日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Therapeutic potential of allosteric HECT E3 ligase inhibition.

变构 HECT E3 连接酶抑制的治疗潜力

Rothman Alexander M K, Florentin Amir, Zink Florence, Quigley Catherine, Bonneau Olivier, Hemmig Rene, Hachey Amanda, Rejtar Tomas, Thaker Maulik, Jain Rishi, Huang Shih-Min, Sutton Daniel, Roger Jan, Zhang Ji-Hu, Weiler Sven, Cotesta Simona, Ottl Johannes, Srivastava Salil, Kordonsky Alina, Avishid Reut, Yariv Elon, Rathi Ritu, Khvalevsky Oshrit, Troxler Thomas, Binmahfooz Sarah K, Kleifeld Oded, Morrell Nicholas W, Humbert Marc, Thomas Matthew J, Jarai Gabor, Beckwith Rohan E J, Cobb Jennifer S, Smith Nichola, Ostermann Nils, Tallarico John, Shaw Duncan, Guth-Gundel Sabine, Prag Gali, Rowlands David J

Identification and characterization of binders to a cryptic and functional pocket in KRAS

鉴定和表征KRAS中隐蔽功能口袋的结合蛋白

Beyer, Kim S; Klein, Jessica; Katz, Stéphanie; Welker, Patrick; Lanter, Mylene; Guthy, Daniel; Pollehn, Kerstin; Gluck-Gadé, Aurélie; Bleu, Melusine; Desogus, Jessica; Hattenberger, Marc; Borrello, Damiano; Abdul Rahman, Wassim; Zink, Florence; Ostermann, Nils; Jahnke, Wolfgang; Dumelin, Christoph E; Leder, Lukas; Esser, Oliver; Muller, Lionel; Marzinzik, Andreas; Cébé, Regis; Müller, Kathrin; Galli, Giorgio G; Tordella, Luca; Cotesta, Simona; Brachmann, Saskia M; Maira, Sauveur-Michel

Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases

发现TLR7/8拮抗剂MHV370用于治疗系统性自身免疫性疾病

Alper, Phil; Betschart, Claudia; André, Cédric; Boulay, Thomas; Cheng, Dai; Deane, Jonathan; Faller, Michael; Feifel, Roland; Glatthar, Ralf; Han, Dong; Hemmig, Rene; Jiang, Tao; Knoepfel, Thomas; Maginnis, Jillian; Mutnick, Daniel; Pei, Wei; Ruzzante, Giulia; Syka, Peter; Zhang, Guobao; Zhang, Yi; Zink, Florence; Zipfel, Géraldine; Hawtin, Stuart; Junt, Tobias; Michellys, Pierre-Yves

Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist

基于结构的TLR8结合筛选先导化合物结构优化,得到体内有效的TLR7/8拮抗剂

Betschart, Claudia; Faller, Michael; Zink, Florence; Hemmig, René; Blank, Jutta; Vangrevelinghe, Eric; Bourrel, Marjorie; Glatthar, Ralf; Behnke, Dirk; Barker, Kerstin; Heizmann, Andreas; Angst, Daniela; Nimsgern, Pierre; Jacquier, Sébastien; Junt, Tobias; Zipfel, Géraldine; Ruzzante, Giulia; Loetscher, Pius; Limonta, Sarah; Hawtin, Stuart; Andre, Cedric Bernard; Boulay, Thomas; Feifel, Roland; Knoepfel, Thomas