日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease

一项包含56241名个体的多族裔全基因组荟萃分析,发现了已知的和新的跨人群及族裔特异性关联,这些关联被认为是阿尔茨海默病的新风险位点。

Rajabli, Farid; Benchek, Penelope; Tosto, Giuseppe; Kushch, Nicholas; Sha, Jin; Bazemore, Katrina; Zhu, Congcong; Lee, Wan-Ping; Haut, Jacob; Hamilton-Nelson, Kara L; Wheeler, Nicholas R; Zhao, Yi; Farrell, John J; Grunin, Michelle A; Leung, Yuk Yee; Kuksa, Pavel P; Li, Donghe; da Fonseca, Eder Lucio; Mez, Jesse B; Palmer, Ellen L; Pillai, Jagan; Sherva, Richard M; Song, Yeunjoo E; Zhang, Xiaoling; Ikeuchi, Takeshi; Iqbal, Taha; Pathak, Omkar; Valladares, Otto; Reyes-Dumeyer, Dolly; Kuzma, Amanda B; Abner, Erin; Adams, Larry D; Adams, Perrie M; Aguirre, Alyssa; Albert, Marilyn S; Albin, Roger L; Allen, Mariet; Alvarez, Lisa; Apostolova, Liana G; Arnold, Steven E; Asthana, Sanjay; Atwood, Craig S; Auerbach, Sanford; Ayres, Gayle; Baldwin, Clinton T; Barber, Robert C; Barnes, Lisa L; Barral, Sandra; Beach, Thomas G; Becker, James T; Beecham, Gary W; Beekly, Duane; Benitez, Bruno A; Bennett, David; Bertelson, John; Bird, Thomas D; Blacker, Deborah; Boeve, Bradley F; Bowen, James D; Boxer, Adam; Brewer, James; Burke, James R; Burns, Jeffrey M; Buxbaum, Joseph D; Cairns, Nigel J; Cantwell, Laura B; Cao, Chuanhai; Carlson, Christopher S; Carlsson, Cynthia M; Carney, Regina M; Carrasquillo, Minerva M; Chasse, Scott; Chesselet, Marie-Francoise; Chin, Nathaniel A; Chui, Helena C; Chung, Jaeyoon; Craft, Suzanne; Crane, Paul K; Cribbs, David H; Crocco, Elizabeth A; Cruchaga, Carlos; Cuccaro, Michael L; Cullum, Munro; Darby, Eveleen; Davis, Barbara; De Jager, Philip L; DeCarli, Charles; DeToledo, John; Dick, Malcolm; Dickson, Dennis W; Dombroski, Beth A; Doody, Rachelle S; Duara, Ranjan; Ertekin-Taner, NIlüfer; Evans, Denis A; Faber, Kelley M; Fairchild, Thomas J; Fallon, Kenneth B; Fardo, David W; Farlow, Martin R; Fernandez-Hernandez, Victoria; Ferris, Steven; Friedland, Robert P; Foroud, Tatiana M; Frosch, Matthew P; Fulton-Howard, Brian; Galasko, Douglas R; Gamboa, Adriana; Gearing, Marla; Geschwind, Daniel H; Ghetti, Bernardino; Gilbert, John R; Go, Rodney C P; Goate, Alison M; Grabowski, Thomas J; Graff-Radford, Neill R; Green, Robert C; Growdon, John H; Hakonarson, Hakon; Hall, James; Hamilton, Ronald L; Harari, Oscar; Hardy, John; Harrell, Lindy E; Head, Elizabeth; Henderson, Victor W; Hernandez, Michelle; Hohman, Timothy; Honig, Lawrence S; Huebinger, Ryan M; Huentelman, Matthew J; Hulette, Christine M; Hyman, Bradley T; Hynan, Linda S; Ibanez, Laura; Jarvik, Gail P; Jayadev, Suman; Jin, Lee-Way; Johnson, Kim; Johnson, Leigh; Kamboh, M