.1660209

Zhu, Man-Man; Li, Dong-Mei; Wu, Yi-Cheng; Yao, Qiang; Qie, Ming-Rong; Sun, Wei-Wei

发表日期：2026

文献求助收藏

14-3-3β knockdown inhibits migration and colony formation of esophageal squamous cell carcinoma cells and is associated with weakened p-AKT signaling

14-3-3β 基因敲低抑制食管鳞状细胞癌细胞的迁移和集落形成，并与 p-AKT 信号通路减弱有关。

期刊:Hereditas

影响因子:2.5

doi:10.1186/s41065-026-00651-4

Hu, Qing-Hua; Zhu, Man-Qin; Chen, Kuai; Huang, Jin-Shi; Tao, Qiang; Guo, Zhi-Bin

Hydrophobic tagging: A promising paradigm for targeted protein degradation

疏水标记：一种用于靶向蛋白质降解的有前景的范式

期刊:Cell Insight

影响因子:

doi:10.1016/j.cellin.2025.100295

Xin, Lilan; Wang, Hongli; Yang, Maoze; Guo, Zhangxiao; Zhu, Man; Moore, Terry W; Dong, Chune; Zhou, Hai-Bing

发表日期：2026

文献求助收藏

Pathophysiologically relevant bisphenol S exposure accelerates aging by disrupting brown adipose tissue-regulated energy metabolism.

病理生理学相关的双酚S暴露会破坏棕色脂肪组织调节的能量代谢，从而加速衰老

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2420437122

Zhu Man, Wang Ru, Yi Wei, Wu Beiyi, Deng Zhizhong, Zhang Zheng, Wang Chen, Zhang Dingkun, Zhang Tongtong, Wen Xue

代谢

发表日期：2025

文献求助收藏

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species.

DNA拓扑异构酶Top2的减少会重塑表观遗传景观，延长不同物种的健康和寿命

期刊:Aging Cell

影响因子:7.1

doi:10.1111/acel.70010

Zhu Man, Ma Meng, Luo Lunan, Li Feiyang, Zheng Jiashun, Pan Yan, Yang Lu, Xiao Ying, Wang Ziyan, Xian Bo, Zheng Yi, Li Hao, Yang Jing

表观遗传

发表日期：2025

文献求助收藏

PTP-3 regulated by VB12 is important for ageing health in C. elegans.

维生素B12调控的PTP-3对秀丽隐杆线虫的衰老健康至关重要

期刊:NPJ Aging

影响因子:6

doi:10.1038/s41514-025-00201-8

Zhu Man, Lv Tao, Peng Mei, Sun Huifang, Li Yuhong

Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway

Magnolin通过调节NDRG1-NRG2-HECW1通路克服非小细胞肺癌中的EGFR TKI耐药性

Inferring Gene Regulatory Network Architecture Underlying Complex Traits: An Integrative Analysis of Mutant Lifespan and Gene Expression Profiles Identifies Master Regulators and Key Functional Modules for Yeast Aging

推断复杂性状背后的基因调控网络结构：突变体寿命和基因表达谱的整合分析揭示酵母衰老的关键调控因子和关键功能模块

Transcription factor SPI1 drives immunosuppressive CD45+ erythroid progenitor cells to ameliorate rheumatoid arthritis

转录因子SPI1驱动免疫抑制性CD45+红系祖细胞，从而改善类风湿性关节炎

miR-194-5p-mediated suppression of protein tyrosine phosphatase non-receptor type 12 (PTPN12) expression in the thymus enhances immunologic functional restoration in aged mice.

miR-194-5p介导的胸腺中蛋白酪氨酸磷酸酶非受体型12（PTPN12）表达抑制增强了老年小鼠的免疫功能恢复。

Unexpected perinatal death caused by an occult MTM1 mutation: a case report

一例由隐匿性MTM1基因突变引起的意外围产期死亡病例报告

14-3-3β knockdown inhibits migration and colony formation of esophageal squamous cell carcinoma cells and is associated with weakened p-AKT signaling

14-3-3β 基因敲低抑制食管鳞状细胞癌细胞的迁移和集落形成，并与 p-AKT 信号通路减弱有关。

Hydrophobic tagging: A promising paradigm for targeted protein degradation

疏水标记：一种用于靶向蛋白质降解的有前景的范式

Pathophysiologically relevant bisphenol S exposure accelerates aging by disrupting brown adipose tissue-regulated energy metabolism.

病理生理学相关的双酚S暴露会破坏棕色脂肪组织调节的能量代谢，从而加速衰老

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species.

DNA拓扑异构酶Top2的减少会重塑表观遗传景观，延长不同物种的健康和寿命

PTP-3 regulated by VB12 is important for ageing health in C. elegans.

维生素B12调控的PTP-3对秀丽隐杆线虫的衰老健康至关重要