日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Physiologic recovery of Mycobacterium tuberculosis from drug injury: A molecular study of post antibiotic effect in vitro and in vivo

结核分枝杆菌药物损伤后的生理恢复:体外和体内抗生素后效应的分子研究

Hendrix, Jo; Al Mubarak, Reem; Reichlen, Matthew J; Tabor, Samuel T; Bateman, Adeline; Massoudi, Lisa M; Rossmassler, Karen; Kaya, Firat; Zimmerman, Matthew D; Nielsen, Holly; Wynn, Elizabeth A; Voskuil, Martin I; Robertson, Gregory T; Moore, Camille M; Walter, Nicholas D

Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection.

化学遗传相互作用阐明了结核病感染期间控制抗生素疗效的途径

Oluoch Peter O, Koh Eun-Ik, Proulx Megan K, Reames Charlotte J, Papavinasasundaram Kadamba G, Murphy Kenan C, Zimmerman Matthew D, Dartois Véronique, Sassetti Christopher M

Tailored phenyl ureas eradicate drug-resistant Mycobacterium tuberculosis by targeting mycolic acid cell wall assembly

定制的苯脲类化合物通过靶向分枝菌酸细胞壁组装来根除耐药结核分枝杆菌。

Mostert, Dietrich; Braun, Josef; Zimmerman, Matthew D; Engelhart, Curtis A; Berndl, Sara; Quoika, Patrick K; Kany, Andreas M; Proietto, Julianna; Penalva-Lopez, Suyapa; Wallach, Joshua B; Hirsch, Anna K H; Zacharias, Martin; Schnappinger, Dirk; Dartois, Véronique; Sieber, Stephan A

Evolution of Small Molecule Inhibitors of Mycobacterium tuberculosis Menaquinone Biosynthesis

结核分枝杆菌甲萘醌生物合成小分子抑制剂的演变

Sharma, Pankaj; Jiang, Quan; Li, Shao-Gang; Ocke, Elissa; Tsotetsi, Kholiswa; Sukheja, Paridhi; Singh, Parul; Suryavanshi, Shraddha; Morrison, Ethan; Thadkapally, Srinivas; Russo, Riccardo; Penalva-Lopez, Suyapa; Cangialosi, Julianna; Sharma, Vijeta; Johnson, Kyla; Sarathy, Jansy P; Nelson, Andrew M; Park, Steven; Zimmerman, Matthew D; Alland, David; Kumar, Pradeep; Freundlich, Joel S

The Kinetics of Bedaquiline Diffusion in Tuberculous Cavities Open a Window for the Emergence of Resistance

贝达喹啉在结核空洞中的扩散动力学为耐药性的出现打开了一扇窗。

Bustion, Annamarie E; Ernest, Jacqueline P; Kaya, Firat; Silva, Connie; Sarathy, Jansy; Blanc, Landry; Imperial, Marjorie; Gengenbacher, Martin; Xie, Min; Zimmerman, Matthew D; Robertson, Gregory T; Weiner, Danielle; Via, Laura E; Barry, Clifton E; Savic, Radojka M; Dartois, Véronique

Identification of Antituberculars with Favorable Potency and Pharmacokinetics through Structure-Based and Ligand-Based Modeling

通过基于结构和基于配体的建模方法筛选具有良好效力和药代动力学特性的抗结核药物

Warapande, Vedang; Meng, Fanwang; Bozan, Alexandra; Graff, David E; Fromer, Jenna C; Mughal, Khadija; Mohideen, Faheem K; Shivangi; Paruchuri, Sindhuja; Johnston, Melanie L; Sharma, Pankaj; Crea, Timothy R; Rudraraju, Reshma S; George, Amir; Folvar, Camilla; Nelson, Andrew M; Neiditch, Matthew B; Zimmerman, Matthew D; Coley, Connor W; Freundlich, Joel S

Structure-Guided Development of a Potent BioA Inhibitor Validates Biotin Synthesis Inhibition as a Therapeutic Strategy for Tuberculosis

结构导向开发高效BioA抑制剂验证了生物素合成抑制作为结核病治疗策略的有效性

Liu, Qiang; Wallach, Joshua B; Jayasinghe, Yahani P; Sullivan, Mark R; Proietto, Julianna; Rodriguez, Suyapa; Vo, Sang; Boshoff, Helena I M; Jia, Ziyi; Ostrer, Lev; Mehdiratta, Kritee; Shi, Rui; Dartois, Véronique; Baughn, Anthony D; Rubin, Eric J; Ronning, Donald R; Zimmerman, Matthew D; Schnappinger, Dirk; Aldrich, Courtney C

Small Molecule Benzothiophene with In Vivo Efficacy in a Mouse Model of Drug-Resistant Enterococcus faecium Infection

小分子苯并噻吩在耐药性粪肠球菌感染小鼠模型中具有体内疗效

Gallardo-Macias, Ricardo; Russo, Riccardo; Sherwood, Matthew; Jaskowski, Mark; Nasser, Wissam; Sharma, Pankaj; Tuckman, Margareta; Singleton, Eric; Ho, Hsin Pin; Park, Steven; Patel, Jimmy S; George, Amir; Perlin, David; Zimmerman, Matthew D; Connell, Nancy; Freundlich, Joel S

Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis

Spectinamide MBX-4888A 在晚期小鼠结核病模型中表现出良好的病灶和组织分布,并能缩短治疗时间。

Bauman, Allison A; Sarathy, Jansy P; Kaya, Firat; Massoudi, Lisa M; Scherman, Michael S; Hastings, Courtney; Liu, Jiuyu; Xie, Min; Brooks, Elizabeth J; Ramey, Michelle E; Jones, Isabelle L; Benedict, Noalani D; Maclaughlin, Madelyn R; Miller-Dawson, Jake A; Waidyarachchi, Samanthi L; Butler, Michelle M; Bowlin, Terry L; Zimmerman, Matthew D; Lenaerts, Anne J; Meibohm, Bernd; Gonzalez-Juarrero, Mercedes; Lyons, Michael A; Dartois, Veronique; Lee, Richard E; Robertson, Gregory T

Enhancing the therapeutic window for Spectinamide anti-tuberculosis Agents: Synthesis, Evaluation, and activation of phosphate prodrug 3408

扩大Spectinamide抗结核药物的治疗窗口:磷酸前药3408的合成、评价和活化

Liu, Jiuyu; Lukka, Pradeep B; Ektnitphong, Victoria A; Parmar, Keyur R; Wagh, Santosh; Lu, Yan; Lee, Robin B; Scherbakov, Dimitri; Wang, Han; Zimmerman, Matthew D; Meibohm, Bernd; Robertson, Gregory T; Dartois, Vêronique; Böttger, Erik C; Lenaerts, Anne J; Lee, Richard E