Ilyas; Karydas, Anna M; Katz, Mindy J; Kauwe, John S; Kaye, Jeffrey A; Keene, C Dirk; Khaleeq, Aisha; Kikuchi, Masataka; Kim, Ronald; Knebl, Janice; Kowall, Neil W; Kramer, Joel H; Kukull, Walter A; LaFerla, Frank M; Lah, James J; Larson, Eric B; Lerner, Alan; Leverenz, James B; Levey, Allan I; Lieberman, Andrew P; Lipton, Richard B; Logue, Mark; Lopez, Oscar L; Lunetta, Kathryn L; Lyketsos, Constantine G; Mains, Douglas; Margaret, Flanagan E; Marson, Daniel C; Martin, Eden Rr; Martiniuk, Frank; Mash, Deborah C; Masliah, Eliezer; Massman, Paul; Masurkar, Arjun; McCormick, Wayne C; McCurry, Susan M; McDavid, Andrew N; McDonough, Stefan; McKee, Ann C; Mesulam, Marsel; Miller, Bruce L; Miller, Carol A; Miller, Joshua W; Montine, Thomas J; Monuki, Edwin S; Morris, John C; Mukherjee, Shubhabrata; Myers, Amanda J; Nguyen, Trung; Obisesan, Thomas; O'Bryant, Sid; Olichney, John M; Ory, Marcia; Palmer, Raymond; Parisi, Joseph E; Paulson, Henry L; Pavlik, Valory; Paydarfar, David; Perez, Victoria; Peskind, Elaine; Petersen, Ronald C; Petrovitch, Helen; Pierce, Aimee; Polk, Marsha; Poon, Wayne W; Potter, Huntington; Qu, Liming; Quiceno, Mary; Quinn, Joseph F; Raj, Ashok; Raskind, Murray; Reiman, Eric M; Reisberg, Barry; Reisch, Joan S; Ringman, John M; Roberson, Erik D; Rodriguear, Monica; Rogaeva, Ekaterina; Rosen, Howard J; Rosenberg, Roger N; Royall, Donald R; Sabbagh, Marwan; Sadovnick, A Dessa; Sager, Mark A; Sano, Mary; Saykin, Andrew J; Schneider, Julie A; Schneider, Lon S; Seeley, William W; Slifer, Susan H; Small, Scott; Smith, Amanda G; Smith, Janet P; Sonnen, Joshua A; Spina, Salvatore; George-Hyslop, Peter St; Starks, Takiyah D; Stern, Robert A; Stevens, Alan B; Strittmatter, Stephen M; Sultzer, David; Swerdlow, Russell H; Tanzi, Rudolph E; Tilson, Jeffrey L; Trojanowski, John Q; Troncoso, Juan C; Tsolaki, Magda; Tsuang, Debby W; Van Deerlin, Vivianna M; van Eldik, Linda J; Vance, Jeffery M; Vardarajan, Badri N; Vassar, Robert; Vinters, Harry V; Vonsattel, Jean-Paul; Weintraub, Sandra; Welsh-Bohmer, Kathleen A; Whitehead, Patrice L; Wijsman, Ellen M; Wilhelmsen, Kirk C; Williams, Benjamin; Williamson, Jennifer; Wilms, Henrik; Wingo, Thomas S; Wisniewski, Thomas; Woltjer, Randall L; Woon, Martin; Wright, Clinton B; Wu, Chuang-Kuo; Younkin, Steven G; Yu, Chang-En; Yu, Lei; Zhu, Xiongwei; Kunkle, Brian W; Bush, William S; Miyashita, Akinori; Byrd, Goldie S; Wang, Li-San; Farrer, Lindsay A; Haines, Jonathan L; Mayeux, Richard; Pericak-Vance, Margaret A; Schellenberg, Gerard D; Jun, Gyungah R; Reitz, Christiane; Naj, Adam C

