日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Camonsertib, an ATRi, in Combination with Low-Dose Gemcitabine in Solid Tumors with DNA Damage Response Aberrations: Preclinical and Phase Ib Results

Camonsertib(一种ATRi)联合低剂量吉西他滨治疗伴有DNA损伤反应异常的实体瘤:临床前和Ib期研究结果

Rosen, Ezra Y; Yap, Timothy A; Fontana, Elisa; Lee, Elizabeth K; Mahalingam, Devalingam; Højgaard, Martin; Mettu, Niharika B; Cote, Gregory M; Plummer, Ruth; Koehler, Maria; Ulanet, Danielle; Fei, Kezhen; Silverman, Ian M; Schonhoft, Joseph D; Rimkunas, Victoria; Bacque, Emeline S; Gomez, Gabriela; Fretland, Adrian J; Roulston, Anne; Li, Li; Baruah, Prasamit; Zimmermann, Michal; Yang, Julia; Carneiro, Benedito A; Lheureux, Stephanie

Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ

设计靶向共价探针以检测Polθ的DNA聚合酶活性

Bubenik, Monica; Mader, Pavel; Orlicky, Stephen; Perryman, Alexander L; Hamel, Martine; Godbout, Claude; Falgueyret, Jean-Pierre; Kurinov, Igor; Wong, Cassandra; Gingras, Anne Claude; Mamane, Yael; Zinda, Michael; Morris, Stephen J; Gallant, Michel; Sfeir, Agnel; Black, W Cameron; Durocher, Daniel; Zimmermann, Michal; Sicheri, Frank

Exceptional response to the ATR inhibitor, camonsertib, in a patient with ALT+ metastatic melanoma

ATR抑制剂camonsertib在一名ALT+转移性黑色素瘤患者中表现出卓越的疗效

Ngoi, Natalie Y L; Silverman, Ian M; Johnson, Adrienne; Meng, Chenfeng; Schonhoft, Joseph D; Zimmermann, Michal; Ulanet, Danielle; Kim, Hyeyeon; Torrado, Carlos; Salguero, Carolina; Brown, Christian Valladolid; Rodon, Jordi; Rimkunas, Victoria; Koehler, Maria; Yap, Timothy A

The PLK4 inhibitor RP-1664 demonstrates potent single-agent efficacy in neuroblastoma models through a dual mechanism of sensitivity.

PLK4 抑制剂 RP-1664 通过双重敏感性机制在神经母细胞瘤模型中表现出强大的单药疗效

Maris John, Soria-Bretones Isabel, Casás-Selves Matias, Samanta Minu, Groff David, Murray Jayne, Fletcher Jamie, Farrel Alvin, Pastor Steven, Patel Khushbu, Goodfellow Elliot Goodfellow, Li Li, Caron Cathy, Shiwram Ariya, Kim Hyeyeon, Henry Danielle, Laterreur Nancy, Bowlan Julian, Krytska Kateryna, Neuhauser Steven, Stearns Timothy, Schubert Jeffrey, Wu Jinhua, Surrey Lea, Álvarez-Quilón Alejandro, Vallée Frédéric, Nejad Parham, Schonhoft Joseph, Li Joanna, Veloso Artur, Young Jordan, Hyer Marc, Morris Stephen, Mossé Yael P, Marshall Gary, Haber Michelle, Zimmermann Michal

Synthetic Lethality in Cancer Therapeutics: The Next Generation

癌症治疗中的合成致死:下一代

Setton, Jeremy; Zinda, Michael; Riaz, Nadeem; Durocher, Daniel; Zimmermann, Michal; Koehler, Maria; Reis-Filho, Jorge S; Powell, Simon N

53BP1: pro choice in DNA repair

53BP1:DNA修复中的促选择

Zimmermann, Michal; de Lange, Titia