Zhuchi相关文献与解析，生知库 | 链接生命科学的每一步

Xichen Song,Caijuan Li,Yang Yang,Chunhui Huang,Min Chen,Song Lin,Zhonghai Huang,Wei Wang,Kai Liao,Huiyi Wei,Lu Wang,Hao Xu,Yizhi Chen,Yingqi Lin,Jiawei Li,Zhen Dai,Wenguang Xie,Xiao Zheng,Jianhao Wu,Jiale Gao,Jiaxi Wu,Zhuchi Tu,Libing Zhou,Lu Huang,Chaoran Ren,Kwok-Fai So,Peng Yin,Huiming Yang,Shihua Li,Liangxue Lai,Xiao-Jiang Li,Sen Yan

Monkey

细胞生物学

神经科学

Single-nucleus RNA sequencing dataset of diverse tissues from wild-type monkey and Tau-P301L transgenic monkey

来自野生型猴和Tau-P301L转基因猴的多种组织的单核RNA测序数据集

期刊:Scientific Data

影响因子:6.9

doi:10.1038/s41597-026-06882-4

Han, Bofeng; Chen, Yan; Ouyang, Weijie; Chen, Danyi; Li, Jiawei; Liang, Weien; Zhang, Xudong; Wei, Chengxi; Liu, Ling; Yan, Sen; Tu, Zhuchi

发表日期：2026

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RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington's disease models

RNA 靶向 CRISPR/CasRx 系统可缓解亨廷顿氏病模型中的疾病症状

期刊:Molecular Neurodegeneration

影响因子:14.9

doi:10.1186/s13024-024-00794-w

Yingqi Lin #, Caijuan Li #, Yizhi Chen #, Jiale Gao, Jiawei Li, Chunhui Huang, Zhaoming Liu, Wei Wang, Xiao Zheng, Xichen Song, Jianhao Wu, Jiaxi Wu, Oscar Junhong Luo, Zhuchi Tu, Shihua Li, Xiao-Jiang Li, Liangxue Lai, Sen Yan

A Novel Genetic TDP-43 Pig Model Mimics Multiple Key ALS-Like Features.

一种新型的TDP-43基因猪模型模拟了多种ALS的关键特征。

期刊:MedComm

影响因子:10.7

doi:10.1002/mco2.70330

Huang Chunhui, Zheng Xiao, Wu Jiaxi, Li Jiawei, Lin Yingqi, Chen Yizhi, Li Caijuan, Song Xichen, Wang Wei, Liu Zhaoming, Wu Jianhao, Gao Jiale, Tu Zhuchi, Zhang Zaijun, Lai Liangxue, Li Shihua, Li Xiao-Jiang, Yan Sen

ALS

发表日期：2025

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Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models

帕金蛋白缺乏导致猴子模型中的神经退化和病理性 α-突触核蛋白的积累

期刊:Journal of Clinical Investigation

影响因子:13.3

doi:10.1172/JCI179633

Rui Han, Qi Wang, Xin Xiong, Xiusheng Chen, Zhuchi Tu, Bang Li, Fei Zhang, Chunyu Chen, Mingtian Pan, Ting Xu, Laiqiang Chen, Zhifu Wang, Yanting Liu, Dajian He, Xiangyu Guo, Feng He, Peng Wu, Peng Yin, Yunbo Liu, Xiaoxin Yan, Shihua Li, Xiao-Jiang Li, Weili Yang

Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta

抑制UBE2N可通过清除β-淀粉样蛋白来改善阿尔茨海默病病理。

期刊:Alzheimers & Dementia

影响因子:13

doi:10.1002/alz.14122

Chen Zhang ，Qingqing Jia ，Longhong Zhu ，Junqi Hou ，Xiang Wang ，Dandan Li ，Jiawei Zhang ，Yiran Zhang ，Su Yang ，Zhuchi Tu ，Xiao-Xin Yan ，Weili Yang ，Shihua Li ，Xiao-Jiang Li ，Peng Yin