Amyloid-beta glycation induces neuronal mitochondrial dysfunction and Alzheimer's pathogenesis via VDAC1-dependent mtDNA efflux

β-淀粉样蛋白糖基化通过VDAC1依赖的线粒体DNA外流诱导神经元线粒体功能障碍和阿尔茨海默病的发病机制。

Akhter, Firoz; Akhter, Asma; Zhu, Xiongwei; Schiff, Hillary; Maffei, Arianna; Douglas, Justin T; Zhou, Qifa; Zhao, Zhen; Zhu, Donghui

The unique reactivity of EKODE lipid peroxidation products allows in vivo detection of inflammation

EKODE脂质过氧化产物的独特反应活性使其能够在体内检测炎症。

Shi, Chuan; Eskandari, Roozbeh; Zhang, Jianye; Zhang, Guofang; Li, Li; Hawkins, Deandrea; Zhu, Xiongwei; Tochtrop, Gregory P

Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury

抑制15-PGDH可阻止血脑屏障的破坏,并保护小鼠免受阿尔茨海默病和创伤性脑损伤。

Koh, Yeojung; Vázquez-Rosa, Edwin; Gao, Farrah; Li, Hongyun; Chakraborty, Suwarna; Tripathi, Sunil Jamuna; Barker, Sarah; Bud, Zea; Bangalore, Anusha; Kandjoze, Uapingena P; León-Alvarado, Rose A; Sridharan, Preethy S; Cordova, Brittany A; Yu, Youngmin; Hyung, Jiwon; Fang, Hua; Singh, Salendra; Katabathula, Ramachandra; LaFramboise, Thomas; Kasturi, Lakshmi; Lutterbaugh, James; Beard, Lydia; Cordova, Erika; Cintrón-Pérez, Coral J; Franke, Kathryn; Fragoso, Mariana Franco; Miller, Emiko; Indrakumar, Vidya; Noel, Kamryn L; Dhar, Matasha; Ajroud, Kaouther; Zamudio, Carlos; Lopes, Filipa Blasco Tavares Pereira; Bambakidis, Evangeline; Zhu, Xiongwei; Wilson, Brigid; Flanagan, Margaret E; Gefen, Tamar; Fujioka, Hisashi; Fink, Stephen P; Desai, Amar B; Dawson, Dawn; Williams, Noelle S; Kim, Young-Kwang; Ready, Joseph M; Paul, Bindu D; Shin, Min-Kyoo; Markowitz, Sanford D; Pieper, Andrew A

A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson's disease

基于网络的系统遗传学框架揭示了帕金森病的病理生物学和药物再利用机制

Dou, Lijun; Xu, Zhenxing; Xu, Jielin; Zang, Chengxi; Su, Chang; Pieper, Andrew A; Leverenz, James B; Wang, Fei; Zhu, Xiongwei; Cummings, Jeffrey; Cheng, Feixiong

Chronic ethanol administration exacerbates memory loss by altering N6-methyladenosine-mediated epigenetic signaling

长期摄入乙醇会通过改变N6-甲基腺苷介导的表观遗传信号传导加剧记忆丧失。

Liao, Yuanhang; Xu, Fu; Yan, Yuqing; Zhou, Sicheng; Liu, Na; Dou, Baomin; Srinivasan, Nivetha; Wang, Weizheng; Zhu, Xiongwei; Ye, Jianghong; Xu, Ying

Structural exposure of different microtubule binding domains determines the propagation and toxicity of pathogenic tau conformers in Alzheimer's disease.

不同微管结合域的结构暴露决定了阿尔茨海默病中致病性 tau 构象体的传播和毒性

Hromadkova Lenka, Kim Chae, Haldiman Tracy, Siddiqi Mohammad Khursheed, Surewicz Krystyna, Urquhart Kiley, Sadruddin Dur-E-Nayab, Peng Lihua, Zhu Xiongwei, Surewicz Witold K, Cohen Mark L, Chance Mark R, de Silva Rohan, Kiselar Janna, Safar Jiri G

Inspecting the Triazole Scaffold as Powerful Antifibril Agents against 2N4R Tau and α-Synuclein Aggregates

研究三唑骨架作为对抗 2N4R Tau 和 α-突触核蛋白聚集体的强效抗纤维剂

Elbatrawy, Ahmed A; Ademoye, Taiwo A; Alnakhala, Heba; Tripathi, Arati; Zhu, Xiongwei; Plascencia-Villa, Germán; Perry, George; Dettmer, Ulf; Fortin, Jessica S

Cell type-specific master metabolic regulators of Alzheimer's disease.

阿尔茨海默病细胞类型特异性主代谢调节因子

Qiu Yunguang, Hou Yuan, Wetzel Liam, Caldwell Jessica Z K, Zhu Xiongwei, Pieper Andrew A, Liu Tian, Cheng Feixiong

Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's disease.

系统性地表征阿尔茨海默病中细胞类型特异性主代谢调节因子

Qiu Yunguang, Hou Yuan, Wetzel Liam, Caldwell Jessica Z K, Zhu Xiongwei, Pieper Andrew A, Liu Tian, Cheng Feixiong