Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors.
2-氨基嘧啶基大环化合物的后口袋优化可得到强效的EPHA2/GAK激酶抑制剂
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c00411
Gerninghaus Joshua, Zhubi Rezart, Krämer Andreas, Karim Marwah, Tran Do Hoang Nhu, Joerger Andreas C, Schreiber Christian, Berger Lena M, Berger Benedict-Tilman, Ehret Theresa A L, Elson Lewis, Lenz Christopher, Saxena Krishna, Müller Susanne, Einav Shirit, Knapp Stefan, Hanke Thomas