阿尔茨海默症

发表日期：2024

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Large animal models for Huntington's disease research

用于亨廷顿舞蹈症研究的大型动物模型

期刊:Zoological Research

影响因子:4.7

doi:10.24272/j.issn.2095-8137.2023.199

Han, Bofeng; Liang, Weien; Li, Xiao-Jiang; Li, Shihua; Yan, Sen; Tu, Zhuchi

发表日期：2024

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Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys

Tau 蛋白病促进转基因猴脊髓依赖性毒性淀粉样蛋白 β 的产生

期刊:Signal Transduction and Targeted Therapy

影响因子:40.8

doi:10.1038/s41392-023-01601-6

Zhuchi Tu #, Sen Yan #, Bofeng Han, Caijuan Li, Weien Liang, Yingqi Lin, Yongyan Ding, Huiyi Wei, Lu Wang, Hao Xu, Jianmeng Ye, Bang Li, Shihua Li, Xiao-Jiang Li

信号转导

发表日期：2023

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Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

使用碱基编辑生成患有严重联合免疫缺陷的失活 IL2RG 和 RAG1 猴

期刊:Signal Transduction and Targeted Therapy

影响因子:40.8

doi:10.1038/s41392-023-01544-y

Xiao Zheng #, Chunhui Huang #, Yingqi Lin, Bofeng Han, Yizhi Chen, Caijuan Li, Jiawei Li, Yongyan Ding, Xichen Song, Wei Wang, Weien Liang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Chengxi Wei, Xudong Zhang, Zhuchi Tu, Sen Yan

免疫

发表日期：2023

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CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

CHD8 突变会增加非人灵长类动物的神经胶质细胞生成，从而增大大脑体积。

期刊:Cell Discovery

影响因子:13

doi:10.1038/s41421-023-00525-3

Bang Li # ,Hui Zhao # ,Zhuchi Tu # ,Weili Yang # ,Rui Han ,Lu Wang ,Xiaopeng Luo ,Mingtian Pan ,Xiusheng Chen ,Jiawei Zhang ,Huijuan Xu ,Xiangyu Guo ,Sen Yan ,Peng Yin ,Zhiguang Zhao ,Jianrong Liu ,Yafeng Luo ,Yuefeng Li ,Zhengyi Yang ,Baogui Zhang ,Zhiqiang Tan ,Hao Xu ,Tianzi Jiang ,Yong-Hui Jiang ,Shihua Li ,Yong Q Zhang ,Xiao-Jiang Li

Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys

利用诱导干细胞缓解猴子体内突变型TDP-43介导的神经病理学

Single-nucleus RNA sequencing dataset of diverse tissues from wild-type monkey and Tau-P301L transgenic monkey

来自野生型猴和Tau-P301L转基因猴的多种组织的单核RNA测序数据集

RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington's disease models

RNA 靶向 CRISPR/CasRx 系统可缓解亨廷顿氏病模型中的疾病症状

A Novel Genetic TDP-43 Pig Model Mimics Multiple Key ALS-Like Features.

一种新型的TDP-43基因猪模型模拟了多种ALS的关键特征。

Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models

帕金蛋白缺乏导致猴子模型中的神经退化和病理性 α-突触核蛋白的积累

Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta

抑制UBE2N可通过清除β-淀粉样蛋白来改善阿尔茨海默病病理。

Large animal models for Huntington's disease research

用于亨廷顿舞蹈症研究的大型动物模型

Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys

Tau 蛋白病促进转基因猴脊髓依赖性毒性淀粉样蛋白 β 的产生

Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

使用碱基编辑生成患有严重联合免疫缺陷的失活 IL2RG 和 RAG1 猴

CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

CHD8 突变会增加非人灵长类动物的神经胶质细胞生成，从而增大大脑体积。