日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Decoding unchanged transcriptome of Alzheimer's disease reveals an NCAM1 mRNA switch as a potential biomarker

对阿尔茨海默病未改变的转录组进行解码,揭示了NCAM1 mRNA开关作为潜在生物标志物的作用

Li, Haotian; Liu, Sai; Miao, Daoxin; Chen, Long; Sun, Yuan; Wang, Guangji; Zhu, Zheying; Li, Xinuo; Lu, Qiulun

PROTAC-mediated multi-target protein degradation in Alzheimer's disease: mechanistic insights, therapeutic applications, and translational challenges

PROTAC介导的多靶点蛋白降解在阿尔茨海默病中的作用:机制解析、治疗应用及转化挑战

Wang, Bin; Li, Yunan; Yao, Tingting; Shen, Xinai; Li, Huan; Jiang, Wei; Li, Xinuo; Zhu, Zheying

Spaceflight redefines ageing-associated microbiota

太空飞行重新定义了与衰老相关的微生物群

Sun, Yuan; Liu, Sai; Chen, Long; Zhou, Zheng; Ma, Mengyu; Li, Jinran; Lu, Yi; Shi, Yiting; Yao, Tingting; Feng, Ruizhi; Lu, Qiulun; Qassadi, Fatimah; Williams, Philip M; Monaghan, Tanya M; Wang, Guangji; Zhu, Zheying; Li, Xinuo

AI-driven discovery of dual antiaging and anti-AD therapeutics via PROTAC target deconvolution of a super-enhancer-regulated axis

利用PROTAC靶点解卷积技术,通过人工智能驱动的超级增强子调控轴,发现双重抗衰老和抗阿尔茨海默病疗法。

Sun, Yuan; Liu, Sai; Chen, Long; Zhou, Zheng; Yin, Xin; Shi, Yiting; Li, Haotian; Li, Jinran; Lu, Yi; Jiang, Wei; Zhao, Yongjun; Dai, Tucheng; Yao, Tingting; Li, Anbo; Bi, Xinyu; Zhang, Beiyu; Shen, Xinai; Zhu, Zheying; Wang, Guangji; Li, Xinuo

Tau-Targeted Therapeutic Strategies: Mechanistic Targets, Clinical Pipelines, and Analysis of Failures

针对Tau蛋白的治疗策略:机制靶点、临床研发管线及失败案例分析

Shen, Xinai; Li, Huan; Zhang, Beiyu; Li, Yunan; Zhu, Zheying

Untargeted Metabolomics Identifies Faecal Filtrate-Derived Metabolites That Disrupt Clostridioides difficile Metabolism and Confer Gut Barrier Cytoprotection

非靶向代谢组学鉴定出粪便滤液衍生的代谢物,这些代谢物会破坏艰难梭菌代谢并赋予肠道屏障细胞保护作用

Qassadi, Fatimah I; Johnson, Charlotte; Robinson, Karen; Griffin, Ruth; Polytarchou, Christos; Kao, Dina; Kim, Dong-Hyun; Griffiths, Rian L; Zhu, Zheying; Monaghan, Tanya M

Targeting Transferrin Receptor 1 for Enhancing Drug Delivery Through the Blood-Brain Barrier for Alzheimer's Disease

靶向转铁蛋白受体1以增强药物通过血脑屏障的递送,用于治疗阿尔茨海默病

Shen, Xinai; Li, Huan; Zhang, Beiyu; Li, Yunan; Zhu, Zheying

Transferrin-Functionalized Liposomes Enhance MAPT-ASO Transport Across a 3D Blood-Brain Barrier Microvascular Network Model.

转铁蛋白功能化脂质体增强 MAPT-ASO 在 3D 血脑屏障微血管网络模型中的运输。

Konig Simon, Shen Xinai, Mantovani Giuseppe, Winkler Gerlof Sebastiaan, Zhu Zheying, Moeendarbary Emad

Biologics as Therapeutical Agents Under Perspective Clinical Studies for Alzheimer's Disease

生物制剂作为治疗药物在阿尔茨海默病临床研究中的应用前景

Li, Huan; Shen, Xinai; Zhang, Beiyu; Zhu, Zheying

Therapeutic Advances in Targeting the Amyloid-β Pathway for Alzheimer's Disease

靶向β-淀粉样蛋白通路治疗阿尔茨海默病的新进展

Zhang, Beiyu; Li, Yunan; Li, Huan; Shen, Xinai; Zhu, Zheying